RESUMO
We studied the functional role of individual subtypes of muscarinic cholinoceptors in the pathogenesis of neuroleptic parkinsonism in rats. Blockade of M4 receptors prevented the development of extrapyramidal disorders, which was abolished by simultaneous blockade of M2 receptors. The data suggest that various subtypes of muscarinic receptors are involved in the regulation of dopamine concentration.
Assuntos
Catalepsia/etiologia , Receptor Muscarínico M2/antagonistas & inibidores , Receptor Muscarínico M2/fisiologia , Animais , Catalepsia/induzido quimicamente , Ciclopentanos/farmacologia , Diaminas/farmacologia , Dopamina/metabolismo , Haloperidol , Masculino , Ácidos Mandélicos/farmacologia , Antagonistas Muscarínicos/farmacologia , Piperidinas/farmacologia , Síndrome , Triexifenidil/farmacologiaRESUMO
Mathematical analysis of the data obtained in experiments on the whole organism revealed that blockade of M(2)-cholinergic receptors increased both heart and respiratory rates. Blockade of M(1)-cholinergic receptors alleviated tachycardia induced by M(2)-receptor blockade.
Assuntos
Coração/fisiologia , Receptores Muscarínicos/metabolismo , Respiração , Animais , Frequência Cardíaca , Ligantes , Modelos Lineares , Modelos Teóricos , Ratos , Receptor Muscarínico M1 , Receptor Muscarínico M2 , Receptores Colinérgicos/metabolismo , Tórax/fisiologiaRESUMO
The toxicological study was performed in order to establish the optimum carbon thromboresistant coat of titanium in creating new constructions of the artificial heart valves under conditions of chronic experiments in albino rats. Fine samples of carbon coats made by different techniques were studied. The biological activity of only one coat made by the method of ionoplasmic spraying with using chemically pure carbon target was established.
