RESUMO
Proton pump inhibitors (PPIs) have been known to cause bradycardia. We evaluated the effect of three PPIs, i.e. omeprazole, rabeprazole and pantoprazole on the heart rate of frog. The in situ frog heart preparation was set up. Heart rate and amplitude of contraction were studied following administration of different doses of the three PPIs. Statistical analysis was done by using Graphpad statistical software system. After 1 mg of omeprazole and rabeprazole, and 2 mg pantoprazole, the heart rate was similar as compared to baseline (p >0.05). After 2 mg of omeprazole and rabeprazole, and 4 mg pantoprazole, the reduction in heart rate was significant (p <0.05). In addition, pantoprazole caused negative ionotropic effect. The three PPIs showed a dose-dependent negative chronotropic effect in the frog heart prepration.
Assuntos
Frequência Cardíaca/efeitos dos fármacos , Coração/efeitos dos fármacos , Inibidores da Bomba de Prótons/farmacologia , 2-Piridinilmetilsulfinilbenzimidazóis/farmacologia , Animais , Anuros , Relação Dose-Resposta a Droga , Omeprazol/farmacologia , Pantoprazol , RabeprazolRESUMO
Spinal cord compression due to extramedullary hematopoiesis (EMH) is a rare complication of thalassemia and generally presents as paraparesis with sensory impairment. Complete paraplegia is extremely rare in EMH due to thalassemia although it is known to occur in polycythemia vera and sickle cell anemia. Treatment options mostly include surgery and/or radiotherapy. Whereas cases presenting with paraparesis have been treated with either surgery or radiotherapy with equal frequency and efficacy, almost all reported cases with paraplegia have been treated with surgery with or without radiation therapy. We hereby report a case of thalassemia intermedia with paraplegia treated successfully with radiotherapy.
Assuntos
Radioisótopos de Cobalto/uso terapêutico , Hematopoese Extramedular , Paraplegia/etiologia , Teleterapia por Radioisótopo , Compressão da Medula Espinal/radioterapia , Talassemia beta/complicações , Adulto , Transfusão de Sangue , Cálcio/uso terapêutico , Contraindicações , Descompressão Cirúrgica , Difosfonatos/uso terapêutico , Espaço Epidural , Ácido Fólico/uso terapêutico , Fraturas Espontâneas/etiologia , Humanos , Imidazóis/uso terapêutico , Masculino , Osteoporose/complicações , Osteoporose/tratamento farmacológico , Compressão da Medula Espinal/complicações , Ácido Zoledrônico , Talassemia beta/fisiopatologia , Talassemia beta/terapiaRESUMO
Fibrous dysplasia of the spine is uncommon, especially in monostotic form. Isolated vertebral involvement in polyostotic form is very rare. We report a case of polyostotic fibrous dysplasia with lesions localized to dorso-lumbar spine in a 45-year-old rheumatoid arthritis patient. No associated appendicular lesions, cutaneous manifestations or endocrinopathies were seen. The extreme rarity of this type of lesion can pose a diagnostic dilemma, and biopsy is required for diagnosis. The association with rheumatoid arthritis in our case seems to be a chance occurrence.
Assuntos
Displasia Fibrosa Óssea/diagnóstico , Doenças da Coluna Vertebral/diagnóstico , Artrite Reumatoide/complicações , Diagnóstico Diferencial , Difosfonatos/uso terapêutico , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Doenças da Coluna Vertebral/tratamento farmacológico , Tomografia Computadorizada de EmissãoRESUMO
Hydatid disease is a parasitic infection that most commonly involves the liver. Imaging plays a vital role in the diagnosis of this disease. Rupture of the cyst can give rise to a wide spectrum of complications. We describe a case of hepatic hydatid cyst with rupture into the biliary tree, right pleural cavity and dissemination into the peritoneal cavity, with associated splenic hydatid cysts. MRI may be a useful non-invasive diagnostic tool in such disseminated cases to define the complete extent of the disease.
