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1.
Artigo em Inglês, Francês | MEDLINE | ID: mdl-28102995

RESUMO

In 2007, Health Promotion Ontario (HPO) began working to advance the "profession" of health promotion (HP) in Canada through development of national competencies for health promoters. Their work was continued by the Pan-Canadian Network for Health Promoter Competencies ("the Network"). Funded by the Public Health Agency of Canada, the Network aimed to address (1) the recommendation made by the Canadian Joint Task Group on Public Health Human Resources for function specific competencies (including "HP Specialists"); and (2) the marginalization health promoters face in practice. The current health promoter competencies were released in November 2015, following a series of literature reviews and practitioner consultations.


INTRODUCTION: En 2007, Health Promotion Ontario (HPO) a entrepris de faire progresser la « profession ¼ de praticien en promotion de la santé (PS) au Canada en établissant des compétences nationales à l'intention des promoteurs de la santé. Ce travail a été poursuivi par le Réseau pancanadien pour les compétences des promoteurs de la santé (« le Réseau ¼). Avec le financement de l'Agence de la santé publique du Canada, le Réseau a eu pour mandat, premièrement, de donner suite à la recommandation formulée par le Groupe de travail conjoint sur les ressources humaines en santé publique à propos des compétences spécifiques (notamment pour les « spécialistes de la promotion de la santé ¼) et, deuxièmement, de lutter contre la marginalisation que subissent les promoteurs de la santé dans l'exercice de leurs fonctions. Les compétences des promoteurs de la santé en vigueur actuellement ont été publiées en novembre 2015 à la suite d'une série de revues de la littérature et de consultations auprès de praticiens.


Assuntos
Promoção da Saúde , Humanos , Ontário
2.
Science ; 350(6256): 64-7, 2015 Oct 02.
Artigo em Inglês | MEDLINE | ID: mdl-26272904

RESUMO

Directly detecting thermal emission from young extrasolar planets allows measurement of their atmospheric compositions and luminosities, which are influenced by their formation mechanisms. Using the Gemini Planet Imager, we discovered a planet orbiting the ~20-million-year-old star 51 Eridani at a projected separation of 13 astronomical units. Near-infrared observations show a spectrum with strong methane and water-vapor absorption. Modeling of the spectra and photometry yields a luminosity (normalized by the luminosity of the Sun) of 1.6 to 4.0 × 10(-6) and an effective temperature of 600 to 750 kelvin. For this age and luminosity, "hot-start" formation models indicate a mass twice that of Jupiter. This planet also has a sufficiently low luminosity to be consistent with the "cold-start" core-accretion process that may have formed Jupiter.

3.
J Forensic Leg Med ; 16(2): 53-5, 2009 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-19134996

RESUMO

Approximately 10% of patients who have suffered with whiplash injury will develop otological symptoms such as tinnitus, deafness and vertigo. Some of these are purely subjective symptoms; nevertheless, for the majority there are specific tests that can be undertaken. These tests can quantify the extent and severity of the symptoms as well as provide guidance as to the correct rehabilitation pathway. This article reviews the body of literature relating to the otological aspects of whiplash injury and gives an overview for medical and legal professionals.


Assuntos
Perda Auditiva/etiologia , Zumbido/etiologia , Vertigem/etiologia , Traumatismos em Chicotada/complicações , Perda Auditiva/diagnóstico , Humanos , Índice de Gravidade de Doença , Zumbido/classificação , Vertigem/diagnóstico , Testes de Função Vestibular
4.
Hum Mol Genet ; 14(6): 873-83, 2005 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-15703191

RESUMO

Myotonic dystrophy type 1 is an autosomal dominant disorder associated with the expansion of a CTG repeat in the 3' untranslated region (UTR) of the DMPK gene. Recent data suggest that pathogenesis is predominantly mediated by a gain of function of the mutant transcript. In patients, these expanded CUG repeat-containing transcripts are sequestered into ribonuclear foci that also contain the muscleblind-like proteins. To provide further insights into muscleblind function and the pathogenesis of myotonic dystrophy, we generated Drosophila incorporating CTG repeats in the 3'-UTR of a reporter gene. As in patients, expanded CUG repeats form discrete ribonuclear foci in Drosophila muscle cells that co-localize with muscleblind. Unexpectedly, however, foci are not observed in all cell types and muscleblind is neither necessary nor sufficient for their formation. The foci are dynamic transient structures with short half-lifes that do not co-localize with the proteasome, suggesting they are unlikely to contain mis-folded proteins. However, they do co-localize with non-A, the human orthologs of which are implicated in both RNA splicing and attachment of dsRNA to the nuclear matrix. Muscleblind is also revealed as having a previously unrecognized role in stabilizing CUG transcripts. Most interestingly, Drosophila expressing (CUG)162 repeats has no detectable pathological phenotype suggesting that in contrast to expanded polyglutamine-containing proteins, neither the expanded CUG repeat RNA nor the ribonuclear foci are directly toxic.


