RESUMO
UNLABELLED: For the last thirty years immunotherapy has become an integral part of treatment of some cancers. The most effective approach in this context would be the use of complex immunostimulatory factors including tumor antigen in different forms, interleukins that stimulate differentiation. BACKGROUND: The aim of the study was to compare cellular immune response on specific and combined immunotherapy in patients with cervical cancer. PATIENTS AND METHODS: 76 cervical cancer patients undergoing combined radiotherapy were included into the study. Plus to basic radiation treatment two types of immunotherapy was performed: first--autolymphocytes reinfusion after in vitro incubation with tumor antigen (tumor tissue homogenate) and interleukin-2, second--combination of above mentioned immunotherapy, interleukin-2 and systemic enzyme. RESULTS: This has resulted in increase of cellular immunity parameters in the main group with combined immunotherapy an excess of cells with killer activity to ensure an effective antitumor immune response and, accordingly, the clinical efficacy of specific methods and adoptive immunotherapy in patients with cervical cancer. CONCLUSION: Immunotherapy usage in the form of a preparation of interleukin-2 and a system enzymotherapy in a combination with a specific immunotherapy is possible. This way of treatment is recommended in cases of decreasing of cellular immunity indicators.
Assuntos
Antígenos de Neoplasias , Dessensibilização Imunológica/métodos , Terapia Enzimática/métodos , Interleucina-2 , Neoplasias do Colo do Útero , Adulto , Idoso , Antígenos de Neoplasias/imunologia , Antígenos de Neoplasias/uso terapêutico , Protocolos Antineoplásicos , Feminino , Humanos , Imunidade Celular/imunologia , Interleucina-2/imunologia , Interleucina-2/uso terapêutico , Monitorização Imunológica/métodos , Estadiamento de Neoplasias , Resultado do Tratamento , Neoplasias do Colo do Útero/imunologia , Neoplasias do Colo do Útero/patologia , Neoplasias do Colo do Útero/terapiaRESUMO
Ninety-three patients with acute myocardial infarction were examined. They were divided into 2 groups: 1) those with early postmyocardial infarction angina pectoris and 2) those without it. The autonomic nervous system was studied by exploring its segmental and suprasegmental regions. The autonomic tone was evaluated by variance intervalometry. The test of human lymphocytic rosette formation and bovine red blood cells sensitized with glutaric aldehyde and loaded epinephrine was applied to estimate the adrenoception. The sympathetic tone and tissue adrenoceptor density were found to be higher in patients with early postinfarction angina than in those without it. The finding may be useful in predicting early postinfarction angina in patients with acute myocardial infarction.
