[Experimental study of late effects of the damaging action of doxorubicin on the lymphoid tissue]. / Otdalennye éffekty povrezhdaiushchego deistviia doksorubitsina na limfoidnuiu tka'n v éksperimente.

It was shown in experiments with CBA/Lac J mice that both a single use of doxorubicin (MID) and its use during a treatment course (1/10 LD50.10) induced impairment of the morphological composition of the central and peripheral lymphoid organs along with changes in the functional activity of separate cell populations of the immune system which persisted over a prolonged period up to 3 months. The course use of the drug resulted in a significant decrease in the proliferative response of the splenocytes to the polyclonal T- and B-cell mitogens in 1 month, which was followed by inhibition of interleukin-2 production. On the contrary, 1 month later, the single administration of the cytostatic induced activation of the LPS-responding cell populations and an increase in production of the growth factor in the culture of T-lymphocytes.

[The role of endogenous enkephalins in the regulation of bone marrow hematopoiesis in stress]. / Ob uchastii éndogennykh énkefalinov v reguliatsii kostno- mozgovogo krovetvoreniia pri stresse.

A study was made of the effect of the enkephalinase inhibitor D-phenylalanine on hematopoiesis during the immobilization stress. The long-term treatment with D-phenylalanine before the immobilization stress resulted in a significant increase of plasma ley-enkephalin in mice during the first day after exposure. Later the inhibition of bone marrow hyperplasia was recorded. There were no changes in hematopoiesis provided D-phenylalanine was injected after the immobilization. It is suggested that endogenous enkephalins may take part in the regulation of hematopoiesis at the early period of the stress reaction formation.