1.
Steroids
; 66(7): 569-79, 2001 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11322965
RESUMO
A number of new steroidal 17-spirofuran derivatives of the 19-nor series containing Me, Et or (i)Pr-substituents in the heterocyclic moiety has been prepared, which are expected to have a strong progestagenic activity. The proposed approach made use of the 1-3-dipolar cycloaddition of low-molecular nitrile oxides with steroidal acetylenic alcohols followed by transformation of the isoxazole side chain.