[Current view on Blastocystis species: clinical forms, diagnosis and treatment].

The symptomatic form of Blastocystis spp. infection not only with mild diarrhea or dysentery-like syndrome, but also with the development of severe ulcerative necrotic lesions of the intestine. Meanwhile, the pathogenicity of these microorganisms should not be exaggerated, due to majority asymptomatic cases or infection transmission with minor impaired bowel function.

[Human babesiosis: clinical cases in the european part of the Russian Federation].

The article describes four clinical observations of patients with babesiosis detected in the European part of the Russian Federation, two of whom were under the direct supervision of the authors. The analysis of epidemiological data, clinical picture, results of laboratory studies in the dynamics of the disease. Differential diagnosis and treatment are discussed.

Opportunistic diseases in patients with HIV infection in the intensive care unit.

AIM: The aim of the study was to analyze the incidence and prevalence of opportunistic diseases and comorbidities in patients admitted in the intensive care unit. MATERIALS AND METHODS: A specialized intensive care unit (ICU) for patients with severe HIV infection was set up in 2014 at the infectious diseases 2nd state hospital Moscow. It provides intensive care and treatments for HIV patients with severe co-morbidities and opportunistic infections. Retrospective analysis of medical records from 2014-2016 was carried out. Also carried out was a comparative study of the most common presentation of secondary diseases with available data of HIV patients in Russia from 1993-1997. RESULTS: The number of patients treated increased from 455 to 852, and the death rate in the department decreased from 64.8 to 50.2% since it began operating. The opportunistic infections noted were cytomegalovirus, pneumocystis pneumonia, esophageal candidiasis, tuberculosis and toxoplasmosis of the brain. The most common comorbidities were chronic hepatitis C and mixed form of chronic hepatitis with cirrhosis complications. Despite the vast diagnostic possibilities, bacterial pneumonia and encephalitis of unknown origin significantly occurred. Comparative study of secondary disease since the early 1990s revealed a significant increase in cerebral toxoplasmosis (from 1.7 to 10.4%), pneumocystis pneumonia (from 5.2 to 16.0%) and encephalitis of unspecified etiology (from 13.8 to 39.4%). CONCLUSION: Disease severity among HIV patients is increasing. CMV and pneumocystis pneumonia were predominant opportunistic diseases. There were significant changes in the presentation of secondary diseases compared to data from 1993-1997.

[Current treatment methods for malaria patients]. / Sovremennye metody lecheniia bol'nykh maliariei.

The paper gives a review of present-day drugs effective against malaria, provides the result of a clinical trial of melloquine, fansidar, fansimeph, chlorochine in diverse malaria forms. The choice of the drug should be individual, basing on the disease severity, form and resistance of tropical malaria causative agent.

[The treatment of patients with imported helminthiases]. / Lechenie bol'nykh zavoznymi gel'mintozami.

The authors treated helminth infestation in 856 patients who have arrived to Russia from tropical countries. Early diagnosis and treatment of helminthiasis in such patients reduce their susceptibility to other diseases in the course of relevant adaptation to new climatic conditions. The authors point to high efficacy of the drugs mebendazol, albendazol, medaminol (against ancylostomiasis, ascariasis, trichocephaliasis), praziquantel (against schistosomiasis and hymenolepiasis).

[Significance of an increase in the titer of agglutinins in the microagglutination test in leptospirosis]. / K voprosu o znachenii velichiny titra aggliutininov v reaktsii microaggliutinatsii pri leptospiroze

The authors considered different views of investigators on the diagnostic antibody titre level in the microagglutination test (MAT) in leptospirosis of man and animals. Some of them took into consideration MAT in low titres (1:10-1:20), and others - in high only (1:400, 1:1000), which gave no possibility to assess the state of leptospirosis morbidity. The authors suggest that the assessment of the level of the titres in single and repeated studies should be approached differentially. In single examination 1:100 and over should be considered as a positive MAT titre for man, 1:200 and over - for cattle, 1:20 and over - for swine, and 1:20 and over for murine rodents. In repeated investigations any level of the titre in case of its dynamics should be taken into consideration.