A survey of perioperative management of sickle cell disease in North America.

BACKGROUND: Children with sickle cell disease frequently undergo surgical procedures that are associated with acute exacerbations of the disease. Current perioperative management practices are unclear. OBJECTIVES: We aimed at describing the current management. METHODS: We conducted an electronic survey of North American members of the Society for Pediatric Anesthesia, in which we asked about their perioperative management of sickle cell disease. RESULTS: The response rate to valid addresses was 25% (n=510/2006). In four scenarios, (a patient with mild disease undergoing a minor procedure; a patient with mild disease undergoing a more invasive procedure; a patient with severe disease undergoing a minor procedure; and a patient with severe disease undergoing a more invasive procedure) 80%, 38%, 27%, and 16% of respondents, respectively, would rely on oral fluids to hydrate patients during the preoperative fast, while 13%, 34%, 44%, and 59%, respectively, would use intravenous fluid. For the same four scenarios, 64%, 28%, 33%, and 10%, respectively, would not transfuse patients in an attempt to prevent sickle cell exacerbations, while 17%, 49%, 36%, and 51%, respectively, would transfuse to a hemoglobin concentration of 10 g·dl(-1). The tendencies to administer preoperative intravenous fluid and to transfuse blood increased with disease severity and procedure invasiveness (P<0.001). Although 89% felt comfortable managing patients with sickle cell disease, 73% thought an advisory statement on optimal perioperative management was needed. CONCLUSIONS: There is a wide variation in the management of children with sickle cell disease. Clinicians differentiate management based on disease severity and procedure type.

The effect of a 3 : 1 volume mixture of propofol 1% and thiopental 2.5% in reducing the pain on injection of propofol in children.

BACKGROUND: In this prospective, randomized, double-blind, controlled trial, our primary objective was to assess the effect of a 3 : 1 mixture of propofol and thiopental in reducing pain on injection in children. Our hypothesis was that a 3 : 1 mixture of propofol and thiopental (treatment) would reduce the incidence of pain on injection to 20% compared to the expected incidence of 40% in the control group of an 11 : 1 mixture of propofol and 2% lidocaine. METHODS: Study subjects were patients 12-17 years old who were scheduled to undergo surgery and general anesthesia. Pain was assessed by a single-blinded observer present in the operating room. The major statistical method used in the analysis was multiple logistic regression. RESULTS: Among the 164 children analyzed, 96 patients (58.5%) were male. The average age was 14.3 (sd = 1.65). The incidence of pain in the control group was 32.1% (26/81), compared to 25.3% (21/83) in the treatment group. The logistic regression analysis showed that there was not sufficient evidence that the treatment group was better than control group in reducing pain (P = 0.24). There were no significant differences in postoperative recovery time, nausea, vomiting, or blood pressure between the two groups (all P values >0.10). CONCLUSION: There was not sufficient evidence to show that a 3 : 1 mixture of propofol and thiopental was better than an 11 : 1 volume admixture of propofol and lidocaine in reducing the incidence of pain on injection to 20%.

Critical care of the pediatric hematopoietic stem cell recipient in 2005.

Among the most challenging patients cared for in critical care medicine are the recipients of hematopoietic stem cell transplantation (HSCT). HSCT is now widely used as a definitive therapy for the treatment of pediatric malignancies and inborn errors of metabolism. Critical care services are required for treatment of complications of HSCT. Formerly thought to have an essentially futile prognosis, outcomes from critical care of HSCT patients have demonstrated steady improvement in many areas during the past two decades. Improvements in the management of respiratory failure, sepsis, and multiple organ system failure have resulted from improvement in oncology and critical care practices. Herein, we review the methods available for outcomes prediction, recent advances in critical care of HSCT patients, and possible directions for future investigation.

End-tidal carbon dioxide monitoring in pediatric emergencies.

End-tidal carbon dioxide (CO2) monitoring is useful in the prehospital setting, emergency department, intensive care unit, and operating room. Capnography provides valuable, timely information about the function of both the cardiovascular and respiratory systems. End-tidal CO2 monitoring is the single most useful method in confirming endotracheal tube position. It also provides information about dead space, cardiac output, and airway resistance. A thorough understanding of cardiopulmonary physiology and the technical nuances of capnometry is required for its optimal use in children. This review examines the basic physiology pertinent to end-tidal CO2 monitoring, its clinical applications, and evidence supporting its use in infants and children.