Toward the European Health Data Space: The IMPaCT-Data secure infrastructure for EHR-based precision medicine research.

BACKGROUND: Art. 50 of the proposal for a Regulation on the European Health Data Space (EHDS) states that "health data access bodies shall provide access to electronic health data only through a secure processing environment, with technical and organizational measures and security and interoperability requirements". OBJECTIVE: To identify specific security measures that nodes participating in health data spaces shall implement based on the results of the IMPaCT-Data project, whose goal is to facilitate the exchange of electronic health records (EHR) between public entities based in Spain and the secondary use of this information for precision medicine research in compliance with the General Data Protection Regulation (GDPR). DATA AND METHODS: This article presents an analysis of 24 out of a list of 72 security measures identified in the Spanish National Security Scheme (ENS) and adopted by members of the federated data infrastructure developed during the IMPaCT-Data project. RESULTS: The IMPaCT-Data case helps clarify roles and responsibilities of entities willing to participate in the EHDS by reconciling technical system notions with the legal terminology. Most relevant security measures for Data Space Gatekeepers, Enablers and Prosumers are identified and explained. CONCLUSION: The EHDS can only be viable as long as the fiduciary duty of care of public health authorities is preserved; this implies that the secondary use of personal data shall contribute to the public interest and/or to protect the vital interests of the data subjects. This condition can only be met if all nodes participating in a health data space adopt the appropriate organizational and technical security measures necessary to fulfill their role.

Traditional Atlantic Diet and Its Effect on Health and the Environment: A Secondary Analysis of the GALIAT Cluster Randomized Clinical Trial.

Importance: The universal call to action for healthier and more sustainable dietary choices is the framework of the United Nations's Sustainable Development Goals. The Atlantic diet, originating from the northwest of the Iberian Peninsula, represents an example of a traditional diet that aligns with these principles. Objective: To explore a 6-month intervention based on the Atlantic diet's effects on metabolic and environmental health, assessing metabolic syndrome (MetS) incidence and the carbon footprint. Design, Setting, and Participants: The Galician Atlantic Diet study was a 6-month randomized clinical trial designed to assess the effects of this regional traditional diet on families' eating habits. The study was conducted from March 3, 2014, to May 29, 2015, at a local primary health care center in the rural town of A Estrada in northwestern Spain and involved a multisectoral collaboration. Families were randomly selected from National Health System records and randomized 1:1 to an intervention or control group. This secondary analysis of the trial findings was performed between March 24, 2021, and November 7, 2023. Interventions: Over 6 months, families in the intervention group received educational sessions, cooking classes, written supporting material, and foods characteristic of the Atlantic diet, whereas those randomized to the control group continued with their habitual lifestyle. Main Outcomes and Measures: The main outcomes were MetS incidence, defined per National Cholesterol Education Program Adult Treatment Panel III guidelines, and carbon footprint emissions as an environmental metric using life cycle assessment with daily dietary intake as the functional unit. Results: Initially, 250 families were randomized (574 participants; mean [SD] age, 46.8 [15.7] years; 231 males [40.2%] and 343 females [59.8%]). The intervention group included 126 families (287 participants) and the control group, 124 families (287 participants). Ultimately, 231 families completed the trial. The intervention significantly reduced the risk of incident cases of MetS (rate ratio, 0.32; 95% CI, 0.13-0.79) and had fewer MetS components (proportional odds ratio, 0.58; 95% CI, 0.42-0.82) compared with the control condition. The intervention group did not have a significantly reduced environmental impact in terms of carbon footprint emissions compared with the control group (-0.17 [95% CI, -0.46 to 0.12] kg CO2 equivalents/person/d). Conclusions and Relevance: These findings provide important evidence that a family-focused dietary intervention based on a traditional diet can reduce the risk of incident MetS. Further research is needed to understand the underlying mechanisms and determine the generalizability to other populations, taking into account regional cultural and dietary variations. Trial Registration: ClinicalTrials.gov Identifier: NCT02391701.

Environmental and economic benefits of wheat and chickpea crop rotation in the Mediterranean region of Apulia (Italy).

