RESUMO
Pericarditis due to interferon alpha therapy during treatment for chronic hepatitis C. We report a patient with pericarditis during therapy with interferon alpha 2b for chronic hepatitis C viral infection. We review interferon alpha therapy and hepatitis C virus side-effects on the cardiovascular system.
Assuntos
Antivirais/efeitos adversos , Hepatite C Crônica/tratamento farmacológico , Interferon-alfa/efeitos adversos , Pericardite/induzido quimicamente , Adulto , Antivirais/uso terapêutico , Feminino , Humanos , Interferon alfa-2 , Interferon-alfa/uso terapêutico , Proteínas RecombinantesRESUMO
A patient with cystic dystrophy in heterotopic pancreatic tissue, localized in the second duodenum, is described. Diagnosis was assessed by computed tomography, endosonography and magnetic nuclear resonance (MNR). Medical treatment with octreotid during three weeks was effective but duodenal stenosis persisted. Finally, pylorus preserving pancreaticoduodenectomy was performed. Microscopy examination confirmed the diagnosis and the efficiency of medical treatment. A review of the literature about cystic dystrophy is done.
Assuntos
Coristoma/terapia , Duodenopatias/terapia , Pâncreas/patologia , Antineoplásicos Hormonais/uso terapêutico , Coristoma/patologia , Duodenopatias/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Octreotida/uso terapêutico , PancreaticoduodenectomiaAssuntos
Neoplasias do Sistema Biliar/complicações , Ductos Pancreáticos/cirurgia , Neoplasias Pancreáticas/complicações , Papiloma/complicações , Neoplasias do Sistema Biliar/cirurgia , Colecistectomia , Evolução Fatal , Humanos , Masculino , Pessoa de Meia-Idade , Ductos Pancreáticos/patologia , Neoplasias Pancreáticas/patologia , Neoplasias Pancreáticas/cirurgia , Pancreaticoduodenectomia , Papiloma/patologia , Papiloma/cirurgiaRESUMO
Hemoblot, a new immunological faecal occult blood test, produced by Gamma, Angleur, Belgium, was characterized and compared with another immunological test (HemeSelect, SmithKline Diagnostics, USA) and with a guaiac test (Hemoccult II, SmithKline Diagnostics). The analytical sensitivity of Hemoblot is 0.15 mg haemoglobin/g faeces and the test is specific for human haemoglobin. In addition, 135 symptomatic patients who had to undergo a colonoscopy were tested using the three tests. Two criteria were considered for the analysis: (1) the blood criterion: any pathology likely to cause colorectal or other bleeding; and (2) the precancerous-cancerous criterion: the pathology being either a colorectal polyp > 0.5 cm or a colorectal cancer. Considering both criteria, the sensitivity of Hemoblot was significantly higher than the sensitivity of Hemoccult: 38% and 23%, respectively, for the blood criterion; and 54% and 29% for the precancerous-cancerous criterion. Sensitivity and specificity did not differ statistically between Hemoblot and HemeSelect but Hemoblot was faster and simpler to perform. It could be widely used in mass screening.
Assuntos
Neoplasias do Colo/diagnóstico , Sangue Oculto , Neoplasias Retais/diagnóstico , Adulto , Idoso , Idoso de 80 Anos ou mais , Anticorpos Monoclonais , Pólipos do Colo/diagnóstico , Colonoscopia , Ensaio de Imunoadsorção Enzimática , Hemorragia Gastrointestinal/diagnóstico , Guaiaco , Hemoglobinas/análise , Humanos , Técnicas Imunoenzimáticas , Pólipos Intestinais/diagnóstico , Programas de Rastreamento , Pessoa de Meia-Idade , Lesões Pré-Cancerosas/diagnóstico , Valor Preditivo dos Testes , Kit de Reagentes para Diagnóstico , Reprodutibilidade dos Testes , Sensibilidade e EspecificidadeRESUMO
The authors report the case of a 40-year-old woman with fever and diarrhoea in whom a tumour of the small intestine was discovered by computerized tomography (CT), the barium meal being not contributory. Transcutaneous fine needle aspiration biopsies under CT guiding revealed a grade II leiomyosarcoma. Twenty months after radical resection, the patient is alive and asymptomatic. The authors review the literature about the histological grading and the immunocytochemical characteristics of leiomyosarcoma, its treatment and prognosis.
