The effect of a single intravitreal implantation of dexamethasone on the fellow eye in bilateral non-infectious uveitis - case report.

OBJECTIVE: To present the influence of dexamethasone intravitreal implant due to macular edema in non-infectious uveitis in the fellow eye. PATIENTS AND METHODS: A 25-year-old patient with a long history of juvenile arthritis with concomitant recurrent bilateral uveitis, complicated with increases of intraocular pressure and macular edema was treated with a single intravitreal dexamethasone implant into the eye with lower visual acuity. RESULTS: During a 36-month follow-up, the patient's bilateral visual acuity improved. The retinal thickness in both maculae decreased. CONCLUSIONS: Treating macular edema in the course of recurrent uveitis accompanying a systemic disease with dexamethasone depot in vitreous may play a beneficial role also in the fellow eye, when affected. This therapeutic effect in the fellow eye may suggest that the medication can penetrate into the circulatory system and reach such other organs as the fellow eye.

Vitreous amyloidosis in two sisters as the indication of transthyretin-related familial form of systemic amyloidosis among liver transplantation candidates.

Vitreous amyloidosis, a rare condition characteristic of the familial form of systemic amyloidosis with polyneuropathy, is caused by a mutation in the transthyretin (TTR) gene. Herein we have presented 2 sisters with involvement of the vitreous body, which prompted a subsequent diagnosis of the TTR-related, familial form of systemic amyloidosis. Due to the progressive character of the disease and poor prognosis, the patients have been considered for liver transplantation, which at present is the only treatment option for this disease.

Pemphigoid-like ocular lesions in patients with graft-versus-host disease following allogeneic bone marrow transplantation.

We present two patients who developed keratitis sicca and pemphigoid-like symptoms following allogeneic bone marrow transplantation (BMT). The diagnosis of ocular graft-versus-host disease (GvHD) was considerably delayed in both. They were admitted to the reference ophthalmology and posttransplant care departments years after allogeneic BMT, when skin biopsy revealed changes typical for chronic GvHD. In both cases either systemic or local immunosuppressive treatment led to improvement of the clinical condition but did not significantly change patients' quality of life.

[Ocular manifestations in sarcoidosis]. / Objawy oczne w przebiegu sarkoidozy.

PURPOSE: The ophthalmic examination of patients with diagnosed systemic sarcoidosis. MATERIAL AND METHODS: 33 patients (17 women, 16 men), aged 22-60 years had ophthalmic examination (visual acuity, anterior and posterior segment evaluation, applanation tonometry). In 8 patients repeated examination was performed (duration of observation: 2-31 months). RESULTS: In 27 patients no characteristic features of ocular sarcoidosis were found. In 6 persons (18.2%) variety of ocular lesions was recognized (nodular infiltrations of the eyelids, chronic uveal inflammation, signs of anterior and posterior uveitis in the past, optic disc oedema). In 3 cases ocular lesions preceded the signs of systemic sarcoidosis. This emphasizes the importance of the routine ophthalmic examination of patients with suspected or proven sarcoidosis.

[The intermediate uveitis with systemic symptoms: a case report]. / Zapalenie czesci posredniej blony naczyniowej ze wspólistniejacymi objawami ogólnymi.

The case of 26-year old male patient with typical clinical intermediate uveitis (vitritis, periphlebitis) with accompanying leucopenia, bradycardia and demyelination focal areas in brain of unknown etiology is presented. The asymptomatic periphlebitis was also found in the eyes of his twin brothers (30 years old) and sister (20 years old).

[Late ophthalmoscopic changes in patients after malignant hypertension]. / Odlegle zmiany na dnie oczu u chorych po przebytym nadcisnieniu zlosliwym.

AIM: Comparison of eye fundus changes in patients in whom malignant hypertension was diagnosed. MATERIAL AND METHODS: 14 patients (6 F, 8 M) aged 24-54 years were examined. In all cases kidney disease was the cause of arterial hypertension. 11 patients underwent kidney transplantation (0.5-20 years before the study), 2 patients was hemodialysed, 1 received only pharmacological treatment. RESULTS: During the first examination in two patients IV grade of hypertensive retinopathy (K-W classification) was found, in the rest of the patients I/II or II grade with typical changes for malignant hypertension in the past (Elschnig's spots) was found. In control examinations (6 months-21 years) the persistence of the previously noticed changes was observed.