[Effect of a factor (factors) secreted by human amnion cells on the proliferative activity of normal and transformed fibroblasts]. / Vliianie faktora (faktorov), vydeliaemogo kletkami amniona cheloveka, na proliferativnuiu aktivnost' normal 'nykh i transformirovannykh fibroblastov.

The effect of FL-medium obtained upon cultivation of the human amniotic cells (FL) on the proliferative activity of intact (from spleen of C3H mice) and transformed (L-cells) fibroblasts was studied. The effect depended on the intensity of cell division: in case of high mitotic activity of fibroblasts in the control cultures FL-medium inhibited their proliferation and in case of low activity stimulated their division. It is suggested that the human amniotic cells secrete a factor (s) regulating the mitotic activity of cells in the culture medium.