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1.
Sci Rep ; 14(1): 8190, 2024 Apr 08.
Artigo em Inglês | MEDLINE | ID: mdl-38589510

RESUMO

Climate change necessitates exploring innovative geoengineering solutions to mitigate its effects-one such solution is deploying planetary sunshade satellites at Sun-Earth Lagrange point 1 to regulate solar radiation on Earth directly. However, such long-span space structures present unique technical challenges, particularly structural scalability, on-orbit manufacturing, and in-situ resource utilization. This paper proposes a structural concept for the sunshade's foil support system and derives from that a component-level modular system for long-span fiber composite lightweight trusses using coreless filament winding. Within a laboratory-scale case study, the component scalability, as well as the manufacturing and material impacts, were experimentally investigated by bending deflection testing. Based on these experimental results, FE models of the proposed structural concept were calibrated to estimate the maximum displacement and mass of the foil support structure, while comparing the influences of foil edge length, orbital load case, and material selection.

2.
Materials (Basel) ; 16(23)2023 Nov 27.
Artigo em Inglês | MEDLINE | ID: mdl-38068121

RESUMO

Polymer concrete has proved to be advantageous in machine building for many years thanks to its excellent damping properties. Until now, its use was limited to machine beds due to its comparatively low tensile strength. Its use in moving structural components has not been possible until now. Recent research results have shown that this challenge can be met by integrating prestressed carbon fibers. Until now, the production of samples out of prestressed fiber-reinforced polymer concrete has been carried out according to fixed specifications. It is not yet clear whether these specifications are suitable to fully exploit the potential of the material. Samples manufactured to these specifications show at least a large scatter in bending stiffness. Within the scope of this paper, the existing manufacturing process is validated by the variation of process steps. Specifically, this involved the use of a shaker, variation of the dwell time in the mold, variation of the resin content, and the procedure for impregnating the fibers. The characterization of the samples showed that the scatter could only be reduced by increasing the dwell time. However, this leads to a decrease in bending stiffness and, thus, is not suitable for further improvement of the novel material.

3.
Materials (Basel) ; 16(13)2023 Jul 06.
Artigo em Inglês | MEDLINE | ID: mdl-37445164

RESUMO

Natural fibers do not have a long life in soil; therefore, they cannot replace synthetic textiles in many applications. However, in order to solve ever-increasing global environmental problems due to microplastics, more and more natural polymers must be used, creating a need for research into the sustainable life extension of natural fibers. Lignin is, along with cellulose, a main component of wood, and is produced in large quantities as waste during paper production. With appropriate processing, lignin can be exploited/used as a textile auxiliary to combine the strength-enhancing properties of textiles made from natural fibers with the protective properties of a lignin coating. However, there is not yet sufficient research on how to integrate lignin into textile applications. For this purpose, in this study, we have investigated whether thermoplastic lignin can be processed as a surface protective coating. We tested lignin as a yarn coating to extend the service life of cellulosic textiles. Cotton yarns have been coated with lignin in variations of coating mass, characterized and investigated by means of soil burial tests. As the soil burial tests conducted in climate chamber and outdoor field environments showed, the lifespan of textiles made from natural fibers can be significantly extended with a lignin coating. Long-term resilience has been demonstrated in standard burial tests. In the outdoor tests, the lignin coating was still fully intact, even after about 160 days of burial. The textile materials coated in this way enable sustainable applications, especially for geotextiles. They have an adjustable, sufficiently long service life; however, they are still biodegradable, and can therefore replace some applications, such as vegetating trench/brook slopes, with synthetic materials. Lignin-coated textiles have the potential to significantly reduce the carbon footprint, reduce not only the dependence on petroleum-based products but also the amount of microplastics entering the environment. Further research can be conducted to improve lignin compounding in terms of other interesting properties for specific textile applications. Process optimization could increase the protective effect and further extend the life of useful textiles in soil.