Assuntos
Regiões 3' não Traduzidas/metabolismo , Distrofia Miotônica/genética , Proteínas Serina-Treonina Quinases/genética , Estabilidade de RNA/genética , Expansão das Repetições de Trinucleotídeos/genética , Animais , Drosophila melanogaster , Humanos , Distrofia Miotônica/patologia , Miotonina Proteína Quinase , Proteínas Serina-Treonina Quinases/metabolismo
5.
Am J Pathol ; 163(1): 37-45, 2003 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-12819009

RESUMO

Hypermethylation of multiple CpG islands is a common event in cancer. To assess the prognostic values of this epigenetic alteration, we developed Methylation Target Array (MTA), derived from the concept of tissue microarray, for simultaneous analysis of DNA hypermethylation in hundreds of tissue genomes. In MTA, linker-ligated CpG island fragments were digested with methylation-sensitive endonucleases and amplified with flanking primers. A panel of 468 MTA amplicons, which represented the whole repertoire of methylated CpG islands in 93 breast tumors, 20 normal breast tissues, and 4 breast cancer cell lines, were arrayed on nylon membrane for probe hybridization. Positive hybridization signals detected in tumor amplicons, but not in normal amplicons, were indicative of aberrant hypermethylation in tumor samples. This is attributed to aberrant sites that were protected from methylation-sensitive restriction and were amplified by PCR in tumor samples, while the same sites were restricted and could not be amplified in normal samples. Hypermethylation frequencies of the 10 genes tested in breast tumors and cancer cell lines were 60% for GPC3, 58% for RASSF1A, 32% for 3OST3B, 30% for HOXA5, 28% for uPA, 25% for WT1, 23% for BRCA1, 9% for DAPK1, and 0% for KL. Furthermore, hypermethylation of 5 to 7 loci of these genes was significantly correlated with hormone receptor status, clinical stages, and ages at diagnosis of the patients analyzed. This novel approach thus provides an additional avenue for assessing clinicopathological consequences of DNA hypermethylation in breast cancer.


Assuntos
Neoplasias da Mama/genética , Ilhas de CpG , Metilação de DNA , Genoma Humano , Análise de Sequência com Séries de Oligonucleotídeos/métodos , Neoplasias da Mama/patologia , Feminino , Perfilação da Expressão Gênica , Humanos , Dados de Sequência Molecular , Regiões Promotoras Genéticas , Estatística como Assunto , Células Tumorais Cultivadas
6.
Genomics ; 78(3): 155-68, 2001 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-11735222

RESUMO

Human chromosome 2q33 is an immunologically important region based on the linkage of numerous autoimmune diseases to the CTLA4 locus. Here, we sequenced and assembled 2q33 bacterial artificial chromosome (BAC) clones, resulting in 381,403 bp of contiguous sequence containing genes encoding a NADH: ubiquinone oxidoreductase, the costimulatory receptors CD28, CTLA4, and ICOS, and a HERV-H type endogenous retrovirus located 366 bp downstream of ICOS in the reverse orientation. Genomic microarray expression analysis using differentially activated T-cell RNA against a subcloned CTLA4/ICOS BAC library revealed upregulation of CTLA4 and ICOS sequences, plus antisense ICOS transcripts generated by the HERV-H, suggesting a potential mechanism for ICOS regulation. We identified four nonlinked, polymorphic, simple repetitive sequence elements in this region, which may be used to delineate genetic effects of ICOS and CTLA4 in disease populations. Comparative genomic analysis of mouse genomic Icos sequences revealed 60% sequence identity in the 5' UTR and regions between exon 2 and the 3' UTR, suggesting the importance of ICOS gene function.


