[Chymase in the system proteinase-proteinase inhibitor in pathogenesis of hypertension]. / Khimaza v sisteme proteinaza-ingibitor proteinaz v patogeneze gipertonicheskoi bolezni.

Investigated in the study was activity of proteinases, nontripsin-like proteinases (NTLP), a1-inhibitor of proteinases (a1-PI), and a2-macroglobulin (a2-MG) in the blood serum of workers of the Kharkov tile plant and those of the Institute of Therapy of the AMS of Ukraine, who had been exposed to stress factors, and during the early stages of hypertensive disease (HD). The activity of proteinases, NTLP appeared to be decreased in the group of HD patients. In both groups there was a decrease in the level of a1-PI and a rise of the activity of chimase, a2-MG. The authors have come to the conclusion about prevailing of nervous, immunological stimuli in the above examinees, specificity of the part chimase has in formation and progression of HD, and important role that a2-MG plays in the activity of chimase.

[Effect of enape combined with nebilet in hypertension]. / Effektivnost' primeneniia énapa v sochetanii s nebiletom pri gipertonicheskoi bolezni.

Patients with stage II hypertensive disease have been shown to derive apparent benefit from treatment with a combination of the beta-adrenoblocker nebivolol and inhibitor of the angiotensin-converting enzyme enap that was evidenced by improvement in hemodynamics, in echocardiographic characteristics promoting a decline in the activity of the basic enzyme of the tissue formation angiotensin II chimase and an increase in the level of its most important inhibitor alpha-2-macroglobulin.