Exploring gaps in surveillance of a small measles outbreak in Toronto, Canada.

In early 2015, an outbreak of 10 confirmed measles cases occurred in Toronto, Ontario. As part of the outbreak response, the Toronto Public Health staff conducted both traditional and supplementary case investigation activities. Despite this extensive effort, and unlike many previous measles outbreaks in Canada, neither the source case nor any confirmed epidemiologic links between cases were identified. The outbreak investigation brought to light potential gaps in the current measles surveillance and suggested approaches to future investigations: routine use of social media and other time-stamped resources to enhance case investigation; early and repeated targeted communication with primary care partners to improve case detection; and continued efforts to increase and maintain sufficient immunization coverage to interrupt transmission.

Effect of directly observed preventive therapy for latent tuberculosis infection in San Francisco.

SETTING: San Francisco TB Clinic instituted a directly observed preventive therapy (DOPT) program for treatment of persons with latent TB infection in 1996. OBJECTIVE: To examine therapy completion for latent tuberculosis infection before and after implementation of the DOPT program. DESIGN: Medical records were analyzed for patients at the San Francisco TB Clinic referred from high-risk sites for the periods 1993-1994 (n = 619) and 1997-June 1998 (n = 460). Treatment completion and time of therapy were analyzed comparing DOPT to self-administered therapy (SAT). RESULTS: More DOPT patients completed treatment (70.3%) than SAT patients (47.9%) (P < 0.001). Controlling for sex, age, race/ethnic group and cohort, patients on DOPT were nearly twice as likely to complete therapy (OR 1.93, 95% CI 1.25-3.00). CONCLUSION: DOPT is a successful strategy. Combined with targeted testing, DOPT can have an important impact in areas with traditionally low rates of treatment adherence.

A low-fat diet but not food restriction improves lactational performance in obese rats.

Rats fed a high-fat diet before and during lactation have difficulty initiating lactation and have high pup mortality rates, low milk production and, consequently, poor pup growth. To determine if these adverse outcomes can be mitigated with dietary changes made after delivery, obese Sprague-Dawley rats (who had previously been fed a high-fat diet [AIN-93M, modified to contain 35% fat, w/w]) were assigned at parturition to continue to be fed this diet (HF) or switched to free access to a corresponding low-fat (LF) diet (AIN-93M, 4% fat w/w) or switched to the LF diet and restricted to consuming only 75% of ad libitum intake (LF/R). Dams lost weight during lactation, but weight loss was much less in the LF group (19g) than in the other two groups (47 and 59g, HF and LF/R, respectively). There was no appreciable change in body water; body fat decreased by about half in all groups, but most substantially in the LF/R group. Compared with the HF group, milk production was 50% higher in the LF group and 12% lower in the LF/R group. Milk lipid concentration tended to be higher and milk water concentration lower in the HF compared with the other two groups. Growth of the litters of the LF dams was significantly higher than both HF and LF/R dams. These results indicate that switching to a low-fat diet mitigates the negative effects of obesity and continued high-fat feeding on lactational performance and pup growth. Consumption of restricted quantities of a low-fat diet negatively affected milk production and failed to improve pup growth, despite the dams' mobilization of body fat in support of lactation.

Food supplementation during lactation shortens anestrus and elevates gonadotropins in rats.

Breastfeeding delays the resumption of ovulation in women, a phenomenon particularly important in less developed areas. Although human and animal studies indicate that undernutrition extends the period of lactational anestrus, the effect of improving nutritional status during lactation on this time of infecundability, however, is less clear. To assess the effects of food supplementation on duration of lactational anestrus, Sprague-Dawley rats were assigned to one of three dietary groups: 1) control (C), given unrestricted access to diet AIN-76A; 2) food-restricted (FR), fed 50% of the control intake; and 3) food-supplemented (FS), food-restricted until d 0 of lactation and thereafter given unrestricted access to diet AIN-76A. Time to first detectable proestrus was monitored starting on d 10 of lactation. Nursing behaviors and gonadotropin and prolactin concentrations were measured in both intact and ovariectomized dams on d 10, 15 and 20 of lactation; we report these data only on the ovariectomized group, which represents the more appropriate animal model of human reproductive physiology during lactation. Proestrus returned significantly (P < 0.0001) sooner in both FS (18.1 +/- 2.4 d) and C (18.0 +/- 2.9 d) than in FR (28.8 +/- 2.8 d) intact dams. FS rats had higher luteinizing hormone and follicle stimulating hormone concentrations than FR rats (P < 0.0001 for each). Prolactin concentrations were lower on d 20 than on d 10 of lactation for all groups (P < 0.02), but we found no effect of dietary treatment. FS rats spent more time away from their pups (P < 0.05) and experienced less suckling (P < 0.05) than FR rats on d 15 of lactation. These results indicate that food supplementation of previously underfed rats hastens the return of ovulation and is accompanied by alterations in nursing behaviors.

Documentation of second-by-second breastfeeding behaviors using a novel method.

The specific way nursing patterns influence the duration of postpartum amenorrhea is unknown. This may result from the shortcomings of available methods: the daily log and recall. We tested these against a novel method, an event monitor (EM), consisting of a wrist-worn stopwatch that stores events. Exclusively breastfeeding women (n = 11) were assigned randomly to use each of the three methods twice during a 2-week period surrounding Weeks 4, 8, and 12 postpartum. More nursing episodes were recorded with the EM than log during Week 4 (p < 0.03) and Week 8 (p < 0.02). EM captured more episodes than recall during all study periods (p < 0.004). The EM was considered as acceptable and accurate to mothers as the other methods and, therefore, is a useful option for documenting breastfeeding patterns.

Duration of breastfeeding associated with obesity during adolescence.

The relationship between duration of breastfeeding and obesity (body mass index > or = 85 percentile) at adolescence was investigated in a white, rural population (n = 136) in which confounding by race was absent and confounding by socioeconomic status was expected to be minimal. Relevant data were abstracted from hospital charts. When examined independently, minimal (< or = 2 months) or no breastfeeding was positively associated with adolescent obesity (p < 0.03). This association was present in the lower but not the higher socioeconomic status group. However, when sex, birthweight, and socioeconomic status were included in a multiple regression model, duration of breastfeeding was no longer significantly associated with obesity during adolescence.