1.
Study of the complexation of oxacillin in 1-(4-carbomethoxypyrrolidone)-terminated PAMAM dendrimers.
J Phys Chem B
; 117(47): 14865-74, 2013 Nov 27.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24219418
RESUMO
The complexation of oxacillin to three generations of 1-(4-carbomethoxypyrrolidone)-terminated PAMAM dendrimers was studied with NMR in CD3OD and CDCl3. The stochiometries, which were determined from Job plots, were found to be both solvent- and generation-dependent. The dissociation constants (K(d)) and Gibbs energies for complexation of oxacillin into the 1-(4-carbomethoxypyrrolidone)-terminated PAMAM dendrimer hosts were determined by (1)H NMR titrations and showed weaker binding of oxacillin upon increasing the size (generation) of the dendrimer.