[Microbiology and immunology of suppurative surgical infection caused by non spore-forming anaerobes]. / Mikrobiologiia i immunologiia gnoinoi khirurgicheskoi infektsii, vyzvannoi nesporoobrazuiushchimi anaérobami.

Examinations of 230 patients with local pyogenic infection and those of 117 patients with sepsis revealed that asporogenic anaerobes on pure culture were isolated in 17.8% with local pyosis and in 10.2% of patients with sepsis. Anaerobes along with aerobic microbes were found 15.6% of patients with local infection and in 10.2% of patients with sepsis. The involvement of obligate anaerobes in the development of pyogenic infection was displayed by the lower phagocytic activity of neutrophils, the impaired differentiation of lymphocytes, the great increased peripheral blood levels of O-cells, and diminished serum complementary, lysozyme, and overall bactericidal activities and IgM levels.

[Importance of the indices of immunity for predicting the course and assessing the effectiveness of the treatment in acute suppurative lactation mastitis]. / Znachenie pokazatelei immuniteta dlia prognozirovaniia techeniia i otsenki éffektivnosti lecheniia ostrogo gnoinogo laktatsionnogo mastita.

The examination of 47 patients with acute purulent lactation mastitis and 14 patients with the resulting sepsis has shown a decreased level of nonspecific resistance factors. Generalization of the purulent process is characterized by disturbed humoral and cellular links of immunity. The dynamic research of immunity factors can give an estimation of the effectiveness of the chosen treatment and prognosis of possible complications. The general bactericidal activity of blood may be considered one of the most informative indices showing the direction of the process.

[Hyperbaric oxygenation in the complex treatment of complicated forms of acute suppurative mastitis]. / Giperbarooksigenoterapiia v kompleksnom lechenii oslozhnennykh form ostrogo gnoinogo mastita.

HBO was used in the complex of curative measures in 57 patients with complicated course of acute purulent mastitis. Its positive effect upon the external ventilation, general hemodynamics, reduced intoxication, correction of the secondary immune insufficiency and healing of the wounds was shown.

[Activity of T- and B-system lymphocytes in generalized purulent infections]. / Aktivnost' T- i B-sistem limfotsitov pri obshchei gnoinoi infektsii.

The comparison of the results obtained in the study of blood samples taken from 37 septic patients and 60 healthy persons has revealed that general purulent infection is accompanied by a drop in the percentage and absolute content of T-lymphocytes in the peripheral blood, by a rise in the level off D-lymphocytes, by a considerable increase in the number of O-cells. At the same time the patients with general purulent infection show a change in the functional activity of the B-system of lymphocytes, which is manifested by a decrease in the amount of IgM and IgG, an increase in the titers of antibodies to staphylococci, strain 209p. These data suggest that in general purulent infection profound disturbances occur in the immune system of the body.

[State of the nonspecific humoral factors of the body's natural resistance in patients with suppurative and septic infections having various ABO system blood groups]. / Sostoianie nespetsificheskikh gumoral'nykh faktorov estestvennoi rezistentnosti organizma u bol'nykh gnoino-septicheskimi infektsiiami s raznymi gruppami krovi sistemy ABO.

The results of surveying 140 patients with severe purulent and septic infections of staphylococcal etiology, when compared with the distribution of the blood groups (as classified according to the ABO system) in 180 healthy donors, revealed that generalized purulent infections occurred most frequently in patients with blood groups A (II) and AB (IV), and more seldom in patients with blood groups O (I) and B (III). The average content of lysozyme, complement and normal antibodies to E. coli, as well as the average level of general bactericidal activity in the blood sera of the patients were considerably lower than in the blood sera of healthy donors; at the same time content of lysozyme, complement and normal antibodies in the blood sera of patients having different groups of blood did not reflect the degree of their predisposition or resistance to staphylococcal infections. The general bactericidal activity of the blood serum was found to correlate with the degree of predisposition or resistance to purulent septic infections of staphylococcal etiology to a greater extent than other characteristics.