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1.
Arch Clin Neuropsychol ; 36(3): 329-338, 2021 Apr 21.
Artigo em Inglês | MEDLINE | ID: mdl-32064506

RESUMO

OBJECTIVES: Status epilepticus (SE) may lead to or worsen cognitive dysfunction. Few studies have evaluated magnitude and profile of cognitive dysfunction in patients after SE. Characterization of cognitive deficits may be important for rehabilitation and follow-up. We assessed cognitive function in a consecutive, non-selected group of relatively healthy survivors with a comprehensive neuropsychological test battery. METHODS: A total of 33 patients (24 men, 9 women; mean age 54,9 years, mean education 11,8 years) were tested 1 year after SE with Wechsler Adult Intelligence Scale Fourth edition (WAIS-IV), Rey Auditory Verbal Learning Test, subtests from the Wechsler Memory Scale-Revised, Phonemic and Semantic word list generation, and the Halstead-Reitan Battery. Premorbid IQ was estimated with a Norwegian version of the National Adult Reading Test (NART). Results were compared to published norms. Regression analyses and independent groups t-tests were performed to assess the influence of background variables. RESULTS: Mean performance generally was about one standard deviation below average. Full scale IQ (WAIS-IV) was significantly reduced compared to estimated premorbid IQ (NART). Negative influence on cognition of brain lesions visible on computed tomography or magnetic resonance imaging and duration of SE >30 min was shown by group comparisons. CONCLUSIONS: SE represents a marker for possible cognitive dysfunction, and follow-up with neuropsychological assessment and cognitive rehabilitation seems warranted in most patients. Complex problem-solving abilities with high general sensitivity to brain impairment showed the most prominent reduction. Otherwise, no specific profile of domain affection was found. Structural brain lesions and duration of SE over 30 min represent risk factors for cognitive deficit.


Assuntos
Transtornos Cognitivos , Disfunção Cognitiva , Estado Epiléptico , Adulto , Disfunção Cognitiva/complicações , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Testes Neuropsicológicos , Estado Epiléptico/complicações , Escalas de Wechsler
2.
J Stroke Cerebrovasc Dis ; 29(9): 105036, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32807448

RESUMO

AIM: To study the effect of cognitive function, fatigue and emotional symptoms on employment after a minor ischemic stroke compared to non-ST-elevation myocardial infarction (NSTEMI). MATERIAL AND METHODS: We included 217 patients with minor ischemic stroke and 133 NSTEMI patients employed at baseline aged 18-70 years. Minor stroke was defined as modified Rankin scale (mRS) 0-2 at day seven or at discharge if before. Included NSTEMI patients had the same functional mRS. We applied a selection of cognitive tests and the patients completed questionnaires measuring symptoms of anxiety, depression and fatigue at follow up. Stroke patients were tested at three and 12 months and NSTEMI at 12 months. RESULTS: The patients still employed at 12 monthswere significantly younger than the unemployed patients and the NSTEMI patients employed were significantly older than the stroke patients (59 vs 55 years, p < .001). In total, 82 % of stroke patients and 90 % of the NSTEMI patients employed at baseline were still employed at 12 months (p = 06). Stroke patients at work after 12 months had higher education than unemployed patients. There were no difference between employed and unemployed patients in risk factors or location of cerebral ischemic lesions. Cognitive function did not change significantly in the stroke patients from three to 12 months. For stroke patients, we found a significant association between HADS-depression and unemployment at 12 months (p = 04), although this association was not present at three months. Lower age and higher educational level were associated with employment at 12 months for all patients. DISCUSSION AND CONCLUSION: Age and education are the main factors influencing the ability to stay in work after a minor stroke. Employed stroke patients were younger than the NSTEMI patients, but there was no difference in the frequencies in remaining employed. The employment rate at 12 months was high despite the relatively high prevalence of cognitive impairment in both groups.


Assuntos
Cognição , Emoções , Emprego/psicologia , Fadiga/psicologia , Infarto do Miocárdio sem Supradesnível do Segmento ST/psicologia , Acidente Vascular Cerebral/psicologia , Adolescente , Adulto , Fatores Etários , Idoso , Escolaridade , Fadiga/diagnóstico , Fadiga/epidemiologia , Feminino , Nível de Saúde , Humanos , Masculino , Saúde Mental , Pessoa de Meia-Idade , Infarto do Miocárdio sem Supradesnível do Segmento ST/diagnóstico , Infarto do Miocárdio sem Supradesnível do Segmento ST/epidemiologia , Infarto do Miocárdio sem Supradesnível do Segmento ST/fisiopatologia , Noruega/epidemiologia , Prevalência , Prognóstico , Retorno ao Trabalho/psicologia , Medição de Risco , Fatores de Risco , Acidente Vascular Cerebral/diagnóstico , Acidente Vascular Cerebral/epidemiologia , Acidente Vascular Cerebral/fisiopatologia , Fatores de Tempo , Desemprego/psicologia , Adulto Jovem
4.
Acta Neurol Scand ; 140(4): 281-289, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31265131