Wheat plays an essential role in safeguarding global food security. However, its intensive agricultural production, aimed at maximizing crop yields and associated economic benefits, jeopardizes many ecosystem services and the economic stability of farmers. Rotations with leguminous are recognized as a promising strategy in favor of sustainable agriculture. However, not all crop rotations are suitable for promoting sustainability and their implications on agricultural soil and crop quality should be carefully analyzed. This research aims to demonstrate the environmental and economic benefits of introducing chickpea into a wheat-based system under Mediterranean pedo-climatic conditions. For this purpose, the crop rotation "wheat-chickpea" was evaluated and compared with the conventional regime (wheat monoculture) by means of life cycle assessment methodology. For this purpose, inventory data (e.g., agrochemical doses, machinery, energy consumption, production yield, among others) was compiled for each crop and cropping system, thus converted into environmental impacts based on two functional units: 1 ha per year and one € of gross margin. Eleven environmental indicators were analyzed, including soil quality and biodiversity loss. Results indicate that chickpea-wheat rotation system offers lower environmental impacts, regardless of the functional unit considered. Global warming (18 %) and freshwater ecotoxicity (20 %) were the categories with the largest reductions. Furthermore, a remarkable increase (96 %) in gross margin was observed with the rotation system, due to the low cost of chickpea cultivation and its higher market price. Nevertheless, proper fertilizer management remains essential to fully attain the environmental benefits of crop rotation with legumes.

Gender identity and sexual orientation of people with autism spectrum disorder: a systematic review / Identidad de género y orientación sexual de las personas con Trastorno del Espectro del Autismo: una revisión sistemática

There has been growing interest about gender identity and sexual orientation in people with autism spectrum disorder. This systematic review analyses 18 studies conducted since 2016 that met the inclusion criteria. The aim was to gather evidence of gender identity, gender dysphoria, and sexual orientation in the ASD population. The results indicate an increased prevalence of non-conforming gender identity and gender dysphoria in people with ASD. There was also evidence of greater prevalence of non-heterosexual orientation in people with ASD than people without ASD. These results were particularly found in women with ASD. However, more studies are needed, especially about women, children and adolescents, to ensure that there are suitable support and resources to meet the needs of this population. (AU)

En los últimos años ha surgido un creciente interés en relación con la identidad de género y la orientación sexual de las personas con trastorno del espectro del autismo (TEA). La presente revisión sistemática analiza un total de 18 estudios, publicados a partir de 2016, con la finalidad de obtener evidencias acerca de la identidad y disforia de género, y la orientación sexual en la población con TEA. Los resultados indicaron que existe una mayor prevalencia de identidad de género no conforme y de disforia de género en la población con TEA. Se encontró una mayor prevalencia de orientación no heterosexual en las personas con TEA en comparación con la población sin TEA. Estos resultados se encuentran preferentemente en las mujeres con TEA. No obstante, es necesario disponer de más y mejores evidencias sobre esta temática, especialmente en mujeres, y en las etapas de la niñez y la adolescencia, con el fin de implementar apoyos y recursos adecuados para dar respuesta a las necesidades de estas personas. (AU)

Improving environmental sustainability of agriculture in Egypt through a life-cycle perspective.

Soil plays an essential role as a habitat, source of nutrients and support for vegetation. Promoting food security and environmental sustainability of agricultural systems requires an integrated approach to soil fertility management. Agricultural activities should be developed with preventive approaches aimed at avoiding or reducing negative impacts on the soil physicochemical and biological properties and the depletion of soil nutrient reserves. In this regard, Egypt has developed the Sustainable Agricultural Development Strategy to encourage environmentally friendly practices among farmers, such as crop rotation and water management, in addition to extending agriculture to desert areas, favoring the socio-economic development of the region. In order to evaluate the outcomes of the plan beyond quantitative data of production, yield, consumption and emissions, the environmental profile of agriculture in Egypt has been assessed under a life-cycle perspective in order to identify the associated environmental burdens and ultimately contribute to improving the sustainability policies of agricultural activity within the framework of a crop rotation system. In particular, a two-year crop rotation (Egyptian clover-maize-wheat) was analyzed in two distinct agricultural areas in Egypt: New Lands in desert regions and Old Lands along the Nile River, traditionally recognized as fertile areas due to the river alluvium and water availability. The New Lands had the worst environmental profile for all impact categories, except for Soil organic carbon deficit and Global potential species loss. Irrigation and on-field emissions associated with mineral fertilization were identified as the most critical hotspots of Egyptian agriculture. In addition, land occupation and land transformation were reported as the main drivers of biodiversity loss and soil degradation, respectively. Beyond these results, further research on biodiversity and soil quality indicators is needed to more accurately assess the environmental damage caused by the conversion of deserts into agricultural areas, given the species richness these regions hold.