Assuntos
Antígenos de Diferenciação de Linfócitos T/genética , Antígenos de Diferenciação/genética , Antígenos CD28/genética , Cromossomos Humanos Par 2 , Imunoconjugados , Família Multigênica , Análise de Sequência com Séries de Oligonucleotídeos , Abatacepte , Animais , Antígenos CD , Sequência de Bases , Antígeno CTLA-4 , Cromossomos Artificiais Bacterianos , Humanos , Proteína Coestimuladora de Linfócitos T Induzíveis , Camundongos , Repetições de Microssatélites/genética , Dados de Sequência Molecular , Fases de Leitura Aberta , Mapeamento Físico do Cromossomo , Polimorfismo Genético , Homologia de Sequência do Ácido Nucleico , Especificidade da Espécie
7.
Headache ; 41(9): 910-1, 2001 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-11703483
8.
Int J Soc Psychiatry ; 47(3): 42-54, 2001.
Artigo em Inglês | MEDLINE | ID: mdl-11589335

RESUMO

A sample of 148 (87 Jordanian [61 male, 26 female] and 61 Israeli [26 male, 35 female]) was selected from a psychiatric clinic in Ashdod Israel and Zarka Jordan, using convenience sampling methodology over a 12 month period in late 1997 and early 1998. A revised Hopkins Symptom Checklist: A Self-Report Symptom Inventory (HSCL) was translated into Arabic and Hebrew and distributed to subjects; additional questions explored demographic characteristics, forms of received treatment, patient perceptions of treatment efficacy, patient use of traditional healers, and patient explanation of etiology. Data revealed that there were differences in dimensions between the 2 groups based on nationality and gender. More Jordanians than Israelis expected medications as the main treatment, and unlike Israelis, no Jordanian patients received individual psychotherapy. Israelis expected medications, advice, directions, and instructions from psychiatrists. Both ethnic groups consulted a wide array of traditional healers, although precise types of healers varied according to gender and ethnicity. Israeli subjects gave more diverse explanations of mental health etiologies: physical, family, divorce, economic, unemployment; whereas Jordanians tended to emphasize divine and spiritual sources. Implications for psychiatric practice are discussed.


Assuntos
Instituições de Assistência Ambulatorial , Características Culturais , Etnicidade/psicologia , Transtornos Mentais/psicologia , Serviços de Saúde Mental , Adulto , Idoso , Feminino , Humanos , Islamismo , Israel/etnologia , Jordânia/etnologia , Masculino , Pessoa de Meia-Idade , Marrocos , Escalas de Graduação Psiquiátrica , Religião , Autoavaliação (Psicologia)
10.
J Pers Assess ; 77(3): 508-23, 2001 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-11781036

RESUMO

In this study, we examined the ability of the MMPI-A (Butcher et al., 1992) to detect substance abuse problems in a juvenile correctional setting. Specifically, we evaluated the Alcohol/Drug Problem Acknowledgment scale (ACK; Weed, Butcher, & Williams, 1994), the Alcohol/Drug Problem Proneness scale (PRO; Weed et al., 1994), and the MacAndrew Alcoholism Scale-Revised (MAC-R; Butcher et al., 1992) in the prediction of substance abuse. In addition, the incremental validity of ACK in comparison to PRO was evaluated, as was the incremental validity of PRO in comparison to ACK. The sample consisted of 123 boys and girls from ajuvenile correctional facility in Northeastern Ohio. Results indicate that ACK and PRO, but not MAC-R, were related to interviewer ratings of substance abuse. Results point to the superiority of ACK over PRO in substance abuse identification.


Assuntos
Delinquência Juvenil/psicologia , MMPI/estatística & dados numéricos , Detecção do Abuso de Substâncias/estatística & dados numéricos , Adolescente , Comportamento do Adolescente/psicologia , Análise de Variância , Crime , Feminino , Humanos , Masculino , Valores de Referência
12.
Community Ment Health J ; 36(5): 501-11, 2000 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-10994683

RESUMO

A revised Hopkins Symptom Checklist (HSCL), translated into Arabic, was distributed to a sample of 87 nonpsychotic mental health out-patients in Zarka, Jordan (male = 61, female = 26). Findings revealed no significant gendered differences, but higher responses among women in all dimensions. Regardless of gender, patients also expected and were satisfied with medicinal treatment; explained etiologies as having supernatural origins; and utilized informal community traditional healing and religious healing systems. The supernatural explanations and community healing systems varied by gender. Findings emphasize future treatment and programme development strategies that take into account the biomedical/traditional interface, culturally appropriate treatment modalities, different gendered patient needs, and the potential stigma of professional treatment.