RESUMO

OBJECTIVES: To study the development of cognitive and emotional symptoms between 3 and 12 months after a minor stroke. MATERIAL AND METHODS: We included patients from stroke units at hospitals in the Central Norway Health Authority and from Haukeland University Hospital. We administered a selection of cognitive tests, and the patients completed a questionnaire 3 and 12 months post-stroke. Cognitive impairment was defined as impairment of ≥2 cognitive tests. RESULTS: A total of 324 patients completed the 3-month testing, whereas 37 patients were lost to follow-up at 12 months. The results showed significant improvement of cognitive function defined as impairment of ≥2 cognitive tests (P = .03) from months 3 to 12. However, most patients still showed cognitive impairment at 12 months with a prevalence of 35.4%. There is significant association between several of the cognitive tests and hypertension and smoking (P = .002 and .05). The prevalence of depression, but not anxiety, increased from 3 to 12 months (P = .04). The prevalence of fatigue did not change and was thus still high with 29.5% after 12 months. CONCLUSIONS: This study shows that an improvement of cognitive function still occurs between 3 and 12 months. Despite this, the prevalence of mostly minor cognitive impairment still remains high 12 months after the stroke. The increasing prevalence of depressive symptoms highlights the importance of being vigilant of depressive symptoms throughout the rehabilitation period. Furthermore, high prevalence of fatigue persisted.


Assuntos
Ansiedade/epidemiologia , Disfunção Cognitiva/epidemiologia , Depressão/epidemiologia , Fadiga/epidemiologia , Acidente Vascular Cerebral/epidemiologia , Adulto , Idoso , Ansiedade/diagnóstico por imagem , Ansiedade/psicologia , Disfunção Cognitiva/diagnóstico por imagem , Disfunção Cognitiva/psicologia , Estudos de Coortes , Depressão/diagnóstico por imagem , Depressão/psicologia , Fadiga/diagnóstico por imagem , Fadiga/psicologia , Feminino , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Noruega/epidemiologia , Acidente Vascular Cerebral/diagnóstico por imagem , Acidente Vascular Cerebral/psicologia
5.
Stroke Res Treat ; 2019: 2527384, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31057784

RESUMO

AIM: To study the prevalence of cognitive and emotional impairment following a minor ischemic stroke compared to an age-matched group with non-ST-elevation myocardial infarction (NSTEMI). METHODS: We included patients aged 18-70 years with a minor ischemic stroke defined as modified Rankin Scale (mRS) 0-2 at day 7 or at discharge if before and age-matched NSTEMI patients with the same functional mRS. We applied a selection of cognitive tests and the patients completed a questionnaire comprising of Hospital Anxiety and Depression scale (HADS) and Fatigue Severity Scale (FSS) at follow-up 12 months after the vascular event. Results of cognitive tests were also compared to normative data. RESULTS: 325 ischemic stroke and 144 NSTEMI patients were included. There was no significant difference in cognitive functioning between ischemic stroke and NSTEMI patients. Minor stroke patients and to a lesser extent NSTEMI patients scored worse on more complex cognitive functions including planning and implementation of activities compared to validated normative data. For the minor stroke patients the location of the ischemic lesion had no influence on the result. The prevalence of anxiety, depression, and fatigue was significantly higher in the stroke group compared to the NSTEMI group. Depression was independently associated with reduced cognitive function. DISCUSSION AND CONCLUSION: Minor ischemic stroke patients, and to lesser degree NSTEMI patients, had reduced cognitive function compared to normative data, especially executive functioning, on 12-month follow-up. The difference in cognitive function between stroke and NSTEMI patients was not significant. Depression was associated with low scores on cognitive tests highlighting the need to adequately address emotional sequelae when considering treatment options for cognitive disabilities.