Benchmarking machine learning approaches to predict radiation-induced toxicities in lung cancer patients.

Background and purpose: Radiation-induced toxicities are common adverse events in lung cancer (LC) patients undergoing radiotherapy (RT). An accurate prediction of these adverse events might facilitate an informed and shared decision-making process between patient and radiation oncologist with a clearer view of life-balance implications in treatment choices. This work provides a benchmark of machine learning (ML) approaches to predict radiation-induced toxicities in LC patients built upon a real-world health dataset based on a generalizable methodology for their implementation and external validation. Materials and Methods: Ten feature selection (FS) methods were combined with five ML-based classifiers to predict six RT-induced toxicities (acute esophagitis, acute cough, acute dyspnea, acute pneumonitis, chronic dyspnea, and chronic pneumonitis). A real-world health dataset (RWHD) built from 875 consecutive LC patients was used to train and validate the resulting 300 predictive models. Internal and external accuracy was calculated in terms of AUC per clinical endpoint, FS method, and ML-based classifier under analysis. Results: Best performing predictive models obtained per clinical endpoint achieved comparable performances to methods from state-of-the-art at internal validation (AUC ≥ 0.81 in all cases) and at external validation (AUC ≥ 0.73 in 5 out of 6 cases). Conclusion: A benchmark of 300 different ML-based approaches has been tested against a RWHD achieving satisfactory results following a generalizable methodology. The outcomes suggest potential relationships between underrecognized clinical factors and the onset of acute esophagitis or chronic dyspnea, thus demonstrating the potential that ML-based approaches have to generate novel data-driven hypotheses in the field.

Water-Energy-Food nexus index proposal as a sustainability criterion on dairy farms.

Cow milk is a fundamental nutrients source for the human diet at all stages of life. However, the decline in cow milk consumption over the years has been driven by increased consumer awareness of animal welfare and the environmental burdens associated. In this regard, different initiatives have emerged to mitigate the impacts of livestock farming, but many of them without addressing the multi-perspective view of environmental sustainability. Thus, the Water-Energy-Food (WEF) nexus emerges as a framework to consider the complex synergies among carbon emissions, water demand, energy requirements and food production. In this study, a novel and harmonised WEF nexus approach has been proposed and applied to evaluate a set of 100 dairy farms. For that, the assessment, normalisation, and weighting of three lifecycle indicators such as carbon, water and energy footprints, as well as the milk yield were carried out to obtain a single value, the WEF nexus index (WEFni), which varies from 0 to 100. Results show that the WEF nexus scores obtained vary from 31 to 90, demonstrating large differences among the farms assessed. A cluster ranking was performed to identify those farms with the worst WEF nexus indexes. For this group, consisting of 8 farms with an average WEFni of 39, three improvement actions focused on the feeding, digestive process and wellbeing of the cows were applied to determine the potential reduction in the two main hotspots identified: cow feeding and milk production level. The proposed methodology can establish a roadmap for promoting a more environmentally sustainable food industry, although further studies are still required in the pathway of a standardised WEFni.

Notch Partners in the Long Journey of T-ALL Pathogenesis.

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological disease that arises from the oncogenic transformation of developing T cells during T-lymphopoiesis. Although T-ALL prognosis has improved markedly in recent years, relapsing and refractory patients with dismal outcomes still represent a major clinical issue. Consequently, understanding the pathological mechanisms that lead to the appearance of this malignancy and developing novel and more effective targeted therapies is an urgent need. Since the discovery in 2004 that a major proportion of T-ALL patients carry activating mutations that turn NOTCH1 into an oncogene, great efforts have been made to decipher the mechanisms underlying constitutive NOTCH1 activation, with the aim of understanding how NOTCH1 dysregulation converts the physiological NOTCH1-dependent T-cell developmental program into a pathological T-cell transformation process. Several molecular players have so far been shown to cooperate with NOTCH1 in this oncogenic process, and different therapeutic strategies have been developed to specifically target NOTCH1-dependent T-ALLs. Here, we comprehensively analyze the molecular bases of the cross-talk between NOTCH1 and cooperating partners critically involved in the generation and/or maintenance and progression of T-ALL and discuss novel opportunities and therapeutic approaches that current knowledge may open for future treatment of T-ALL patients.

