[Orthodontic treatment of adult patients with mandibular retrognathia]. / Ortodonticheskoe lechenie vzroslykh patsientov s nizhnei retrognatiei.

This article describes a case report of the patient with mandibular retrognathia, class II malocclusion, constriction and deformation of dental arches and bimaxillary protrusion. Due to the patient's refuse to undergo the orthognathic surgery, after diagnostic, it was decided to carry out the orthodontic dentoalveolar compensation. The combined use of the functional fixed telescopic appliance (FFTA), bracket system and orthodontic miniscrews made it possible to effectively normalize the mandibular position, achieve orthognathic occlusion, eliminate bimaxillary protrusion and improve the face profile. This method significantly reduced invasiveness and time of orthodontic treatment.

[Objective and subjective assessment of the quality and effectiveness of orthodontic treatment]. / Ob"ektivnaya i sub"ektivnaya otsenka kachestva i effektivnosti ortodonticheskogo lecheniya.

Dentofacial anomalies occupy one of the leading places among dental diseases in people of different age groups. Analysis of epidemiological data on the prevalence of dentoalveolar anomalies indicates that there is no tendency to decrease it in Russia and abroad countries. The demand for orthodontic treatment is increasing with the development of new technologies and materials, the development of modern methods of treatment in the field of dentistry. This trend is accompanied by increased requirements for the quality of orthodontic care. The patient's dissatisfaction with the result of treatment most often arises because of a discrepancy between his subjective assessment of treatment and the objective anatomical, functional and aesthetic state of occlusion. The use of methods for quantitative assessment of dentoalveolar anomalies and the quality of orthodontic treatment makes it possible to objectively substantiate the choice of tactics of orthodontic care and increase its effectiveness. At the same time, the patient's subjective assessment of the quality of orthodontic treatment allows one to see how the proposed (implemented) treatment plan reflects the patient's main complaints and to assess the degree of his satisfaction with the achieved result. That`s why, the issue of using methods of objective and subjective assessment of the quality and effectiveness of orthodontic treatment is relevant today. The purpose of the literature review is to consider the development and implementation of criteria for an objective and subjective assessment of the outcome of orthodontic treatment.

[Assessment of dental arches expansion using ligature and passive self-ligating braces in combination with Pitts broad arches and early elastics]. / Otsenka rasshireniya zuboal'veolyarnykh dug u patsientov pri ispol'zovanii ligaturnykh i passivnykh samoligiruyushchikh breket-sistem v sochetanii s dugami Pittsa shirokoi formy i rannei elastichnoi tyagi.

THE AIM OF THE STUDY: Was to analyze the effectiveness of the use of Pitts Broad and early elastics in the treatment of patients with narrowing and deformation in dentition. MATERIALS AND METHODS: The results of orthodontic treatment of 46 adult patients with narrowing and deformation in dentition are presented. Patients were separated in 2 groups, depending on the algorithm of treatment: group 1 - using the braces of passive self-ligation, Pitts Broad and early short elastics; group 2 - using ligature braces and archwires Orthos. RESULTS: Biometric analysis of the diagnostic models of the 1st group after treatment showed a significant increase in the area of the premolars on the upper (between premolars - 39.8±0.4 mm, between molars - 48.3±0.5 mm) and lower (between premolars - 37.1±0.5 mm, between molars - 46.3±0.6 mm) jaws compared to the data before treatment. Biometric analysis of the diagnostic models of the 2d group showed that expansion in the area of the molars was achieved in a much smaller volume in the upper and lower jaws, compared with the 1st group (upper jaw: between premolars - 35.7±0.4 mm, between molars - 43.5±0.5 mm; lower jaw: between premolars - 33.2±0.3 mm, between molars - 42.3±0.5 mm). CONCLUSION: The passive self-ligation system in combination with protocol of Pitts Broad already contributes the expansion of dentition in aesthetically significant areas (distal regions) in the early stages of treatment. Using of early light elastics provides an early control of the lateral tooth torque, which allows achieving a harmonious and wide smile at the end of treatment.

[The experimental study of a Russian orthodontic mini-screw]. / Eksperimental'noe issledovanie otechestvennogo ortodonticheskogo minivinta.

BACKGROUND: The aim of this research is the experimental study measuring stability of the orthodontic miniscrews «Turbo¼ designed in Russia in comparison with its foreign analogues, namely, «Vector Tas¼ (USA) and «BioRay¼ (Taiwan). MATERIAL AND METHODS: Four self-drilling orthodontic miniscrews of each manufacturer, i.e. «Vector Tas¼, USA, (10-mm length, 2-mm diameter), «BioRay¼, Taiwan, (10-mm length, 2-mm diameter), «Turbo¼, Russia, (9-mm length, 2-mm diameter), a total of 12 items, were inserted into native pig mandible sample. Their stability was estimated by torques using a dynamometer (Zahoransky AG, Germany) and «Periotest¼ device («Periotest M¼, Germany). This experiment was conducted in native pig mandible sample immediately after the screws' placement and in 7 days after loading at an angle 70°. RESULTS: After application of a load, the decreased torque values and increased Periotest values were registered in all orthodontic miniscrews. CONCLUSION: Orthodontic miniscrews «Turbo¼ designed in Russia are slightly inferior to «VectorTas¼ miniscrews and superior to «BioRay¼ miniscrews in primary stability and stability after 7 days under loading.

