RESUMO
Basic fibroblast growth factor (bFGF) is a multifunctional growth factor that may play a significant role in atherosclerotic vascular complications in patients with type 2 diabetes. This study was designed to investigate the association between genetic polymorphisms (-553 T/A, -834 T/A and -921 C/G) in the promoter region of the bFGF gene and myocardial infarction (MI) in 443 patients with type 2 diabetes (149 with MI and 294 with no history of coronary artery disease). The -553 T/A, -834 T/A and -921 C/G polymorphisms of the bFGF gene were found not to be risk factors for MI in patients with type 2 diabetes. The impact of bFGF gene polymorphisms on serum bFGF levels was also investigated and significantly higher serum levels of bFGF were demonstrated in diabetes patients with the TA genotype of the -553 T/A polymorphism compared with diabetes patients with the TT wild type genotype (9.0 +/- 5.6 ng/l versus 3.0 +/- 1.9 ng/l, respectively). Thus, the tested bFGF gene polymorphisms cannot be used as genetic markers for MI in diabetic Caucasians.
Assuntos
Diabetes Mellitus Tipo 2/complicações , Diabetes Mellitus Tipo 2/genética , Fator 2 de Crescimento de Fibroblastos/genética , Infarto do Miocárdio/genética , Polimorfismo de Nucleotídeo Único/genética , Regiões Promotoras Genéticas/genética , Estudos de Casos e Controles , Estudos Transversais , DNA/sangue , DNA/genética , Diabetes Mellitus Tipo 2/sangue , Feminino , Fator 2 de Crescimento de Fibroblastos/sangue , Genótipo , Humanos , Masculino , Pessoa de Meia-Idade , Infarto do Miocárdio/sangue , Infarto do Miocárdio/diagnóstico , Prognóstico , Fatores de Risco , EslovêniaRESUMO
The refractive indices of polywater columns in glass capillaries have been rapidly and accurately measured with an interference microscope. Polywater has been detected by this method in both quartz and Vycor glass capillaries. A comparison of refractive index measurements with measurements of optical anisotropy indicates that polywater initially condenses with an ordered structure.
