RESUMO
The effect of hypothalamic phospholipids on the maturation of foetal lung was investigated in a series of experiments in rabbits. Sixteen pregnant does were injected with hypothalamic phospholipids (2 mg day-1 kg-1) from day 21 of gestation. A second group of 16 does was injected with saline, and served as controls. The foetuses were delivered at gestational ages between 27 and 28 days by means of caesarean section under intravenous pentothal anaesthesia. Foetuses born from treated mothers were more active, breathed better, and their lungs expanded to a greater extent compared with the foetuses born to control mothers. In the animals of treated mothers there was, on electron microscopy, evidence of accelerated maturation of alveolar epithelial cells.
Assuntos
Hipotálamo , Pulmão/embriologia , Fosfolipídeos/farmacologia , Animais , Citoplasma/ultraestrutura , Feminino , Pulmão/fisiologia , Pulmão/ultraestrutura , Gravidez , Alvéolos Pulmonares/ultraestrutura , CoelhosRESUMO
1) Cholesterol - enriched diet induces changes in the phospholipid fatty acids of particulate fractions and modifications in the membrane-bound enzyme: 2) BC-PL (100 mg/kg i.p., as shown in rabbits) prevent cholesterol-induced modifications at brain level: 3)BC-PL (100 mg/kg i.v., as shown in mice) have a recovery effect on the cholesterol-induced modification at brain level; 4) It is suggested that some atherosclerotic lesions are analogous to those reproduced by anoxia; 5) It is suggested that the effect of BC-PL is a direct action at the level of the brain cellular membranes.
Assuntos
Encéfalo/metabolismo , Colesterol na Dieta , Fosfolipídeos/farmacologia , Adenosina Trifosfatases/metabolismo , Animais , Arteriosclerose/prevenção & controle , Comportamento Animal/efeitos dos fármacos , Peso Corporal , Encéfalo/efeitos dos fármacos , Encéfalo/enzimologia , Membrana Celular/efeitos dos fármacos , Membrana Celular/enzimologia , Colesterol/sangue , Colesterol/farmacologia , AMP Cíclico/metabolismo , Dieta Aterogênica , Ativação Enzimática/efeitos dos fármacos , Fígado/metabolismo , Magnésio/farmacologia , Camundongos , Tamanho do Órgão , Potássio/farmacologia , Coelhos , Sódio/farmacologiaAssuntos
Adenosina Trifosfatases/metabolismo , Arteriosclerose/enzimologia , Encéfalo/enzimologia , Fosfotransferases/metabolismo , Animais , Aorta/análise , Peso Corporal , Química Encefálica , Permeabilidade da Membrana Celular , Córtex Cerebral/enzimologia , Córtex Cerebral/ultraestrutura , Colesterol/análise , Cromatografia Gasosa , Cromatografia em Camada Fina , Dieta Aterogênica , Fígado , Microssomos/enzimologia , Tamanho do Órgão , Fosfolipídeos/análise , Proteínas/análise , Piridoxal/metabolismo , CoelhosRESUMO
Gamma-aminobutyric acid (GABA) values were determined in 4 groups of Sprague-Dawley rats 45-50 days after end-to-side porto-cava (PC), mesentericosplenic-cava (MSC) and mesenteric-cava (MC) anastomosis, and a false operation (FO) respectively. Values were significantly increased in the anastomosed animals. If, as may be supposed, this finding points to altered cerebral metabolism, its observation in the MSC and MC groups militates against the general view that encephalopathy in the experimental animal only occurs as a result of total deviation of the portal flow.