Environmental performance of rainbow trout (Oncorhynchus mykiss) production in Galicia-Spain: A Life Cycle Assessment approach.

Aquaculture is an increasingly important supplier of food worldwide. However, due to its high dependence on agricultural and fishing resources, its growth is constantly constrained by environmental impacts beyond aquaculture production systems. Within the European Union, Spain accounts for approximately 25 % of total aquaculture production, which implies that environmental impacts in rivers and marine ecosystems must be monitored to understand the role of aquaculture systems. While studies on the environmental performance of mussels or turbot production have been reported in the literature, Spanish rainbow trout (Oncorhynchus mykiss) has not received much attention despite its relative importance. In this sense, a Life Cycle Assessment (LCA) study of rainbow trout produced in a medium-sized plant in Galicia (NW Spain) was carried out in the present study. The study considered the production of round weight trout, as well as some commonly produced processed products, including filleting. The life cycle modelling included a high level of primary data in the foreground system. In addition to the widely considered environmental impact categories for this activity (e.g., global warming potential, terrestrial acidification and freshwater eutrophication), the recent proposed antibiotic resistance (ABR) enrichment impact category was included to explore the potential impact of antibiotic release in freshwater microbiota. The results highlighted the high contribution of aquafeed to most impact categories, due to upstream agricultural and fishing processes, whereas farm operation was responsible for the larger part of the impact in freshwater eutrophication, mainly due to direct emissions of nutrients from fish feeding. Amoxicillin release to recipient water bodies was the main driver to the ABR enrichment category. In contrast, the processing phase (i.e., gutting, freezing and packaging) showed low environmental burdens. In order to improve the environmental performance of the rainbow trout production system, decreasing the feed conversion ratio (FCR), shifting to renewable energy, using low environmental burden ingredients in aquafeed, and alternatives to control diseases without antibiotics could be considered.

Offsetting the environmental impacts of single or multi-product biorefineries from wheat straw.

Moving toward a bioeconomy system is fundamental to climate change mitigation, nevertheless, the biotechnological routes should guarantee an environmental sustainability. Isobutene, a precursor in several industrial applications, is one of those chemicals that the environmental effects of its bio-based production have been scarcely explored. This study aims to assess the environmental performance of two biorefinery systems: the first one focuses only on the production of isobutene (I) and the second one on the co-production with lignin (I + L), both from the valorisation of wheat straw. The Life Cycle Assessment methodology is used to determine the environmental impacts considering mid-point and end-point categories. Biorefineries report 0.65 and 1.32 kg CO2-eq per kg of biomass processed for I and I + L system, respectively. The most affected endpoint damage category corresponds to Human Health, regardless of the scenarios. Moreover, the pre-treatment stage constitutes the main hotspot of both systems considering midpoint and endpoint perspectives.

Determining the environmental and economic implications of lupin cultivation in wheat-based organic rotation systems in Galicia, Spain.

Crop rotation represents a potentially sustainable strategy to address environmental problems of intensive agricultural practices, such as soil degradation, biodiversity reduction, and greenhouse gas emissions. This manuscript assesses the environmental and economic implications of introducing lupin cultivation into winter wheat-based rotation systems under an organic regime in Galicia, Spain. Life Cycle Assessment methodology was used to determine the environmental impacts of three rotation systems over a six-year period: lupin → wheat → rapeseed (OA1), lupin → potato → wheat (OA2), and lupin → wheat → rapeseed ‖ maize (OA3). For a robust assessment, three functional units were applied: land management (ha), economic indicator (gross margin in euros) and protein content (1 kg of protein-corrected grain). Moreover, the environmental profiles were compared with rotation systems without lupin crop in a conventional regime. In terms of Global Warming, impacts of about 2214, 3119 and 766 kg CO2eq·ha-1 were obtained for OA1, OA2 and OA3, respectively. Moreover, OA1 is the best rotation in terms of land and protein. Meanwhile, OA2 rotation is the best choice in the economic function, as it obtained the highest level of gross margin (5708 €·ha-1). Furthermore, with the exception of acidification, organic systems are less impactful than conventional systems. Ammonia emissions from the use of manure are the reason for these higher impacts. Organic rotations OA1 and OA2 have about 6 % or 15 % less gross margin than their conventional counterparts, respectively, however, an increase of 28 % was obtained for rotation OA3. This study helps decision-makers to implement environmentally and economically viable strategies.