Assuntos
Serviços de Saúde Mental/estatística & dados numéricos , Satisfação do Paciente , Adulto , Idoso , Idoso de 80 Anos ou mais , Características Culturais , Feminino , Humanos , Jordânia , Masculino , Medicina Tradicional , Pessoa de Meia-Idade , Religião , Fatores Sexuais
13.
J Pers Assess ; 74(2): 282-95, 2000 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-10879356

RESUMO

This article describes the development and initial validation of the Infrequency-Psychopathology scale, Fp-A, for the MMPI-A (Butcher et al., 1992). The scale parallels the Infrequency-Psychopathology scale, F(p), that has been developed for the MMPI-2 (Butcher, Dahlstrom, Graham, Tellegen, & Kaemmer, 1989). Results demonstrated that the 40-item Fp-A scale is superior to the F scale at discriminating between faking-bad and accurate reports of psychopathology, although the improvement over F was modest, particularly when compared to the improvement found for the F(p) scale. The difference seemed to reflect the superiority of the MMPI-A F scale to the MMPI-2 F scale. Even so, the findings suggest that the identification of overreporting on the MMPI-A could potentially be enhanced by using Fp-A as an adjunct to the F scale.


Assuntos
MMPI/normas , Simulação de Doença/diagnóstico , Transtornos Mentais/diagnóstico , Adolescente , Feminino , Humanos , Pacientes Internados/estatística & dados numéricos , Masculino , Simulação de Doença/psicologia , Transtornos Mentais/psicologia , New York , Psicometria , Psicopatologia , Estudantes/estatística & dados numéricos
14.
Psychol Assess ; 12(2): 158-65, 2000 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-10887761

RESUMO

The current study examined the effects of validity-scale coaching on one's ability to feign general psychopathology. College students were coached on malingering strategies and completed the MMPI-2. Their responses were compared with students asked to malinger psychopathology without validity-scale coaching and with psychiatric inpatients completing the MMPI-2 under standard instructions. In accordance with previous research (e.g., J. R. Graham, D. Watts, & R. E. Timbrook, 1991), uncoached malingerers were adequately discriminated from patients by using the Infrequency (F) scale. However, as suggested by previous research (R. Rogers, R. M. Bagby, & D. Chakraborty, 1993), the F scale was not as effective at classifying coached malingerers. It was found that other validity indicators, such as the Infrequency Psychopathology Scale were more accurate at discriminating between coached malingerers and hospitalized patients.


Assuntos
MMPI , Simulação de Doença/diagnóstico , Transtornos Mentais/diagnóstico , Prática Psicológica , Adolescente , Adulto , Estudos de Casos e Controles , Feminino , Humanos , Pacientes Internados , Masculino , Valor Preditivo dos Testes , Psicometria , Reprodutibilidade dos Testes
15.
Health Soc Work ; 25(1): 9-22, 2000 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-10689599

RESUMO

Several culturally specific practical considerations should inform social work interventions with ethnic Arab peoples in Arab countries or in Western nations. These include taking into account gender relations, individuals' places in their families and communities, patterns of mental health services use, and, for practice in Western nations, the client's level of acculturation. Such aspects provide the basis for specific guidelines in working with ethnic Arab mental health clients. These include an emphasis on short-term, directive treatment; communication patterns that are passive and informal; patients' understanding of external loci of control and their use of ethnospecific idioms of distress; and, where appropriate, the integration of modern and traditional healing systems.


Assuntos
Árabes/psicologia , Atitude Frente a Saúde/etnologia , Transtornos Mentais/etnologia , Transtornos Mentais/terapia , Serviço Social em Psiquiatria/métodos , Aculturação , Comunicação , Emigração e Imigração , Família/etnologia , Identidade de Gênero , Humanos , Controle Interno-Externo , Relações Profissional-Paciente , Religião e Psicologia
16.
Cult Med Psychiatry ; 23(2): 219-43, 1999 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-10451803

RESUMO

Twenty Bedouin-Arab non-psychotic subjects in Israel (10 male, 10 female) utilized biomedical and traditional healing mental health care systems. Common patterns of utilization were observed: first to family/friends, then to a general practitioner, next to a traditional healer, and finally to a psychiatrist. Men were more familiar with the biomedical system, and women with the traditional. Women, more than men, made group utilization decisions; men, more than women, saw traditional healers outsider their home communities. Gender differences were found in symptomatology and in patient construction of etiology. The biomedical system successfully addressed physical symptoms. The traditional system struck a stronger therapeutic alliance, tended to diagnose more comprehensibly, and was perceived by many patients as being more clinically beneficial. Biomedical practitioners can learn from traditional healers how to read a client's ecological map, incorporate the family/community in treatment, and communicate in the patient's cultural idiom. In their search for models of traditional/biomedical system integration, scholars should turn to patients themselves, who are currently living such integration.


