[The procedure for the wide use of praziquantel in a complex of measures to control opisthorchiasis. 2. The tolerance and efficacy of Russian-made azinox in mass treatment in foci]. / Taktika shirokogo primeneniia prazikvantelia v komplekse mer bor'by s opistorkhozom. Soobshchenie 2. Perenosimost' i éffektivnost' azinoksa otechestvennogo proizvodstva pri massovom lechenii v ochagakh.

Whether the Russian praziquantel analog azinox can be widely used in the foci of opisthorchiasis was first assessed. The outpatient treatment of 7405 patients with the agent in doses of 30, 40, 60 mg/kg body weight revealed that azinox tolerance did not depend upon the intensity and degree of clinical infection signs but it was slightly worse when a dose of 60 mg/kg was given. Children virtually showed no adverse reactions, in adults their frequency was no more than 52 +/- 1.4%. The parasitological efficiency of azinox in the used doses was 96-99% in children and 82-86% in adults. There was a clinical improvement in 65% of the treated. Thus, the national drug azinox is not inferior to the imported agent bilthricide in tolerance, parasitological and clinical efficiency. Bearing in mind the equal efficiency, but the better tolerance and less cost of the drug doses of 30 and 40 mg/kg body weight, it is advisable to use them in the foci for outpatient treatment.

[The morphofunctional properties of the blood cells and iron metabolism in the native inhabitants of the Taimyr Autonomous Okrug]. / Morfofunktsional'nye svoistva kletok krovi i obmen zheleza u zhitelei Taimyrskogo avtonommogo okruga.

The peripheral blood was studied in Dolgans, Nganasans and Nenetses, the native population living in Taimyr peninsula. The composition of their blood is really different from the European norm. In Aboriginals of Taimyr the activity of erythropoietin in blood plasma, the concentration of reticulocytes, the circulation in peripheral bed of diskocytes with one and many diverticula, the content of fetal hemoglobin are raised more than two times. The prevalence of iron deficiency anemia among the native population of Taimyr Autonomous Area is larger, than in Russia and in Aboriginals living in Evenkia and Yakutia.