Blue carbon accounting as metrics to be taken into account towards the target of GHG emissions mitigation in fisheries.

The adoption of the 2030 Agenda for Sustainable Development must address the balance between sustainable growth and tackling climate change. In this context, forests can help to reduce greenhouse gas (GHG) emissions, unfortunately, equivalent solutions in the ocean are often overlooked. Moreover, the complexity in determining the real impact of fishing on the environment is not a trivial issue. Thus, the aim of this study is to broaden the scope and analyse, for the first time, the entire carbon cycle associated with the life cycle of a fish: Scomber scombrus from a fishery located in the Cantabrian Sea (Spain). From this carbon cycle assessment, it is estimated that fishing activity has prevented 871.7 t of carbon (in terms of blue carbon) from being sequestered each year. This value comes from the fraction of fish that would have died of natural causes if they had not been caught, reaching the seabed, and undergoing remineralisation processes of the carbon content of their bodies. Beyond these results, it is vital to implement a series of actions with the aim of counteracting the amount of carbon that could have been sequestered on the seabed by the natural death of the fishes if they had not been caught. To this end, it is shown that the implementation of technical improvements to the vessels, the replacement of the current fuel used and the rearrangement of shipping routes in combination with an extension in the closed fishing season and a commitment to an omnivorous diet, allows for a reduction in carbon flow of almost 90 % of the blue carbon that has been prevented from being sequestered by fisheries. A consequential approach can then identify the influence of the proposed changes on their corresponding carbon flows for use as decision criteria in regulating fisheries and environmental management policies.

Introducing lupin in autochthonous wheat rotation systems in Galicia (NW Spain): An environmental and economic assessment.

Crop diversification, as a sustainable land management practice, is a potential strategy to face soil degradation, climate change and food security, being the incorporation of legumes in cereal rotation systems, a strategy that improves soil nutrient levels. In a context of sustainable agriculture, this manuscript aims to evaluate the effect of lupin cultivation from an environmental and economic perspective in Galician winter wheat-based rotation systems. The life cycle analysis (LCA) methodology was applied for three rotation systems over a six-year period: lupin + wheat + oilseed rape (RA1), lupin + potato + wheat (RA2), and lupin + wheat + oilseed rape + maize (RA3). The general approach of this study was to collect primary data associated with the rotation crops to quantify their environmental impacts and economic benefits and to identify their advantages or disadvantages. Comparing and contrasting the environmental profiles based on three functional units: hectare land (ha), financial indicator (gross margin, €) and yield production (kg of wheat grain) allows a robust evaluation of each crop rotation system. Relating to rotations without lupin, the results indicate that for the impact categories evaluated, the introduction of lupin proved to be favourable with notable reductions of 64% and 30% in the environmental categories of Global Warming and Marine Eutrophication, respectively. Moreover, favourable economic consequences were evident in rotations RA1 and RA2 with a 19% and 51% increase in financial indicators, respectively, but with a marginal reduction of 2% in gross margin in RA3. This study motivates stakeholders to understand the environmental impacts of diversification strategies in agricultural systems and serves as a baseline to address the assessment of the social aspects of these systems for a complete sustainability perspective.

Co-benefits of the EAT-Lancet diet for environmental protection in the framework of the Spanish dietary pattern.

The immediate need to build resilient food systems with lower greenhouse gas (GHG) emissions and protection of water resources is a global challenge. To address this, the EAT-Lancet Commission described the global reference diet with principles of nutritional quality and environmental sustainability. With this in mind, the carbon and water footprints of the current Spanish dietary pattern have been compared with the EAT-Lancet global dietary recommendations, taking into account deviations in food intake. To provide additional context, differences between the average Spanish dietary pattern and dietary guidelines applied in other countries in Europe (Italy, the Netherlands and the Mediterranean region) and America have also been analyzed and discussed from a sustainability approach. We found that the EAT-Lancet diet requires less water resources (3056 L·person-1·day-1) and lower level of GHG emissions (2.13 kgCO2eq·person-1·day-1) in comparison with the Spanish dietary pattern (3732 L·person-1·day-1 and 3.62 kgCO2eq·person-1·day-1, respectively). Starch-based products and oils and fats were identified as largest contributors to both environmental indicators in the EAT-Lancet diet. On the other hand, meat and dairy were the environmental hotspots in the Spanish dietary pattern. Comparison with other food-based dietary patterns also raises environmental concerns about the high meat consumption in Spain. Overall, this analysis suggests that reducing the consumption of beef meat and dairy to a level in line with the global environmental targets set by the EAT-Lancet Commission would ensure a shift in Spanish dietary habits towards more environmentally sustainable food consumption patterns.

