RESUMO
The process of lipid peroxidation (LPO) and the effects of alpha-tocopherol were studied in the liver and blood serum of albino male rats under acute immobilization stress. The results of the research show tissue and age specific responses of LPO in the intact and stressed animals. Pretreatment of animals with alpha-tocopherol decreased accumulation of LPO products especially in the liver.
Assuntos
Envelhecimento/metabolismo , Antioxidantes/farmacologia , Peroxidação de Lipídeos/efeitos dos fármacos , Lipídeos/sangue , Fígado/efeitos dos fármacos , Estresse Psicológico/metabolismo , alfa-Tocoferol/farmacologia , Animais , Fígado/metabolismo , Masculino , Ratos , Ratos WistarRESUMO
Research of influence of stress immobilization on relative mass of reproductive and immunocompetent organs of young and old rats was carried out. The study of age features of correction by alpha-tocopherol of the peroxidation lipid (POL) stress deviations was realized. Specific answer of researched organs and age differences for stress effects was revealed. Tissue and age differences between a physiological level of POL at intact rats, and its change at stress animals fixed. Suppression of POL processes intensity against a background preliminary vitamin E injection and its combination with extreme effects specifies its protective action especially expressed in a liver. Results of researches show the large stress-resistance at young animals and the expressed damaging action of an stress at old animals.