6.
J Trauma Acute Care Surg ; 84(6S Suppl 1): S125-S131, 2018 06.
Artigo em Inglês | MEDLINE | ID: mdl-29613950

RESUMO

BACKGROUND: The success of implementing damage control resuscitation principles pre-hospital has been at the expense of several logistic burdens including the requirements for resupply, and the question of donor safety during the development of whole blood programs. Previous studies have reported effects on physical performance after blood donation; however, none have investigated the effects of blood donation on cognitive performance. METHOD: We describe a prospective double-blinded, randomized, controlled study comprised of a battery of tests: three cognitive tests, and VO2max testing on a cycle ergometer. Testing was performed 7 days before blinded donation (baseline day), immediately after donation (Day 0), and 7 days (Day 7) after donation. The inclusion criteria included being active blood donors at the Haukeland University Hospital blood bank, where eligibility requirements were met on the testing days, and providing informed consent. Participants were randomized to either the experimental (n = 26) or control group (n = 31). Control group participants underwent a 'mock donation" in which a phlebotomy needle was placed but blood was not withdrawn. RESULTS: In the experimental group, mean ± SEM VO2max declined 6% from 41.35 ± 1.7 mLO2/(min·kg) at baseline to 39.0 ± 1.6 mLO2/(min·kg) on Day 0 and increased to 40.51 ± 1.5 mLO2/(min·kg) on Day 7. Comparable values in the control group were 42.1 ± 1.8 mLO2/(min·kg) at baseline, 41.6 ± 1.8 mLO2/(min·kg)) on Day 1 (1% decline from baseline), and 41.8 ± 1.8 mLO2/(min·kg) on Day 7.Comparing scores of all three cognitive tests on Day 0 and Day 7 showed no significant differences (p > 0.05). CONCLUSION: Our main findings are that executive cognitive and physical performances were well maintained after whole blood donation in healthy blood donors. The findings inform postdonation guidance on when donors may be required to return to duty. LEVEL OF EVIDENCE: Randomized, controlled, double-blinded prospective trial study, level 1.


Assuntos
Doadores de Sangue , Cognição , Aptidão Física , Adulto , Doadores de Sangue/psicologia , Método Duplo-Cego , Função Executiva , Teste de Esforço , Feminino , Humanos , Masculino , Testes Neuropsicológicos , Consumo de Oxigênio , Estudos Prospectivos , Teste de Stroop , Fatores de Tempo
7.
Epilepsy Res ; 140: 39-45, 2018 02.
Artigo em Inglês | MEDLINE | ID: mdl-29227799

RESUMO

OBJECTIVES: Status epilepticus (SE) is considered a risk for cognitive impairment. Studies have indicated that SE cause more cognitive decline than multiple lifetime generalized tonic clonic (GTC) seizures. The aim of the study was to investigate whether patients suffering from SE or from multiple lifetime GTC seizures have cognitive dysfunction, and if the disabilities differ between these groups. MATERIALS AND METHODS: Patients suffering from SE were evaluated shortly after the clinical post-ictal phase and again after one year. Their follow-up results were compared to results from patients with ≥10 GTC seizures and a group of control subjects. Tests from Cambridge Neuropsychological Test Automated Battery (CANTAB) were used. Motor Screening Test (MOT) assessed motor speed, Delayed Matching to Sample (DMS) and Paired Associates Learning (PAL) assessed memory, and Stockings of Cambridge (SOC) assessed executive function. Estimated premorbid IQ and radiologically visible brain lesions were controlled for in adjusted results. Outcome measures were z-scores, the number of standard deviations a score deviates from the mean of a norm population. Negative z-scores indicate poor performance. RESULTS: After the clinical post-ictal phase, performances of SE patients were poor on all domains (n = 46). Mean z-scores with 95% confidence intervals were below zero for tests of psychomotor speed, executive thinking times and memory. Both SE patients at follow-up (n = 39) and patients with multiple GTC seizures (n = 24) performed poorer than controls (n = 20) on tests of memory. These group differences remained significant after covariate adjustments. SE patients at follow-up scored below patients with multiple GTC seizures on tests of psychomotor speed (mean difference -0.59, P = 0.020), but after adjusting for covariates this difference was no longer significant. CONCLUSIONS: Our data do not allow a firm conclusion as to whether SE is a more pronounced risk factor for cognitive dysfunction than repeated generalized tonic clonic seizures. In both patient groups, memory and learning dysfunction remained significant after adjusting for estimated premorbid IQ and structural brain lesions.


