1.
Bioorg Med Chem Lett
; 12(13): 1763-6, 2002 Jul 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12067556
RESUMO
A preliminary account on the structure-based design, synthesis and evaluation of peptidomimetic inhibitors of HIV-1 protease containing beta-D-mannopyranoside scaffolds is given. The compounds prepared had IC(50) values in the micromolar range. The results provide a platform for the development of more potent carbohydrate-based inhibitors of HIV-1 and other aspartic proteases.