1.
Cold Spring Harb Perspect Biol
; 2(5): a002279, 2010 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20452964
RESUMO
ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events involved in initiating T-cell responses by the antigen receptor. Here we review the structure of ZAP-70, its regulation, its role in development and in disease. We also describe a model experimental system in which ZAP-70 function can be interrupted by a small chemical inhibitor.