[Relationship between surgical volumes and 30-day mortality in patients with oesophagus and stomach cancer: a review of the literature and metanalysis]. / La relazione fra volumi e mortalità a 30 giorni nella chirurgia oncologica di esofago e stomaco: revisione della letteratura e metanalisi.

OBJECTIVES: to analyse the relationship between annual hospital volumes of surgery for oesophageal and gastric cancer and 30-day mortality. DESIGN: a systematic review of the literature has been carried out on these topics by searching Medline for the years 1998-2012 and using two ad hoc search strings. For oesophageal cancer, the most recent and best quality systematic review was updated by including further studies, and then a metanalysis was carried out. For gastric cancer, two different metanalyses on low and high volumes were performed. RESULTS: regarding oesophageal carcinoma, the study confirmed the association between 30-day mortality and the number of annual hospital interventions for this pathology. As for stomach cancer, the two metanalyses confirmed the role of high-volume surgery in reducing the outcome considered. CONCLUSIONS: this study confirms the association between short-term outcomes and the number of annual hospital interventions for oesophageal and gastric cancer. The results obtained may be important for health care policy makers and administrators/managers in order to improve quality of care for patients with oesophageal or stomach cancer.

Identification of risk conditions for the development of adrenal disorders: how optimized PubMed search strategies makes the difference.

The exponential growth of scientific literature available through electronic databases (namely PubMed) has increased the chance of finding interesting articles. At the same time, search has become more complicated, time consuming, and at risk of missing important information. Therefore, optimized strategies have to be adopted to maximize searching impact. The aim of this study was to formulate efficient strings to search PubMed for etiologic associations between adrenal disorders (ADs) and other conditions. A comprehensive list of terms identifying endogenous conditions primarily affecting adrenals was compiled. An ad hoc analysis was performed to find the best way to express each term in order to find the highest number of potentially pertinent articles in PubMed. A predefined number of retrieved abstracts were read to assess their association with ADs' etiology. A more sensitive (providing the largest literature coverage) and a more specific (including only those terms retrieving >40 % of potentially pertinent articles) string were formulated. Various researches were performed to assess strings' ability to identify articles of interest in comparison with non-optimized literature searches. We formulated optimized, ready applicable tools for the identification of the literature assessing etiologic associations in the field of ADs using PubMed, and demonstrated the advantages deriving from their application. Detailed description of the methodological process is also provided, so that this work can easily be translated to other fields of practice.