RESUMO
Hepatocellular carcinoma is generally associated with long-standing chronic liver disease of diverse etiology, most commonly HBsAg-positive chronic active hepatitis, hemochromatosis, or alcoholic liver disease. Patients with primary biliary cirrhosis have only rarely developed a subsequent hepatocellular carcinoma. We report such a patient, a 77-year-old woman with an early, precirrhotic stage of primary biliary cirrhosis who developed a hepatoma.
Assuntos
Carcinoma Hepatocelular/etiologia , Cirrose Hepática Biliar/complicações , Neoplasias Hepáticas/etiologia , Idoso , Carcinoma Hepatocelular/patologia , Feminino , Humanos , Cirrose Hepática Biliar/patologia , Neoplasias Hepáticas/patologiaRESUMO
Severe intoxication from excessive acetaminophen without suicidal intent occurred in three patients, all alcohol abusers, one with evidence of underlying cirrhosis. Apparently, acetaminophen toxicity may be enhanced by alcohol.
Assuntos
Acetaminofen/intoxicação , Alcoolismo/complicações , Doença Hepática Induzida por Substâncias e Drogas/etiologia , Acetaminofen/administração & dosagem , Acetaminofen/farmacologia , Adulto , Doença Hepática Induzida por Substâncias e Drogas/patologia , Interações Medicamentosas , Etanol/farmacologia , Humanos , Fígado/patologia , Cirrose Hepática Alcoólica/complicações , Masculino , Pancreatite/complicações , Transtornos Relacionados ao Uso de SubstânciasRESUMO
A 40-year-old woman with ulcerative colitis and sclerosing cholangitis developed jaundice unresponsive to steroids. Endoscopic retrograde cholangiopancreatography showed multiple cystic dilatations similar in appearance to a previous report of a patient with sclerosing cholangitis who had an associated cholangiocarcinoma. Subsequent laparotomy led to the diagnosis of a cholangiocarcinoma. We conclude that the presence of cystic dilatation on cholangiography in patients with sclerosing cholangitis is highly suggestive of an associated cholangiocarcinoma.