4.
Materials (Basel) ; 16(5)2023 Feb 28.
Artigo em Inglês | MEDLINE | ID: mdl-36903129

RESUMO

Mass transport in textiles is crucial. Knowledge of effective mass transport properties of textiles can be used to improve processes and applications where textiles are used. Mass transfer in knitted and woven fabrics strongly depends on the yarn used. In particular, the permeability and effective diffusion coefficient of yarns are of interest. Correlations are often used to estimate the mass transfer properties of yarns. These correlations commonly assume an ordered distribution, but here we demonstrate that an ordered distribution leads to an overestimation of mass transfer properties. We therefore address the impact of random ordering on the effective diffusivity and permeability of yarns and show that it is important to account for the random arrangement of fibers in order to predict mass transfer. To do this, Representative Volume Elements are randomly generated to represent the structure of yarns made from continuous filaments of synthetic materials. Furthermore, parallel, randomly arranged fibers with a circular cross-section are assumed. By solving the so-called cell problems on the Representative Volume Elements, transport coefficients can be calculated for given porosities. These transport coefficients, which are based on a digital reconstruction of the yarn and asymptotic homogenization, are then used to derive an improved correlation for the effective diffusivity and permeability as a function of porosity and fiber diameter. At porosities below 0.7, the predicted transport is significantly lower under the assumption of random ordering. The approach is not limited to circular fibers and may be extended to arbitrary fiber geometries.

5.
Polymers (Basel) ; 14(19)2022 Sep 27.
Artigo em Inglês | MEDLINE | ID: mdl-36236008

RESUMO

The present experimental work analyses the potential of lignin as a matrix for materials made from renewable resources for composite components and the production of hybrid semi-finished products by coating a flax fibre yarn. Natural fibres, due to their low density, in combination with lignin can be a new renewable source for lightweight products. For this purpose, the extrusion process was adapted to lignin as a matrix material for bio-based composites and coating of natural fibre yarns. A commercial flax yarn is the basis for the lignin coating by extrusion. Subsequently, the coated flax yarn was characterised with regard to selected yarn properties. In order to produce composite plates, the lignin-coated flax yarn was used as warp yarn in a bidirectional fabric due to its insufficient flexibility transversely to the yarn axis. The commercial flax yarn was used as weft yarn to increase the fibre volume content. The tensile and flexural properties of the bio-based composite material were determined. There was a significant difference in the mechanical properties between the warp and weft directions. The results show that lignin can be used as matrix material for bio-based natural fibre composites and the coating of natural fibre yarns is an alternative to spun hybrid yarns.

6.
Materials (Basel) ; 15(9)2022 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-35591593

RESUMO

Coreless filament winding is an emerging fabrication technology in the field of building construction with the potential to significantly decrease construction material consumption, while being fully automatable. Therefore, this technology could offer a solution to the increasing worldwide demand for building floor space in the next decades by optimizing and reducing the material usage. Current research focuses mainly on the design and engineering aspects while using carbon and glass fibers with epoxy resin; however, in order to move towards more sustainable structures, other fiber and resin material systems should also be assessed. This study integrates a selection of potential alternative fibers into the coreless filament winding process by adapting the fabrication equipment and process. A bio-based epoxy resin was introduced and compared to a conventional petroleum-based one. Generic coreless wound components were created for evaluating the fabrication suitability of selected alternative fibers. Four-point bending tests were performed for assessing the structural performance in relation to the sustainability of twelve alternative fibers and two resins. In this study, embodied energy and global warming potential from the literature were used as life-cycle assessment indexes to compare the material systems. Among the investigated fibers, flax showed the highest potential while bio-based resins are advisable at low fiber volume ratios.

7.
Polymers (Basel) ; 14(4)2022 Feb 11.
Artigo em Inglês | MEDLINE | ID: mdl-35215611

RESUMO

Increasing resource consumption and a growing amount of textile waste increase the importance of a circular economy and recycling in the fashion and apparel industry. Environmentally friendly bio-based composites made from cellulosic fibres obtained from textile waste, and polymers based on renewable raw materials present a possible solution. In this study, the development of textile semi-finished products based on medium-to-long cotton and flax fibres obtained from textile waste in combination with a bio-based thermoplastic matrix for lightweight applications is investigated. For the production of natural fibre-polylactide hybrid yarns, fibre slivers with improved fibre orientation and blending are produced. Subsequently, quasi-unidirectional woven fabrics are produced and consolidated into bio-based composites. Textile and mechanical properties of hybrid yarns as well as bio-composites are analysed with regard to the influence of fibre length, fibre distribution in the yarn, yarn structure and fibre volume content. The results show that the production of bio-based semi-finished products can be a potential way for upcycling textile waste.

