MORTALITY RISK ASSESSMENT AMONG PATIENTS, HOSPITALIZED FOR COVID-19.

In Georgia, the number of confirmed cases of Coronavirus were 1,85,5289. Among them, 17 132 patients died. Information on risk factors for mortality is insufficient. The purpose of our research is to evaluate clinical features of heavy patients with severe COVID and determine prognostic factors of outcome. Factors associated with critical COVID-19 included older age and certain chronic medical conditions. The clinical material of 250 chronically ill COVID-19 patients admitted to the intensive care unit was retrospectively studied. We divided the patients into two groups. The dead and the survivors. Demographic data, comorbidities, chronic diseases, results of ultrasound, cardiography, computed tomography and laboratory characteristics were studied. In patients with chronic diseases, in the intensive care unit during COVID-19, the relative chance of survival decreases: CRP3 - OR=0.98(95% CI:0.97-0.99Hydrothorax- OR=0.24(95% CI:0.06-0.95); Sepsis/Septic shock - OR=0.07(95% CI:0.01-0.39); WBC - OR=0.86(95% CI:0.74-0.99); Mechanical lung ventilation - OR=0.01(95% CI:0.00-0.05)); increase survival relative chance- pO2 - OR=1.03(95% CI:1.0-1.06). Predictors of mortality in patients with chronic diseases: coagulation characteristics, inflammatory markers, sepsis, and artificial lung ventilation. Risk factors for covid-19 mortality need to be studied to increase pandemic preparedness.

CHANGES IN SPERMATOGENESIS AFTER SIMULATED INGUINAL HERNIA REPAIR IN EXPERIMENT.

The Lichtenstein method revolutionized the treatment of inguinal hernias. But this method is accompanied by serious complications, as evidenced by the publications of recent years. Such complications include the development of fibrous changes in the scrotum, deejaculation, obstructive azoospermia, oligospermia. Therefore, in the treatment of inguinal hernia, the so-called isolation methods are becoming more and more relevant, which implies complete isolation from the rope mesh and does not affect spermatogenesis. Aim of the study - to compare the morphological parameters of sperm before and after hernia surgery in the groups that underwent modeled herniaplasty by Lichtenstein's method and with spermatic cord isolation from a mesh by Gvenetadze. 16 male rabbits aged 12 months ± 3 months, weighing 3.5 ± 0.5 kg were included in the study. Of these, 8 (50%) underwent hernioplasty by Lichtenstein's method, and 8 (50%) - with complete isolation of Bagirak. Gvenetadze's method. Rabbits were divided into two groups. The first group: 8 rabbits, which underwent Lichtenstein's hernia surgery. The second group: 8 rabbits, which underwent hernioplasty with complete isolation of the sacrum using the Gvenetadze method. In both groups, a spermomorphocytological study was performed 2 days before the operation and 3 months and 6 months after the operation. The study included a complete spermomorphocytological examination by studying the following sperm parameters: sperm volume, color, turbidity, ejaculatory time, stickiness, odor, PH, number of spermatozoa in 1 ml, number of spermatozoa in the whole ejaculate, live spermatozoa, motile spermatozoa, progressive motile spermatozoa, Normal morphological of permatozoites Molds, leukocytes, erythrocytes, lipoid bodies, spermagglutination, fungi, bacteria, mucus. Semen were collected 2 days before surgery, 3 months after surgery, and 6 months after surgery. The sperm was obtained using the so-called "artificial vagina". Our study showed that inguinal hernia repair with spermatic cord isolation does not affect spermatogenesis.