RESUMO
The novel betacoronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a worldwide pandemic (COVID-19) after emerging in Wuhan, China. Here we analyzed public host and viral RNA sequencing data to better understand how SARS-CoV-2 interacts with human respiratory cells. We identified genes, isoforms and transposable element families that are specifically altered in SARS-CoV-2-infected respiratory cells. Well-known immunoregulatory genes including CSF2, IL32, IL-6 and SERPINA3 were differentially expressed, while immunoregulatory transposable element families were upregulated. We predicted conserved interactions between the SARS-CoV-2 genome and human RNA-binding proteins such as the heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) and eukaryotic initiation factor 4 (eIF4b). We also identified a viral sequence variant with a statistically significant skew associated with age of infection, that may contribute to intracellular host-pathogen interactions. These findings can help identify host mechanisms that can be targeted by prophylactics and/or therapeutics to reduce the severity of COVID-19.
Assuntos
COVID-19/genética , Biologia Computacional/métodos , Interações Hospedeiro-Patógeno/genética , Pandemias , SARS-CoV-2/genética , Sítios de Ligação , COVID-19/virologia , Citocinas/genética , Bases de Dados Genéticas , Regulação da Expressão Gênica , Genoma Viral , Humanos , RNA Viral/genética , RNA Viral/metabolismo , Proteínas de Ligação a RNA/genética , Proteínas de Ligação a RNA/metabolismo , RNA-Seq , Serpinas/genética , Transdução de Sinais/genética , Transcriptoma , Replicação Viral/genéticaRESUMO
Desde el Centro de Rehabilitación Psicosocial ("CRPS") Los Cármenes (inscrito dentro de la Red Pública de Atención Social para Personas con Enfermedad Mental Grave y Duradera, dependiente de la Consejería de Familia y Asuntos Sociales de la Comunidad de Madrid (www.comunidad.org); gestionado por Instituto de Trabajo Social y Servicios Sociales (INTRESS), se desarrolla desde el 2004 un proyecto que consiste en la realización del programa de radio comunitaria "Ábrete Camino". La metodología, basada en los valores clave de la recuperación, permite que los/as participantes sean cada vez más protagonistas, tanto en el programa como en sus vidas. Ellos/as mismos/as nos cuentan su experiencia a través de un debate en directo en una de sus emisiones. Valoran la experiencia como muy positiva, siendo una actividad significativa en su proyecto vital.(AU)
From the Center for Psychosocial Rehabilitation ("CRPS") Los Cármenes (registered in the Public Network of Social Care for People with Severe and Enduring Mental Illness, under the Ministry of Family and Social Affairs of the Community of Madrid, operated by Intress ), developed since 2004 a project that consists in making community radio program " Ábrete Camino". The methodology, based on the core values of the recovery, allowing the participants to be increasingly more players in both the program and in their lives. They have experience through a live debate in one of their broadcasts.(AU)
Assuntos
Rádio , Serviços de Reabilitação , Serviços de Saúde Mental , Serviços Comunitários de Saúde Mental , EspanhaRESUMO
Desde el Centro de Rehabilitación Psicosocial ("CRPS") Los Cármenes (inscrito dentro de la Red Pública de Atención Social para Personas con Enfermedad Mental Grave y Duradera, dependiente de la Consejería de Familia y Asuntos Sociales de la Comunidad de Madrid (www.comunidad.org); gestionado por Instituto de Trabajo Social y Servicios Sociales (INTRESS), se desarrolla desde el 2004 un proyecto que consiste en la realización del programa de radio comunitaria "Ábrete Camino". La metodología, basada en los valores clave de la recuperación, permite que los/as participantes sean cada vez más protagonistas, tanto en el programa como en sus vidas. Ellos/as mismos/as nos cuentan su experiencia a través de un debate en directo en una de sus emisiones. Valoran la experiencia como muy positiva, siendo una actividad significativa en su proyecto vital.
From the Center for Psychosocial Rehabilitation ("CRPS") Los Cármenes (registered in the Public Network of Social Care for People with Severe and Enduring Mental Illness, under the Ministry of Family and Social Affairs of the Community of Madrid, operated by Intress ), developed since 2004 a project that consists in making community radio program " Ábrete Camino". The methodology, based on the core values of the recovery, allowing the participants to be increasingly more players in both the program and in their lives. They have experience through a live debate in one of their broadcasts.