8.
3D Print Addit Manuf ; 9(3): 145-160, 2022 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-36655206

RESUMO

Digitization and automation are essential tools to increase productivity and close significant added-value deficits in the building industry. Additive manufacturing (AM) is a process that promises to impact all aspects of building construction profoundly. Of special interest in AM is an in-depth understanding of material systems based on their isotropic or anisotropic properties. The presented research focuses on fiber-reinforced polymers, with anisotropic mechanical properties ideally suited for AM applications that include tailored structural reinforcement. This article presents a cyber-physical manufacturing process that enhances existing robotic coreless Filament Winding (FW) methods for glass and carbon fiber-reinforced polymers. Our main contribution is the complete characterization of a feedback-based, sensor-informed application for process monitoring and fabrication data acquisition and analysis. The proposed AM method is verified through the fabrication of a large-scale demonstrator. The main finding is that implementing AM in construction through cyber-physical robotic coreless FW leads to more autonomous prefabrication processes and unlocks upscaling potential. Overall, we conclude that material-system-aware communication and control are essential for the efficient automation and design of fiber-reinforced polymers in future construction.

9.
Materials (Basel) ; 14(19)2021 Sep 23.
Artigo em Inglês | MEDLINE | ID: mdl-34639903

RESUMO

A hemispherical research demonstration pavilion was presented to the public from April to October 2019. It was the first large-scale lightweight dome with a supporting roof structure primarily made of carbon- and glass-fiber-reinforced composites, fabricated by robotic coreless filament winding. We conducted monitoring to ascertain the sturdiness of the fiber composite material of the supporting structure over the course of 130 days. This paper presents the methods and results of on-site monitoring as well as laboratory inspections. The thermal behavior of the pavilion was characterized, the color change of the matrix was quantified, and the inner composition of the coreless wound structures was investigated. This validated the structural design and revealed that the surface temperatures of the carbon fibers do not exceed the guideline values of flat, black façades and that UV absorbers need to be improved for such applications.

10.
Materials (Basel) ; 14(19)2021 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-34640132

RESUMO

The connection between flexible textiles and stiff electronic components has always been structurally weak and a limiting factor in the establishment of smart textiles in our everyday life. This paper focuses on the formation of reliable connections between conductive textiles and conventional litz wires using ultrasonic welding. The paper offers a promising approach to solving this problem. The electrical and mechanical performance of the samples were investigated after 15 and 30 wash-and-dry cycles in a laundry machine. Here the contact resistances and their peeling strength were measured. Furthermore, their connection properties were analysed in microsections. The resistance of the joints increased more than 300%, because the silver-coated wires suffered under the laundry cycles. Meanwhile, the mechanical strength during the peeling test decreased by only about 20% after 15 cycles and remained the same after 30 cycles. The good results obtained in this study suggest that ultrasonic welding offers a useful approach to the connection of textile electronics to conductive wires and to the manufacture of smart textiles.

11.
Biomimetics (Basel) ; 6(3)2021 Jun 22.
Artigo em Inglês | MEDLINE | ID: mdl-34206619

RESUMO

This paper aims to define the influencing design criteria for compliant folding mechanisms with pneumatically actuated hinges consisting of fiber-reinforced plastic (FRP). Through simulation and physical testing, the influence of stiffness, hinge width as well as variation of the stiffness, in the flaps without changing the stiffness in the hinge zone, was evaluated. Within a finite element model software, a workflow was developed for simulations, in order to infer mathematical models for the prediction of mechanical properties and the deformation behavior as a function of the aforementioned parameters. In conclusion, the bending angle increases with decreasing material stiffness and with increasing hinge width, while it is not affected by the flap stiffness itself. The defined workflow builds a basis for the development of a predictive model for the deformation behavior of FRPs.