Environmental comparison of banana waste valorisation strategies under a biorefinery approach.

Banana wastes can be valorised in bioethanol due to its high content in cellulose (more than 30% of total on a dry basis) and hemicelluloses (25% of total). Large amount of these wastes is generated during the banana cultivation and harvesting stage. This study proposes the use of, beside conventional acid sulphuric, different organic acids (tartaric, oxalic and citric) during acid pretreatment step, to suppress the unwanted compounds formation and improve bioethanol production. Instead, bioethanol production generates a solid waste flow that is managed in an anaerobic digestion plant, obtaining biogas, to be converted into energy, and digestate, considered as a potential biofertiliser. Life cycle assessment methodology is used to analyse the environmental profiles of four valorisation scenarios to produce bioethanol from banana peel waste. According to the results, reported per kilogram of bioethanol, the citric acid-based scenario has the worst environmental profile due to the background processes involved in the acid production (around 55% for most impact categories). Conversely, the oxalic acid-based scenario has the best environmental profile, with a decrease of around 20% and 35%, depending on the impact category, compared to the citric acid scenario. The energy requirements production (mostly thermal energy) is the main hotspot in numerous subsystems regardless of the scenario (ranging from 30% to 50% depending on the impact category). Therefore, the use of renewable energy sources to satisfy energy requirements combined with an energy optimisation of the valorisation strategies through the reuse of some internal steams, is proposed as improvement activities.

Environmental assessment of the production of itaconic acid from wheat straw under a biorefinery approach.

This study performs the environmental assessment of itaconic acid (IA) production from wheat straw. The Life Cycle Assessment (LCA) methodology is used to determine the environmental hotspots, considering impact categories such as Global Warming (GW), Fossil Resource Scarcity (FRS), Water Consumption (WC), among others. A sensitivity analysis was performed considering an optimization of the steam explosion process and 100% renewable energy. Results report an impact of about 14.33 kg CO2 eq in GW, 4.15 kg of oil eq in FRS, for each kg of IA produced for the baseline scenario. Moreover, the pretreatment and fermentation stages constitute hotspots of the IA production. In addition, using a renewable energy source in production would reduce the impact by 82% in GW, 71% in PM and 82% in FRS categories. The optimization of the steam explosion process presents a better performance in GW and FRS but also lies in an increase in WC.

Driving commitment to sustainable food policies within the framework of American and European dietary guidelines.

Diet and nutrition are essential factors in promoting good health throughout life. Their role as determinants of chronic non-communicable diseases is widely recognized. Additionally, the demand for food involves relevant environmental burdens that have to be taken into account on the way to achieving the Sustainable Development Goals. As an important part of nutrition policy, food-based dietary guidelines (FBDGs) have been revised. The key question is: Are environmental considerations being incorporated into them? To address this issue, we modeled and compared both the main environmental indicators in terms of carbon footprint (CF) and water footprint (WF), and nutritional quality (according to the Nutrient Rich Diet index, NRD9.3 and a health gain score) of dietary guidelines from Northern and Southern Europe and America. Particularly, the FBDGs compared were Dutch Dietary Guidelines (DDG), New Nordic Diet (NND), Spanish Strategy for Nutrition, Physical Activity and Obesity Prevention (NAOS), Mediterranean Diet (MD), Italian Dietary Guidelines (IDG) and American Dietary Guidelines (DGA). The IDG and MD offered the best profiles from a climate change perspective (2.04 and 2.21 kgCO2eq·day-1). Overall, DGA had the highest CF (2.98 kgCO2eq·day-1). WF presented greater fluctuations, not only due to daily-recommended amounts, but also because of different climate conditions and production systems of the reference countries. Hence, WF ranged from 1760 L·person-1·day-1 in IDG to 3181 L·person-1·day-1 in NAOS. Finally, the nutritional value of MD, which had the highest NRD9.3 (477) and health gain score (178), has been demonstrated when the comparison was made with DDG, the one with the lowest health gain score (97) and DGA, the worst in terms of NRD9.3 (391). To go ahead of the FBDGs that bet on all dimensions of sustainability, multi-criteria analysis is needed. Nutrition and environmental performance are not the only aspects of the problem; economy and sociocultural variables should be considered.

