RESUMO
INTRODUCTION: Eating problems are common in patients with chronic obstructive pulmonary disease (COPD), and intake of micronutrients might be lower than recommended. OBJECTIVE: To study dietary intake, serum and urinary concentration of trace elements and vitamins in elderly underweight patients with established severe COPD. METHODS: Outpatients at a university clinic for lung medicine, with COPD, 70-85 years old, with no other serious disease, and with a body mass index (BMI) of Assuntos
Dieta
, Minerais/administração & dosagem
, Doença Pulmonar Obstrutiva Crônica/fisiopatologia
, Vitaminas/administração & dosagem
, Idoso
, Idoso de 80 Anos ou mais
, Cálcio/administração & dosagem
, Proteínas Alimentares/administração & dosagem
, Ingestão de Energia
, Ácidos Graxos/administração & dosagem
, Ácidos Graxos Insaturados/administração & dosagem
, Feminino
, Ácido Fólico/administração & dosagem
, Ácido Fólico/sangue
, Homocisteína/sangue
, Humanos
, Entrevistas como Assunto
, Masculino
, Malonatos/sangue
, Osteoporose/etiologia
, Vitamina D/administração & dosagem
RESUMO
Pulmonary rehabilitation is recommended in international treatment guidelines for chronic obstructive pulmonary disease (COPD). No one has however studied the effect on long-term mortality. The aim of the current study was to study the mortality in a sample of patients with severe COPD included in a 1-year multidisciplinary rehabilitation program. Body composition was assessed at baseline using bioelectrical impedance. Mortality was studied in 86 patients using the Cox proportional hazards model. Forty-seven (55%) of the patients died during the mean follow-up time which was almost 6 years. Risk of mortality increased with increasing age, increasing number of hospital days the year before inclusion and men had higher mortality risk than women. The mortality risk decreased with increasing % reference body weight, increasing fat-free mass index (FFMI), increasing FEV(1) and increasing 6-min walking distance. Gender, age and FFMI continued to be statistical significant predictors of mortality when controlling for the other baseline variables in a multivariate analysis. To conclude, body composition, measured by bioelectrical impedance and presented as FFMI, is an independent predictor of mortality in COPD patients.