[Catecholamines and their metabolites in children with Asperger and Kanner syndromes].

Children with Asperger and Kanner syndromes in the stable state demonstrate similar decrease in plasma norepinephrine. In the aggravated state, these changes become more expressed and are characterized by a decrease in plasma tyrosine, norepinephrine, normetanephrine and by an increase in dopamine and homovanylic acid and a decrease in excretion of norepinephrine and an increase in excretion of homovanylic acid, epinephrine and MHPG. Only in children with Kanner syndrome in the aggravated state plasma MHPG increases, excretion of tyrosine decreases and excretion of normetanephrine increases. The observed imbalance in dopamine and epinephrine/norepinephrine systems justifies combined analysis of changes in catecholamines and their metabolites levels as the most informative approach in the study of the effect of autistic disorders.

[Amino acids and their metabolites in blood and urine of children with minimal cerebral dysfunction]. / Aminokisloty i ikh metabolity v krovi i moche pri minimal'noi tserebral'noi disfunktsii u detei.

The following changes were found in children in the minimal cerebral dysfunction: the hypoaminoacidemia and hypoaminoaciduria with decrease of glutamate and aspartate, their amides, methionine and serine in the blood and urine; decrease of lysine, taurine, tyrosine, catecholamines and serotonin in the blood; increase of GABA and glycine in the blood; increase of xanthurenate, proline and cysteine in the urine. The ratio excitatory/inhibitory mediatory amino acids decreased significantly. The ratio essential/nonessential amino acids and concentrations of amino acids, transporting by x-AG, beta and A/ASC systems, decrease in the blood; majority of transporting systems in the kidney functions augmently. Disturbances of amino acids metabolism disappear or decrease in successful treatment.