1.
RSC Adv
; 12(46): 30120-30124, 2022 Oct 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-36329948
RESUMO
A concise synthesis of molnupiravir in a one-pot two-step approach starting from uridine is described. Formally, herein, two sets of one-pot two-reaction steps introducing simplicity for purifications and using chemically available reagents are presented. In this context, molnupiravir was obtained in up to 68% overall yield and multigram-scale. In addition, HPLC analysis showed the molnupiravir purity above 99%.