Assuntos
Cognição , Convulsões/psicologia , Adulto , Disfunção Cognitiva/etiologia , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Convulsões/complicações , Convulsões/tratamento farmacológico
8.
Epileptic Disord ; 18(3): 297-304, 2016 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-27506857

RESUMO

AIM: Status epilepticus (SE) can lead to sequelae or even death. Identifying characteristics associated with poor outcome is crucial in guiding patient treatment. Based on our retrospective patient cohorts, potential prognostic factors were analysed. METHODS: Patients consecutively treated for refractory convulsive status epilepticus (CSE) between 2001 and 2010 and non-convulsive status epilepticus (NCSE) between 2004 and 2009 were studied. Outcome was compared to prognostic variables. Index SE episodes were used for the statistical analyses. Crosstabs and independent samples t-test were applied. Due to sample size, logistic regression was performed for the combined groups. RESULTS: In total, 50% (9/18) of index refractory CSE and 42% (16/38) of index NCSE episodes led to sequelae. Refractory CSE requiring narcosis for >20 hours was associated with poor outcome (p=0.05). De novo presentation (p=0.0001), long-lasting SE (>2 hours) (p=0.014), age >65 years (p=0.002), and refractory SE (p=0.047) were predictors of poor outcome following NCSE. Based on logistic regression for combined refractory CSE and NCSE, de novo presentation was identified as the strongest predictor of sequelae. CONCLUSIONS: Older age and de novo SE are predictors of sequelae following NCSE. Prolonged SE is a risk factor for poor outcome, both for refractory CSE and NCSE. Aggressive initial treatment to terminate seizures during the early phase is therefore essential.


Assuntos
Avaliação de Resultados em Cuidados de Saúde , Estado Epiléptico/diagnóstico , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , Fatores de Risco , Estado Epiléptico/tratamento farmacológico , Adulto Jovem
9.
Resuscitation ; 89: 13-8, 2015 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-25596374

RESUMO

AIM: Neuropsychological testing has uncovered cognitive impairment in cardiac arrest survivors with good neurologic outcome according to the cerebral performance categories. We investigated cognitive function and health-related quality of life four years after cardiac arrest. METHODS: Thirty cardiac arrest survivors over the age of 18 in cerebral performance category 1 or 2 on hospital discharge completed the EQ-5D-5L and HADS questionnaires prior to cognitive testing using the Cambridge Neuropsychological Test Automated Battery. The results were compared with population norms. RESULTS: Twenty-nine per cent of patients were cognitively impaired. The pattern of cognitive impairment reflects dysfunction in the medial temporal lobe, with impaired short-time memory and executive function slightly but distinctly affected. There was a significant reduction in quality of life on the EQ-VAS, but not on the EQ index. CONCLUSION: Cognitive impairment four years after cardiac arrest affected more than one quarter of the patients. Short-term memory was predominantly affected.


Assuntos
Transtornos Cognitivos/epidemiologia , Nível de Saúde , Parada Cardíaca/complicações , Parada Cardíaca/psicologia , Qualidade de Vida/psicologia , Idoso , Reanimação Cardiopulmonar , Estudos de Casos e Controles , Estudos de Coortes , Cuidados Críticos , Feminino , Parada Cardíaca/terapia , Humanos , Hipotermia Induzida , Tempo de Internação , Masculino , Pessoa de Meia-Idade , Testes Neuropsicológicos , Noruega , Fatores de Tempo
10.
Seizure ; 24: 102-6, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25458101

RESUMO

PURPOSE: Our objective was to study the semiology, aetiology, treatment and outcome of nonconvulsive status epilepticus (NCSE) in adults. METHODS: All NCSE episodes in an unselected hospital cohort in the period 2004-2009 were identified, and the files reviewed. STESS (Status Epilepticus Severity Scale) was conducted retrospectively and correlated to outcome. Follow-up was undertaken after >2 years. RESULTS: 48 NCSEs in 39 patients, 22 men and 17 women, were found. Mean age was 63 years. 23/39 (59%) patients had established epilepsy. The underlying cause of NCSE was cerebrovascular disease in 17/39 (44%). 37/48 (77%) NCSEs were complex focal status epilepticus. 3/48 NCSEs (6.3%) lead to death, whereas 8.5% lead to severe sequelae. Cognitive sequelae were found after 14.9% of NCSEs. The outcome was worst in the group with no prior epilepsy (p=0.013). STESS had a negative predictive value of 96% (cut-off value of 3) for severe sequelae and death combined (p<0.002). CONCLUSIONS: NCSE has a potential for severe sequelae and represents an emergency in need of intensive treatment. The major determinant of outcome is the underlying cause. The outcome was worse in patients without epilepsy than in patients with epilepsy. STESS is of value in predicting outcome. Cognitive sequelae following NCSE can occur, but need further investigation with prospective, systematic studies.