How decentralized treatment can contribute to the symbiosis between environmental protection and resource recovery.

Challenges associated with the sustainability of the water cycle pose new opportunities for resource recovery and greater environmental protection. While centralized wastewater treatment plants must evolve in their design and operation to adapt to a scenario of increasing demand for water, resources and energy, the decentralized approach emerges as an option to be considered in small communities or developing residential areas where bioenergy production can be improved through the recovery of organic matter in segregated streams or where the investment in the sewer network for connection to a centralized facility may be technologically or economically unfeasible. The main objective of this work is to evaluate the environmental and economic profile of a hybrid-decentralized configuration for the purpose of efficient wastewater management and resource recovery and its comparative evaluation with the centralized treatment scenario. Beyond water reclamation, decentralized treatment offers the possibility of valorization of digestate streams as nutrient sources for horticultural or ornamental crops in the vicinity of the plant. Based on the results of the environmental profile, this manuscript shows that the decentralized treatment approach is in line with the philosophy and guidelines of the circular economy, as it allows the use of reclaimed water and biofertilizers under safe and environmental-friendly conditions.

Environmental footprint of critical agro-export products in the Peruvian hyper-arid coast: A case study for green asparagus and avocado.

Peru has become one of the world's main agricultural hubs for a wide range of fruits and vegetables. Two of these products, avocado and green asparagus, have raised attention in recent years in the international scene from an environmental perspective due to the high amounts of water they require, as well as the long air and marine freighting distances to export these products to Europe, Asia or the US. Consequently, the aim of the current study was to perform an environmental assessment of these two products using two life-cycle methods: carbon and water footprint. For the latter, water scarcity, acidification, eco-toxicity and eutrophication impact categories have been selected for assessment. Inventory data were gathered from six different companies located in different regions of the hyper-arid Peruvian coast. The results report that the products are not carbon intensive and are in line with other similar plant-based products. Conversely, the hyper-arid conditions of the cultivation sites require a large volume of groundwater to fulfill the needs of the crops. Interestingly, even though this may lead to overexploitation of groundwater resources in the absence of appropriate management policies, the low mobility of pollutants, namely pesticides, constitutes a natural barrier to protect the degradation of natural water bodies. Similarly, highly technified irrigation systems have allowed minimizing the amounts of water used per hectare. In conclusion, results from this study may be useful in more concise environmental assessment studies on food products and diets, considering the consumption of these Peruvian products in many countries in the world. Furthermore, results are also important at regional level since they depict the carbon and water performance of these products and can also be accompanied by cross-cutting certification schemes, including Product Environmental Footprint Category Rules Guidance.

Multi-product strategy to enhance the environmental profile of the canning industry towards circular economy.

The sustainable and continued production of enough food to feed the entire world's population is one of the main concerns in the food industry. Spain, and in particular Galicia, which is an eminently fishing region characterised by the consumption of large quantities of fish, both fresh and processed, must face the challenge of shifting its seafood productive fabric towards a circular economy. To achieve this objective, the first task is to demonstrate that circular economy principles allow to reduce the environmental impacts associated with seafood production. In this sense, this study proposes the environmental evaluation of the skipjack tuna (Katsuwonus pelamis) value chain within a canning industry located in Galicia through the LCA methodology from an attributional perspective, including the valorisation processes for biowaste (edible and inedible by-products). Results indicate that the main crucial subsystems of the value chain are tuna fishing and the canning process, as it was expected considering other similar studies on seafood products. Moreover, this specific case study demonstrates that the multi-product strategy applied to the canning sector is environmentally viable. Thus, although the environmental impacts of the entire system are increased by including further valorisation operations, the environmental loads assigned to the main product (canned tuna) decrease compared to the one-product system by assigning environmental burdens to other value-added products (tuna pâté, fishmeal, and fish oil).