[Biochemical changes of red blood cells in children with cerebral palsy and other organic brain disorders].

One hundred and twenty-five children with cerebral palsy (n = 108) and organic CNS lesions (n = 17) have been studied. A control group included 30 children without any neurological lesions. Lipids and phospholipids spectra, Ca, Mg- and Na, K-ATPases, intensity of red blood cells lipid peroxidation and erythrocyte free magnesium content have been determined. Children with cerebral palsy had a higher percentage of cholesterol ethers and final products of lipid peroxidation in red blood cells--Shiff bases and a decrease of intraerythrocytic free magnesium. Patients with atonic-astatic syndrome were characterized by a sharp increase of Na, K-ATPase activity accompanied by increased content of such phospholipids as cardiolipin and phosphatide acid as well as Shiff bases. In patients with organic CNS lesions, Shiff bases content was similar to that in the control group, intracellular magnesium also did not differ significantly from the controls, but cardiolipin, phosphatide acid, cholesterol ethers and triglycerol concentrations were reduced. All the patients with neurological disorders had an increased percentage of phosphatidilcholin in red blood cells.

[The effect of a low-frequency magnetic field on erythrocyte membrane function and on the prostanoid level in the blood plasma of children with parasystolic arrhythmia]. / Vliianie nizkochastotnogo magnitnogo polia na sostoianie membran éritrotsitov i soderzhanie prostanoidov v plazme krovi detei s parasistolicheskoi aritmiei.

As shown by clinical and biochemical evidence on 23 parasystolic children, the treatment with low-frequency magnetic field improves humoral and cellular processes participating in cardiac rhythm regulation. There is activation of Ca, Mg-ATPase in the red cells, a reduction of plasma thromboxane levels. Red cell phospholipid composition insignificantly change. Further courses of magnetotherapy may lower the risk of recurrent arrhythmia.

[Disorders of membrane mechanisms for regulating calcium homeostasis in cardiac arrhythmias in children]. / Narushennia membrannykh mekhanizmov reguliatsii kal'tsievogo gomeostaza pri aritmiiakh serdtsa u detei.

Importance of calmodulin and Ca2+ in membranes of erythrocytes and myocardium was studied in children with ectopic forms of cardiac arrhythmia--extrasystole, paroxysmal and nonparoxysmal tachycardia. Activation of lipid peroxidation and shifts in cytomembrane phospholipid spectrum were shown to be involved in impairments of calcium homeostasis regulation, which is responsible for control of electromechanical parameters and may be related to deterioration of myocardial electrophysiological properties.

[Use of vitamins in allergic illnesses in children]. / Primenenie vitaminov pri allergicheskikh zabolevaniiakh u detei.

Therapeutic efficacy of vitamins B6, P and E was studied in children with allergic diseases. Bronchial asthma and atopic dermatitis were treated more effectively if maximal doses of vitamin B6 were used. Quercetin was found to be useful for treatment of children with pollinosis in order to correct impairments in metabolism of lymphocyte membrane lipids. Only slight efficacy of vitamin E was detected in atopic dermatitis of children.

[The absorption function of the small intestine and the effect on it of diet therapy in food allergy in children]. / Absorbtsionnaia funktsiia tonkoi kishki i vliianie na nee dietoterapii pri pishchevoi allergi u detei.

Small intestine absorption function was studied in 46 children with food allergy basing on the results of D-xylose test and estimating protein absorption by blood serum ovalbumin assay in circulating immune complexes. Decreased carbohydrate and increased protein absorption was recorded in the small intestine of the patients and the normalizing effect of the elimination diet on these changes was shown.

[Various indices of collagen metabolism in children with rheumatoid arthritis]. / Nekotorye pokazateli obmena kollagena u detei, bol'nykh revmatoidnym artritom.

To study collagen metabolism, 113 children aged 3 to 14 years afflicted with rheumatoid arthritis and 43 conventionally normal children were examined. The patients were examined for free and protein-bound hydroxyproline in the blood serum and synovial fluid and for total hydroxyproline in diurnal urine. The blood serum and synovial fluid showed a decline of free and a rise of protein-bound hydroxyproline, more marked in severe rheumatoid arthritis, its higher activity and damage to numerous joints. Excretion of free and total hydroxyproline with urine was significantly lower than in the normal children whatever the form of rheumatoid arthritis, its activity or number of the joints involved into the process. In view of the lack of hydroxyprolinuria in the sick children, the authors discuss a hypothesis of a potential initial decrease of collagen formation in children afflicted with rheumatoid arthritis, suggesting its relationship to the "ligand pathology".

[Parameters of cellular adaptation in newborn infants in health and in perinatal injuries of the CNS]. / Pokazateli kletochnoi adaptatsii u novorozhdennykh v norme i pri perinatal'nykh povrezhdeniiakh TsNS.

A study was made of the level of compensatory and adaptive reactions in red blood cells (intensity of membranous metabolism, lipid peroxidation, malonic dialdehyde (MDA) metabolism, changes in the correlation of lipid fractions) in the newborn in health and in perinatal CNS injuries within the first days of life. Changes in the indicated parameters were examined after preincubation of red blood cells under physiologic conditions and by means of MDA addition to the incubation medium. It is concluded that the newborn with perinatal CNS injuries are marked by metabolic inertness and reduced cellular adaptation in red blood cells preincubated under physiologic conditions as well as by pronounced disadaptation under the conditions of excess MDA.