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J Neurol Neurosurg Psychiatry ; 81(4): 423-7, 2010 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-19965856

RESUMO

Background Focal spasticity is a significant motor disorder following stroke, and Botulinum Toxin Type-A (BoNT-A) is a useful treatment for this. The authors evaluated kinematic modifications induced by spasticity, and whether or not there is any improvement following injection of BoNT-A. Methods Eight patients with stroke with upper-limb spasticity, showing a flexor pattern, were evaluated using kinematics before and after focal treatment with BoNT-A. A group of sex- and age-matched normal volunteers acted as a control group. Results Repeated-measures ANOVA showed that patients with stroke performed more slowly than the control group. Following treatment with BoNT-A, there was a significant improvement in kinematics in patients with stroke, while in the control group, performance remained unchanged. Conclusions Focal treatment of spasticity with BoNT-A leads to an adaptive change in the upper limb of patients with spastic stroke.


Assuntos
Fenômenos Biomecânicos/efeitos dos fármacos , Fenômenos Biomecânicos/fisiologia , Toxinas Botulínicas Tipo A/farmacocinética , Toxinas Botulínicas Tipo A/uso terapêutico , Fármacos Neuromusculares/farmacocinética , Fármacos Neuromusculares/uso terapêutico , Espasmo , Acidente Vascular Cerebral/complicações , Extremidade Superior/fisiopatologia , Toxinas Botulínicas Tipo A/administração & dosagem , Feminino , Humanos , Injeções Intramusculares , Masculino , Pessoa de Meia-Idade , Fármacos Neuromusculares/administração & dosagem , Espasmo/tratamento farmacológico , Espasmo/etiologia , Espasmo/fisiopatologia
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