[Effect of inhalation of surface-active substances on the surfactant system of the lung]. / Vplyv ingaliatsii poverkhnevo-aktyvnykh rechovyn na stan surfaktantnoi systemy legen.

Surface activity, biochemical composition and morphology of the rat lungs were studied in norm, under effect of acute hypoxia and after infusion of obsidan (1 mg/100g). The data permit suggesting that under the influence of obsidan and hypoxia a stability index of surfactants and quantity of phospholipids decreased, while the quantity of lysophosphatidylcholine and lysophosphatidylethanolamine increased. Morphology studies show that after hypoxia and obsidan infusion oedema and cell destruction developed in the lung. The inhalation of exogenous surfactant increased stability index and quantity of phospholipids, decreased the quantity of lysophospholipids but did not eliminate morphological disorders in the lung induced by hypoxia and obsidan infusion.

[Possibility of directed changes in the surface activity of rat pulmonary surfactants by means of exposure to antibodies specific to them]. / Vozmozhnost' napravlennykh izmenenii poverkhnostnoi aktivnosti surfaktantov legkogo krys putem vozdeistviia spetsificheskimi k nim antitelami.

The experiments were performed on Wistar rats with weight of 150-200 g. Antibodies were prepared by immunization of rabbits with pure surfactants of rat lungs and were intravenously injected into rats three times within 3 days intervals. These antibodies were shown to influence the superficial activity of lung surfactants and the alveolar lung cells activity. The low doses of antibodies (0.06 micrograms of protein per 100 g of body mass) stimulated the superficial activity of lung surfactants, while higher doses (3 mg of protein per 100 g of body mass) inhibited it.

[Respiratory moisture loss and possible pathways of its regulation]. / Respiratornaia vlagopoteria i vozmozhnye puti ee reguliatsii.

Examination of healthy men and those suffering from nonspecific pulmonary diseases has shown that respiratory moisture loss is induced by situation and While "lifting" examinees in the altitude chamber 5000 m upwards intensity of the moisture loss increases to 158%. Essential individual variations of the response are shown. Pulmonary diseases (chronic bronchitis, pneumonia, lecithin synthesis disturbances) make the moisture loss higher. It is concluded that lung surfactants participate in regulation of the respiratory moisture loss. participate in regulation of the respiratory moisture loss.

[The effect of alpha-tocopherol on pulmonary surfactants]. / Vliianie alpha-tokoferola na surfaktanty legkogo.

Tocopherol deficiency in the rat organism stimulates activation of lipid peroxidation: the content of hydroperoxides in blood and surfactants of lungs tends to increase, the superweak glow of surfactant lipids enhances. In this case the surface activity of lung surfactants is lower than in the control. It also gets lower in hypervitaminosis rats. The data obtained may be used for development of approaches to the tocopherol (antioxidant) correlation of the lung surfactant system functioning.

[Functional role of pulmonary surface-active substances]. / K voprosu o funktsional'noi roli poverkhnostno-aktivnykh veshchestv legkogo.

Freshly prepared from the rat lung solution of the surfactant active substances (SA1) accelerated oxygen absorption at the borderline of the phases. The oxidized SA1 solutions produced an inhibitory effect. As suggested, functional role of SA1 in the realization of external respiration is not limited to reduction of surface tension and alveoli stabilization, but also includes participation in oxygen absorption and its transport regulation through the aerohematic barrier.