[Cytological classification of precancer and cancer of the cervix uteri]. / Tsitologicheskaia klassifikatsiia predraka i raka sheiki matki.

A cytological classification of dysplasia, intraepithelial and invasive cancer of the cervix uteri is suggested. Cytologic criteria for differential diagnosis are discussed. Cytologic diagnosis of precancer and cancer made on the basis of the said classification was verified in 63.5 and 97.3%, respectively.

[Clinico-morphological changes during treatment of endometrial cancer with progestins]. / Kliniko-morfologicheskie izmeneniia pri lechenii raka éndometriia progestinami.

The results of the complex clinico-morphological study of the effect of 17-a-hydroxyprogesterone-caproate are reported in 71 patients aged from 37 to 75. Stage I was noted in 17 patients, stage II--in 51, stage III--in 3. A total dosage was 5,0; 10,0; 20,0 and 30,0 for the course of treatment. Following the hormonal therapy all these patients were subjected to surgery. To study the hormonal pathomorphism specimens from the uterine cavity were assayed histologically and cytologically prior to and during the hormonal therapy, the removed specimen was examined after the operation. The clinico-morphological studies indicated that 17 GPC shows the antitumor effect in endometrial cancer, so the complete tumor regression seems to be possible. The antitumor effect is mostly pronounced at initial stages of the disease and with high-differentiated tumors. The data obtained may be used to solve the problem on the purposeful application of 17 GPC either in the complex of therapeutic measures or as a separate method of treatment.

[Morphologic criteria for the initial forms of stage Ia invasive cancer of the cervix uteri]. / Morfologicheskie kriterii nachal'nykh form invazivnogo raka sheiki matki Ia stadii.

Morphological study was carried out on biopsy and operation materials from 107 patients with initial forms of cervical cancer. The initial forms of cancer include lesions suspect for infiltrative cancer, and infiltrative cancer with the depth of invasion not more than 3 mm. The condition of the stroma in initial invasion which is considered to be a defence reaction is described in detail. In 85% of the patients the infiltrative cancer developed against the background of carcinoma in situ, in 15% against the background of dysplasia. The authors believe that the morphological features of the initial invasive forms are sufficient for distinguishing them as a separate stage Ia.

[Clinical morphological characteristics of the initial forms of cervical cancer]. / Kliniko-morfologicheskaia kharakteristika nachal'nykh form raka sheiki matki

An analysis of clinical and colposcopic findings in 107 patients with early forms of invasive cancer of the uterine cervix with deep invasion not more than 3 mm (st. 1-a) and their correlation with the results of histological assay enabled the authors to give the clinico-morphological characteristics of this stage of the lesion. It was found that 40% of patients had complaints pathognomonic for a malignant process; 91.6% of patients showed visually recognizable but nonspecific changes in the cervix; in 94% of cases colposcopy revealed cancer suspicious changes of the common and increased atypical epithelium type. In 53.3% cancer foci are so limited that these would be removed by primary biopsy. Metastases in regional lymph nodes were detected in 1.6%. Limited foci of the cancer and extremly rare metastases spread in regional lymph nodes justify the use of hysterectomy solely in treatment of such patients.