Assuntos
Árabes/psicologia , Cultura , Transtornos Mentais/etnologia , Transtornos Mentais/terapia , Serviços de Saúde Mental/estatística & dados numéricos , Adulto , Medicina Clínica , Feminino , Humanos , Israel/etnologia , Masculino , Medicina Tradicional , Fatores Sexuais
17.
Child Welfare ; 78(2): 283-96, 1999.
Artigo em Inglês | MEDLINE | ID: mdl-10418118

RESUMO

Blood vengeance is a culturally specific phenomenon that can place Bedouin-Arab children at high risk of neglect. This case study examines the psychological and social implications of vengeance on children, the children's coping strategies, and the role of social work. The social work function includes nonauthoritarianism, strategies for forming a positive helping alliance, and various forms of culturally sensitive assessment and intervention. The study therefore yields insight into bridging the emic-etic gap in conceptualizing and responding to child neglect in a non-Western society.


Assuntos
Árabes/psicologia , Maus-Tratos Infantis/prevenção & controle , Maus-Tratos Infantis/psicologia , Cultura , Homicídio/psicologia , Relações Interpessoais , Serviço Social , Adaptação Psicológica , Adolescente , Criança , Serviços de Saúde da Criança/provisão & distribuição , Proteção da Criança , Pré-Escolar , Humanos , Israel
18.
J Reprod Fertil ; 117(1): 35-40, 1999 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-10645243

RESUMO

The effects of nutrient intake and insemination of gilts at first versus third oestrus on the in vitro development of preimplantation pig embryos were investigated. Standard swine management involves ad libitum feeding of gilts at first oestrus and restricted feeding of gilts at third oestrus. According to previous research, gilts inseminated at first oestrus demonstrate greater embryonic mortality than gilts inseminated at third oestrus, and it is possible that differences in nutrient intake between gilts inseminated at first versus third oestrus affect the viability of eggs or embryos. In the present study, experimental gilts were assigned to three treatments: animals designated 1A were inseminated at first oestrus and fed ad libitum; animals designated 3R were inseminated at third oestrus and were fed a restricted diet; and 3A animals were inseminated at third oestrus and fed ad libitum. Embryos collected from each treatment group were cultured in vitro, and data were evaluated according to cell stage at collection. Comparison of treatments 1A and 3R supported the contention of increased embryo mortality in gilts inseminated at first oestrus under normal management conditions. When cultures were initiated at the one- to two-cell or two- to four-cell stages, the percentage of 1A embryos developing to the morula stage (50.9%, 68.0%) was significantly lower than that of 3R embryos (88.9%, 90.9%; P < 0.05). Comparison of treatments 1A and 3A addressed effects due to the number of oestrous cycles. Significantly more two- to four-cell embryos from gilts inseminated at third oestrus and fed ad libitum reached the morula and expanded blastocyst stages of development (87.0%, 41.3%) compared with embryos from gilts inseminated at first oestrus and fed ad libitum (68.0%, 20.3%; P < 0.05). Finally, the effects of ad libitum feeding were determined by comparing treatments 3A and 3R. These data were inconclusive, as both positive and negative effects were observed. More one- to two-cell embryos from treatment 3R developed to the morula stage (88.9%) compared with 3A embryos collected at the same stage (64.7%), whereas a greater number of 3A embryos in the two- to four-cell category reached the expanded blastocyst stage (41.3%) than 3R embryos (21.2%; P < 0.05). These results support the hypothesis of lower in vitro developmental capacity for embryos collected from gilts inseminated at first oestrus. Furthermore, the findings indicate that differences in embryo viability between gilts inseminated at first versus third oestrus are related to the number of oestrous cycles and possibly to differential nutrition.


Assuntos
Fenômenos Fisiológicos da Nutrição Animal , Blastocisto/fisiologia , Estro/fisiologia , Inseminação Artificial , Suínos/fisiologia , Animais , Células Cultivadas , Feminino , Morte Fetal , Gravidez
19.
J Pers Assess ; 70(1): 103-8, 1998 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-9615426

RESUMO

Adolescents (24 boys, 37 girls) from public school settings were given the MMPI-A on 2 occasions with approximately 1 year between testing sessions. Long-term stability of validity, clinical, content, supplementary, and the new Psychopathology Five scales are examined and correlation coefficients are presented. The reliabilities of the MMPI-A scales are consistent with previously reported data. In addition, improvements made during development of the MMPI-A may have led generally to modest increases in stability of the clinical scales for adolescents. Given the importance of both short-term and long-term test-retest data in the evaluation of the validity of an assessment instrument, this study represents an important step in evaluating the validity of the MMPI-A for assessment of personality.


Assuntos
MMPI , Psicometria , Adolescente , Feminino , Humanos , Estudos Longitudinais , Masculino , Ohio , Reprodutibilidade dos Testes
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