RESUMO
A 61-year-old man was treated with imiquimod 5% cream for superficial basal cell carcinoma, five times per week for 13 weeks. This resulted in vitiligo-like depigmentation and poliosis in the area of treatment. This rare side-effect has been noted in previous case reports of imiquimod treatment for both genital warts and superficial basal cell carcinoma. This highlights the importance of such a side-effect being discussed with the patient who is to be treated with imiquimod, particularly in cosmetically sensitive areas.
Assuntos
Aminoquinolinas/efeitos adversos , Antineoplásicos/efeitos adversos , Carcinoma Basocelular/tratamento farmacológico , Neoplasias Cutâneas/tratamento farmacológico , Vitiligo/induzido quimicamente , Administração Tópica , Aminoquinolinas/uso terapêutico , Antineoplásicos/uso terapêutico , Biópsia por Agulha , Carcinoma Basocelular/patologia , Seguimentos , Humanos , Hipopigmentação/induzido quimicamente , Hipopigmentação/patologia , Imiquimode , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Medição de Risco , Neoplasias Cutâneas/patologia , Vitiligo/patologiaRESUMO
A 10-year-old girl with cutaneous, oral and gastrointestinal vascular lesions was referred for consideration of laser treatment of her skin lesions. She was noted to have multiple venous malformations predominantly affecting the hands and feet, some of which had been present from birth. Her right hand was deformed by multiple venous malformations, and X-rays of this hand revealed enchondromata within metacarpal and phalangeal bones. She was known to have extensive involvement of her gastrointestinal tract by venous malformations, resulting in refractory iron-deficiency anaemia. In view of the multiple cutaneous and gastrointestinal vascular lesions, a diagnosis of blue rubber bleb naevus syndrome had been made many years earlier. However, after recognition of the characteristic enchondromata, this diagnosis has been revised to Maffucci's syndrome. In addition to her ongoing dermatological and paediatric follow up, she has now been referred to the orthopaedic surgeons for surveillance of her skeletal lesions.
Assuntos
Encondromatose/diagnóstico , Hemorragia Gastrointestinal/diagnóstico , Deformidades Congênitas da Mão/diagnóstico , Anemia Ferropriva/etiologia , Criança , Diagnóstico Diferencial , Encondromatose/complicações , Encondromatose/congênito , Encondromatose/patologia , Feminino , Pé/patologia , Hemorragia Gastrointestinal/complicações , Hemorragia Gastrointestinal/congênito , Hemorragia Gastrointestinal/patologia , Mãos/patologia , Deformidades Congênitas da Mão/complicações , Deformidades Congênitas da Mão/patologia , HumanosRESUMO
A 27-year-old man, immunosuppressed from recent chemotherapy for metastatic Ewing's sarcoma, presented with a 1-week history of a painful, pruritic, papulovesicular eruption on the hands and feet. A diagnosis of hand, foot and mouth disease was made based on histology, detection of Enterovirus ribonucleic acid by polymerase chain reaction on a swab from a vesicle, and a four-fold increase in Enterovirus antibody levels. At no stage however, were there lesions in the mouth. Another unusual feature in this case was a prolonged course, presumably as a result of immunosuppression. After 3 1/2 weeks he was commenced on oral aciclovir 200 mg five times daily, with subsequent resolution of all lesions within 5 days. There may be a role for systemic aciclovir in some patients with hand, foot and mouth disease.
Assuntos
Infecções por Enterovirus/diagnóstico , Doença de Mão, Pé e Boca/diagnóstico , Hospedeiro Imunocomprometido , Aciclovir/uso terapêutico , Adulto , Antivirais/uso terapêutico , Diagnóstico Diferencial , Enterovirus/isolamento & purificação , Infecções por Enterovirus/complicações , Infecções por Enterovirus/tratamento farmacológico , Doença de Mão, Pé e Boca/complicações , Doença de Mão, Pé e Boca/tratamento farmacológico , Humanos , Masculino , Sarcoma de Ewing/complicações , Sarcoma de Ewing/terapia , Resultado do TratamentoRESUMO
We present three members of a Queensland family with clinical and histopathological features consistent with Birt-Hogg-Dubé syndrome. Two of the three family members were able to be screened for associated disorders. The mother of the family was found to have a solitary colonic polyp, a large ovarian cyst and two chorioretinal scars. No associated disorders were found on investigation of one of the two affected sons.
