1.
J Org Chem
; 85(12): 8287-8294, 2020 06 19.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32431150
RESUMO
Three different modes of aldehyde/alkyne assembly through a controlled radical reaction are devised. While a double C-H activation/annulation leads to indenones, a concurrent oxidation of both aldehydes and alkynes in the course of their connection offers aroyloxy ketones. Besides two types of cascade reactions starting from identical materials, through a phenylpropiolic acid substrate, a cascade three C-C bond formation via an uninterrupted C-H functionalization/annulation/decarboxylative aroylation as a formidable challenge in radical reactions occurs to deliver 2-aroyl-3-aryl indenones.