12.
Sensors (Basel) ; 21(2)2021 Jan 14.
Artigo em Inglês | MEDLINE | ID: mdl-33466632

RESUMO

A suitable connection method to automatically produce E-textiles does not exist. Ultrasonic soldering could be a good solution for that since it works with flux-free solder, which avoids embrittlement of the textile integrated wires. This article describes the detailed process of robot-assisted ultrasonic soldering of e-textiles to printed circuit boards (PCB). The aim is to understand the influencing factors affecting the connection and to determine the corresponding solder parameters. Various test methods are used to evaluate the samples, such as direct optical observation of the microstructure, a peeling tensile test, and a contact resistance measurement. The contact strength increases by reducing the operating temperature and the ultrasonic time. The lower operating temperature and the reduced ultrasonic time cause a more homogeneous metal structure with less defects improving the mechanical strength of the samples.

13.
Math Biosci ; 327: 108432, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32710903

RESUMO

The benefits of optimization-based modeling for parameter estimation of Hill-type muscle models are demonstrated. Therefore, we examined the model and data of Günther et al. (2007), who analyzed isometric, concentric, and quick-release contractions of a piglet calf muscle. We found that the isometric experiments are suitable for derivative-based parameter estimation while the others did not provide any additional value. During the estimation process, certain parameters had to be fixed. We give possible reasons and provide impulses for modelers. Subsequently, unnecessarily complex or deprecated model parts were exchanged and the new model was fitted to the data. In order to be able to provide a reliable estimation of the whole parameter set, we propose two isometric and two quick-release experiments, which are real-life feasible and together allow an identification of all parameters based on a local sensitivity analysis. These experiments can be used as qualitative guidelines for practitioners to reduce the experimental effort when estimating parameters for macroscopic muscle models.


Assuntos
Modelos Biológicos , Contração Muscular/fisiologia , Músculo Esquelético/fisiologia , Animais , Simulação por Computador , Humanos , Contração Isométrica/fisiologia , Conceitos Matemáticos , Suínos
14.
Materials (Basel) ; 13(11)2020 May 26.
Artigo em Inglês | MEDLINE | ID: mdl-32466368

RESUMO

Experts attest the smart textiles market will have high growth potential during the next ten years. Laser soldering is considered to be a good contacting method because it is a contactless process. For this reason, it is intended to investigate the contacting process of printed circuit boards (PCB) to isolated conductive textile strips by means of a ytterbium­doped fiber laser (1064 nm). During the investigation, the copper strands in the textile tape were stripped by the laser and soldered to the PCB without any transport of the textile. Therefore, we investigated different sets of parameters by means of a design of experiment (DoE) for different types of solder pastes. Finally, the joinings were electrically analyzed using a contact resistance test, optically with a REM examination, and mechanically using a peeling test.

15.
J Biomed Mater Res B Appl Biomater ; 108(3): 809-818, 2020 04.
Artigo em Inglês | MEDLINE | ID: mdl-31225700

RESUMO

Since loss of meniscus is correlated with an increasing risk for osteoarthritis, meniscal scaffolds are proposed as new strategies. Development of a suitable scaffold has to take into account differing meniscus thickness, exposure to compressive and tensile forces combined with high porosity and biocompatibility of the material. After physical testing of three flat scaffolds composed of different modified polyglycolic acid (PGA) fibers, a three-dimensional meniscus-shaped PGA-hyaluronan implant was generated. Micro-computed tomography showed 90% porosity in the outer area with 50% in the inner area of the implant. Biocompatibility and expression of meniscus typical cartilaginous genes were shown for human meniscus cells cultivated in the implant with 10% human serum or 5% platelet-rich plasma for 14 days in vitro. The proof-of-concept study in sheep demonstrated proteoglycan- and collagen type I-rich repair tissue formation in partial meniscectomy combined with a meniscus-shaped PGA-hyaluronan implant after 6 months. In contrast, the control showed nearly no repair tissue formation. Thus, meniscus-shaped PGA-hyaluronan implants might be a suitable therapeutic approach to support repair tissue formation in partial meniscectomy.


