Assuntos
Poluição Ambiental/efeitos adversos , Doenças Genéticas Inatas/etiologia , Poluentes do Solo/efeitos adversos , Poluentes da Água/efeitos adversos , DNA/genética , Poluição Ambiental/análise , Doenças Genéticas Inatas/diagnóstico , Humanos , Cazaquistão , Mutação , Poluentes do Solo/análise , População Urbana , Poluentes da Água/análiseRESUMO
A study of the functional state of the sympathico-adrenal system by determining the diurnal urine excretion of catecholamines and DOPA was conducted in 29 patients with meningoencephalitis of a meningococcal etiology. These studies demonstrated a significant activation of its adrenal link and a tendency to an increase of activity in the sympathical link with a drop of the reserve possibilities. These changes were most distinctly expressed in cases with prevalent localization of the pathological process in the deep brain structures. These facts made it possible to conclude that there is a lesion in the link of a control of the sympathico-adrenal system. These data were confirmed by results of a study in 18 patients with meningococcal infections by physiological loadings with insulin and adrenalin and a study of the catecholamines and DOPA in the urine portions, which exert specific influence on the state of activity of the sympathico-adrenal system through the hypothalamus and reticular formation.
Assuntos
Glândulas Suprarrenais/fisiopatologia , Catecolaminas/urina , Di-Hidroxifenilalanina/urina , Infecções Meningocócicas/fisiopatologia , Sepse/fisiopatologia , Sistema Nervoso Simpático/fisiopatologia , Adolescente , Adulto , Dopamina/urina , Epinefrina/urina , Feminino , Humanos , Insulina , Masculino , Meningite Meningocócica/fisiopatologia , Meningite Meningocócica/urina , Infecções Meningocócicas/urina , Pessoa de Meia-Idade , Norepinefrina/urina , Sepse/urinaAssuntos
Medula Suprarrenal/patologia , Infecções Meningocócicas/patologia , Adolescente , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
Content of adrenaline and DOPA was distinctly decreased in adrenal glands of 32 persons who died of meningitis, as compared with 7 persons, death of which was caused by trauma. The lowest content of catecholamines was found in cases of development of meningoencephalitis and also after massive hemorrhages into the adrenal glands. The alterations observed were due to impairment of the synthesis, secretion and probably, storage of biogenic amines in the adrenal medulla.