[Effect of diuretics on lithium chloride toxicity]. / Vliianie diuretikov na toksichnost' khlorida litiia.

Experiments on guinea-pigs, albino rats and mice have shown that administration of novurint, cyclomethiatiazid, hypothiazid, diacarb and lasix provides no favourable results in acute poisoning with LD50 and LD90 of lithium chloride. Euphylline is effective only after administration of LD50 of lithium chloride.

[Pathogenesis of lithium polyuria]. / O pathogeneze litievoi poliurii

An attempt is made to elucidate the pathogenesis of polyuria arising consequent upon medication of affective states with lithium salts. Experiments conducted with 54 male-rats showed that changes in the neurosecretion of supraoptic nuclei of the hypothalamus and neurohypophysis that take place after a course-wise intraperitoneal administration in amounts of 200 mg/kg (2/9DL20) of lithium chloride per 24 hours for a duration of 6 days occur parallel with histochemical changes of renal acid muconpolysaccharides and they accord with the nature of diuresis disorders. By the 5th day of the experiment the compound perverts the antidiuretic effect of a single subcutaneous injection of pituitrin (10 U/kg). The authors infer therefrom that polyuria emerging after introduction of lithium salts is caused by a deranged synthesis and secretion of the diuretic hormone and also by the ability of lithium to mitigate the action of this hormone on the kidneys.

[Role of the kidneys in the pathogenesis of lithium poisoning]. / O roli pochek v patogeneze litievoi intoksikatsii

Lithium intoxication was induced in rats by intraperitoneal administration of lithium chloride in a daily dose of 200 mg/kg (0.22 LD50) for 6 days. Polyuria connected with pathological changes in the epithelium of the convoluted tubules and depression of the antidiuretic hormone--acid mucopolysaccharides system in the area of the straight kidney tubules was observed on the 6th day of the experiments. Oligouria and death of some of the animals on the 7th experimental day was caused by severe lesions the kidney structure. Further observation (30 days) demonstrated that, along with the regeneration processes, there developed a marked sclerosing ofthe kidney tissue. A conclusion was drawn that severe lithium intoxication was associated with the development of acute renal insufficiency. Functional reserves of the kidneys after the cessation of lithium chloride administration remained lowered for a long period.

[Effect of lithium chloride on kidney function in rats]. / Vliianie khlorida litiia na funktsiiu pochek u krys

Test staged on rats have brought evidence that lithium chloride acts damagingly on all parts of the nephron, inhibiting, first of all, the processes of filtration and then of secretion and reabsorption. Polyuria arising under the effect of lithium is caused by reduced reabsorption of water in the tubules and anuria--by depression of the glomerular filtration.

[Estrogenic effect of white head cabbage (Brassica aleraceae)]. / Ob éstrogennom deistvii belokochannoi kapusty (Brassica aleraceae)

An extract obtained from dessicated white cabbage with the help of chloroform and introduced subcutaneously or perorally to sexually immature mice in an equivalent corresponding to 5 g of the dry product for a space of 4--6 days displayed an extrogenic action. Long-term storage, souring, cooking of the cabbage result in a somewhat diminished estrogenic activity of the cabbage.