[Algorithm for treatment of patients with class II malocclusion rejecting orthognathic surgery]. / Algoritm lecheniya patsientov s nizhnei retrognatiei, otkazavshikhsya ot kostno-rekonstruktivnoi operatsii.

The aim of this study is to develop algorithms for the treatment of patients with class II malocclusion and incisor protrusion using the combination of bracket system, functional fixed telescopic appliance (FFTA) and skeletal anchorage, which allows to achieve effective dentoalveolar compensation of skeletal forms of class II malocclusion. MATERIALS AND METHODS: Orthodontic treatment of 60 patients with class II malocclusion at the age of 18 to 44 years, using the bracket system, FFTA and orthodontic miniscrews was performed. In order to assess the results of treatment, cone-beam computed tomography were obtained at the beginning and at the end of treatment. RESULTS: As a result of the treatment normalization of lower jaw position, dental position and occlusion were achieved, the lower incisors protrusion was eliminated and the facial profile was improved, reliably confirmed by lateral cephalograms. CONCLUSION: The proposed treatment algorithm proved to be effective for stable correction of skeletal class II malocclusion in patients rejecting orthognathic surgery.

[The role of fast and slow potassium currents in electrical activity of amphibian myelinated nerve fibres].

The paper reviews the information about the role of fast and slow potassium currents in electrical activity of amphibian myelinated nerve fibres. It demonstrates the importance of discovering of fast and slow potassium currents and their following pharmacological separation (by potassium channels blockers 4-aminopyridine and tetraethylammonium) in investigation of mechanisms of biological potentials generation. The information about the existence of fast and slow potassium channels in the nerve membrane and about the properties of 4-aminopyridine and tetraethylammonium action served as a base for determination the nature of biological potentials and discovering the mechanism of potential-dependent action of 4-aminopyridine that for tens of years suffered from the lack of adequate explanation.

[Prolonged after-potentials of the myelinated nervous fibres in amphibia after 4-aminopyridine-induced blockage of potassium channels].

Myelinated nerve fibres of Rana ridibunda Pallas were studied by using extra-cellular recording technique. 4-aminopyridine, a blocker of fast potassium channels produced considerable changes in duration of the after-depolarization and increase in total membrane depolarization (evaluated by an action potential area). These effects were time-dependent. The after-depolarization duration under 4-aminopyridine (4-AP) treatment changes in 3 phases: at the beginning of the exposure its duration increased; then the increase stopped; and later duration of the after-depolarization start to decrease. The last phase was often followed by hyperpolarizing after-potential. The interchange of these phases accompanies by statistically significant increase of the action potential area (from 189.201 +/- 28.437 m x ms in normal solution to 489.945 +/- 41.75 m x ms in 5 minutes after 4-AP application). These observations are explained as a result of the increased activation of the slow potassium channels and decreased portion of fast potassium channels involved in membrane repolarization. The decrease in post-tetanic depolarization duration, the appearance of the post-tetanic hyperpolarization at low frequencies and increase of post-tetanic hyperpolarization at higher frequencies of stimulation under 4-AP treatment are dependent on activation of slow potassium channels.

[Transformation of electrical activity in the myelinated nerve fibres of amphibia by 4-aminopyridine].

Using the extracellular recording we studied the effect of 4-aminopyridine (4-AP), a potassium channel blocker on the electrical activity of the myelinated nerve fibres of amphibia Rana ridibunda Pallas. Two main types of the reaction on 4-AP were established: extension of the action potential and multi-spike response. In some cases the nerve fibres with multi-spike response generated spontaneous activity without stimulation in the form of bursts of action potentials. During repetitive stimulation 4-AP decreased after-depolarization (at the beginning of the stimulation), the posttetanic after-depolarization and the development of posttetanic after-hyperpolarization. Using the paired stimulation it was established that the spike and after-depolarization of the second action potential depended on the size of after-depolarization after the first action potential. The effects of 4-AP were strongly time-dependent.

[Study of the action of immunomodulator T-activin on electric properties of plasma membranes of thymus cells by the use of fluorescent probes]. / Izuchenie deistviia immunomoduliatora T-aktivina na élektricheskie svoistva plasmaticheskoi membrany kletok timusa s pomoshch'iu fliuorestsentnykh zondov.

T-activin alters the electric properties of plasmatic membranes of the T-activin treated suspension of mouse (CBAX X057B1) F1 thymic cells. These alterations were registered by means of negative charged fluorescent probe l-anilino-naphthalene-8-sulfonate (ANS) and positive charged 4-(p-dimethylaminostyryl)-1-methylpyridinium (DSM) by measurement of their fluorescence in the individual thymic cell. Apparently, T-activin leads to depolarization of transmembrane potential on plasmatic membrane of thymic cells. It seems that action of T-activin is similar to the effect of polycations, which alter cells ionic streams during lymphocyte activation. However, there is a version, that T-activin acts like neuraminidase, but it is activity less expressed.