Assuntos
Artroplastia do Joelho/métodos , Materiais Biocompatíveis/química , Menisco/transplante , Ácido Poliglicólico/química , Alicerces Teciduais/química , Idoso , Animais , Materiais Biocompatíveis/metabolismo , Técnicas de Cultura de Células , Feminino , Regulação da Expressão Gênica , Humanos , Ácido Hialurônico/química , Ácido Hialurônico/metabolismo , Masculino , Testes Mecânicos , Menisco/citologia , Regeneração , Ovinos , Fatores de Tempo , Engenharia Tecidual , Cicatrização
16.
Sensors (Basel) ; 20(1)2019 Dec 18.
Artigo em Inglês | MEDLINE | ID: mdl-31861274

RESUMO

Despite all the growth forecasts of the smart textiles market, there is no stable automated manufacturing process for attaching classic electronics to textiles. The great amount of manual production steps causes high prices, which slow down market growth. During the production process, the contacting step offers the greatest potential to reduce manual manufacturing steps. For this reason, we have analyzed various contacting methods for electronic parts on conductive yarns that have a high potential for automation. The chosen methods were thermode soldering, insulation-displacement connectors and anisotropic conductive adhesives. In order to ensure reliable mechanical contacting, the samples were tested in a peeling experiment. The examination of the contact resistances took place in the context of a resistance test using four-wire measuring technology.

17.
Med Phys ; 46(5): 2025-2030, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30748029

RESUMO

PURPOSE: High dose rate brachytherapy applies intense and destructive radiation. A treatment plan defines radiation source dwell positions to avoid irradiating healthy tissue. The study discusses methods to quantify any positional changes of source locations along the various treatment sessions. METHODS: Electromagnetic tracking (EMT) localizes the radiation source during the treatment sessions. But in each session the relative position of the patient relative to the filed generator is changed. Hence, the measured dwell point sets need to be registered onto each other to render them comparable. Two point set registration techniques are compared: a probabilistic method called coherent point drift (CPD) and a multidimensional scaling (MDS) technique. RESULTS: Both enable using EMT without external registration and achieve very similar results with respect to dwell position determination of the radiation source. Still MDS achieves smaller grand average deviations (CPD-rPSR: MD = 2.55 mm, MDS-PSR: MD = 2.15 mm) between subsequent dwell position determinations, which also show less variance (CPD-rPSR: IQR = 4 mm, MDS-PSR: IQR = 3 mm). Furthermore, MDS is not based on approximations and does not need an iterative procedure to track sensor positions inside the implanted catheters. CONCLUSION: Although both methods achieve similar results, MDS is to be preferred over rigid CPD while nonrigid CPD is unsuitable as it does not preserve topology.


Assuntos
Braquiterapia/métodos , Neoplasias da Mama/radioterapia , Processamento de Imagem Assistida por Computador/métodos , Planejamento da Radioterapia Assistida por Computador/métodos , Braquiterapia/instrumentação , Neoplasias da Mama/patologia , Fenômenos Eletromagnéticos , Desenho de Equipamento , Feminino , Humanos , Órgãos em Risco/efeitos da radiação , Dosagem Radioterapêutica , Tomografia Computadorizada por Raios X/métodos
18.
Mol Psychiatry ; 23(4): 943-951, 2018 04.
Artigo em Inglês | MEDLINE | ID: mdl-28373685

RESUMO

The notion that schizophrenia is a neurodevelopmental disorder in which neuropathologies evolve gradually over the developmental course indicates a potential therapeutic window during which pathophysiological processes may be modified to halt disease progression or reduce its severity. Here we used a neurodevelopmental maternal immune stimulation (MIS) rat model of schizophrenia to test whether early targeted modulatory intervention would affect schizophrenia's neurodevelopmental course. We applied deep brain stimulation (DBS) or sham stimulation to the medial prefrontal cortex (mPFC) of adolescent MIS rats and respective controls, and investigated its behavioral, biochemical, brain-structural and -metabolic effects in adulthood. We found that mPFC-DBS successfully prevented the emergence of deficits in sensorimotor gating, attentional selectivity and executive function in adulthood, as well as the enlargement of lateral ventricle volumes and mal-development of dopaminergic and serotonergic transmission. These data suggest that the mPFC may be a valuable target for effective preventive treatments. This may have significant translational value, suggesting that targeting the mPFC before the onset of psychosis via less invasive neuromodulation approaches may be a viable preventive strategy.


Assuntos
Neurotransmissores/metabolismo , Esquizofrenia/patologia , Animais , Comportamento Animal/fisiologia , Encéfalo/crescimento & desenvolvimento , Encéfalo/metabolismo , Encéfalo/patologia , Estimulação Encefálica Profunda/métodos , Estimulação Encefálica Profunda/psicologia , Modelos Animais de Doenças , Dopamina/farmacologia , Masculino , Neurotransmissores/farmacologia , Córtex Pré-Frontal/patologia , Transtornos Psicóticos/patologia , Ratos , Ratos Wistar , Esquizofrenia/metabolismo , Esquizofrenia/terapia , Filtro Sensorial/fisiologia
19.
Eur J Pain ; 22(2): 402-413, 2018 02.
Artigo em Inglês | MEDLINE | ID: mdl-29105897

RESUMO

BACKGROUND: There is growing evidence for the development of chronic pain after intensive care. Nonetheless, there is only limited knowledge about factors leading to chronic intensive care-related pain (CIRP). Thus, the primary objective was the identification of predictors of CIRP. Moreover, we aimed to assess the impact of CIRP on patients' health-related quality of Life (HRQOL). METHODS: Comprehensive information on patients' pain before ICU admission and present pain was collected longitudinally by means of the German Pain Questionnaire 6 and 12 months after ICU discharge (ICUDC ). In addition, a subsample of patients underwent Quantitative Sensory Testing (QST). We used Generalized Estimating Equations to identify predictors of CIRP with logistic regression models. RESULTS: In total, 204 patients (197/159 at 6/12 months after ICUDC ) were available for the analyses. In the multivariate models, moderate to severe average pain in the 4 weeks after ICUDC , lower age, female sex, increased inflammation and chronic pain conditions and increased levels of anxiety before ICU admission were predictive for CIRP. In addition, small fibre deficits and lower disease severity were associated with CIRP in the QST subsample (81 patients, 77/55 at 6/12 months after ICUDC ). Patients with CIRP reported significantly lower HRQOL than patients without CIRP. CONCLUSIONS: Chronic intensive care-related pain is associated with specific decrements in HRQOL. Knowledge about the identified predictors is of clinical and scientific importance and might help to reduce the incidence of CIRP. SIGNIFICANCE: Chronic intensive care-related pain is associated with specific decrements in health-related quality of life. While most of the identified predictors for CIRP can only be considered as risk factors, especially adequate (post-) acute pain management should be studied as preventive strategy.


Assuntos
Dor Crônica/diagnóstico , Dor Crônica/epidemiologia , Cuidados Críticos , Unidades de Terapia Intensiva , Qualidade de Vida , Idoso , Dor Crônica/etiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Medição da Dor , Alta do Paciente , Prevalência , Inquéritos e Questionários
20.
Acta Anaesthesiol Scand ; 60(8): 1121-30, 2016 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-27324080

RESUMO

BACKGROUND: Many former intensive care unit (ICU) patients report difficulties in cognitive functions especially in their daily life. We aimed to measure perceived cognitive impairments in daily life in survivors of critical illness and their family member controls (FMC). METHODS: Perceived cognitive impairments were assessed two times after ICU discharge using an adapted German version of the "Functional Assessment of Cancer Therapy - Cognitive Function" questionnaire. After 3 months, 127 former patients and 52 FMC participated and 103/127 patients and 36/52 FMC were followed up after 6 months. Baseline information was obtained retrospectively. RESULTS: We found no significant differences between the patient sample and FMC, 3 and 6 months after ICU discharge. Based on questionnaire ratings, cluster analysis divided patients and FMC into a cognitively 'impaired' and a 'non-impaired' cluster. Questionnaire scales differed significantly prior to ICU admission as well as 3 and 6 months after ICU discharge between both clusters. While differences between patients and FMC were less pronounced in the 'non-impaired' cluster, patients were significantly more impaired than FMC at 3 and 6 months after ICU discharge in the 'impaired' cluster. DISCUSSION: A substantial part of former patients were affected by post-ICU cognitive impairment in daily life. Pre-existing cognitive impairments were a risk factor. These patients would probably profit from tailored neurorehabilitative therapy. Therefore, an efficient tool to identify potential patients for neurorehabilitation is needed. The questionnaire revealed good psychometric properties. We recommend a comprehensive validation of the questionnaire in this patient population.


Assuntos
Disfunção Cognitiva/terapia , Estado Terminal/psicologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Família , Feminino , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Inquéritos e Questionários , Sobreviventes
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