Assuntos
Epilepsia Generalizada/etiologia , Epilepsia Generalizada/terapia , Estado Epiléptico/etiologia , Estado Epiléptico/terapia , Resultado do Tratamento , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Anticonvulsivantes/uso terapêutico , Estudos de Coortes , Eletroencefalografia , Epilepsia Generalizada/complicações , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Avaliação de Resultados em Cuidados de Saúde , Índice de Gravidade de Doença , Estado Epiléptico/complicações , Adulto Jovem
11.
Scand J Psychol ; 54(3): 179-87, 2013 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-23398027

RESUMO

The objective of the paper is to explore bottom-up auditory and top-down cognitive processing abilities as part of long-term outcome assessment of preterm birth. Fifty-five adolescents (age 13-15) born with very low birth weight (VLBW) were compared to 80 matched controls born to term, using three consonant-vowel dichotic listening (DL) instruction conditions (non-forced, forced-right and forced-left). DL scores were correlated with cortical gray matter thickness derived from T1-weighted structural MRI volumes using FreeSurfer to examine group differences also in the neural correlates of higher cognitive processes. While showing normal bottom-up processing, VLBW adolescents displayed impaired top-down controlled conflict processing related to significant cortical thickness differences in left superior temporal gryus and anterior cingulate cortex. Preterm birth with VLBW induces fundamental changes in brain function and structure posing a risk for long-term neurocognitive impairments. Deficits emerge in situations of increasing cognitive conflict and can be related to measures of executive functions as well as morphology.


Assuntos
Córtex Cerebral/fisiopatologia , Transtornos Cognitivos/etiologia , Transtornos Cognitivos/fisiopatologia , Recém-Nascido Prematuro/fisiologia , Recém-Nascido de muito Baixo Peso/fisiologia , Adolescente , Percepção Auditiva/fisiologia , Córtex Cerebral/patologia , Transtornos Cognitivos/patologia , Função Executiva/fisiologia , Feminino , Humanos , Recém-Nascido , Masculino , Risco
12.
Dement Geriatr Cogn Dis Extra ; 1(1): 409-17, 2011 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-22187548

RESUMO

BACKGROUND: A pattern characterizing cognitive deficits in mild stroke could help in differential diagnosis and rehabilitation planning. METHODS: Fifty patients with mild stroke (modified Rankin scale ≤2 at discharge) aged >60 years were given the Mini Mental State Examination (MMSE), the Hopkins Verbal Learning Test-Revised (HVLT-R) and the Stroop test. RESULTS: On HVLT-R, significant impairments were found in learning and recall, but not in delayed recall. The Stroop test revealed significant impairments in reading speed, but not in color-word interference. Using the MMSE, significant deficits were only found in the youngest age group. CONCLUSION: Elderly patients with mild stroke show deficits in verbal learning/recall and in reading speed, but not in the MMSE, delayed recall or color-word interference. The deficits are consistent with a mild-to-moderate brain dysfunction, with relative sparing of medial brain structures.

13.
J Pediatr ; 158(4): 555-561.e4, 2011 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21130467

RESUMO

OBJECTIVE: To evaluate the effect of a computerized working memory training program on both trained and non-trained verbal aspects of working memory and executive and memory functions in extremely low birth weight (ELBW; <1000 g) infants. STUDY DESIGN: Sixteen ELBW infants and 19 term-born control subjects aged 14 to 15 years participated in the training program, and 11 adolescents were included as a non-intervention group. Extensive neuropsychological assessment was performed before and immediately after training and at a 6-month follow-up examination. Both training groups used the CogMed RM program at home 5 days a week for 5 weeks. RESULTS: Both groups improved significantly on trained and non-trained working memory tasks and on other memory tests indicating a generalizing effect. Working memory capacity was improved, and effects were maintained at the 6-month follow-up examination. There was no significant improvement in the non-intervention group at the 6-week follow-up examination. CONCLUSIONS: The computerized training program Cogmed RM was an effective intervention tool for improving memory and reducing core learning deficits in adolescents born at ELBW.


Assuntos
Recém-Nascido de Peso Extremamente Baixo ao Nascer , Memória de Curto Prazo , Instruções Programadas como Assunto , Adolescente , Deficiências do Desenvolvimento , Seguimentos , Humanos , Recém-Nascido , Testes Neuropsicológicos , Classe Social , Aprendizagem Verbal
14.
Dev Med Child Neurol ; 52(12): 1133-8, 2010 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-21175467

RESUMO

AIM: the aim of this study was to assess cognitive function at the age of 19 years in individuals of very low birthweight (VLBW; ≤ 1500g) and in term-born comparison individuals. METHOD: in this hospital-based follow-up study, 55 VLBW participants (30 males, 25 females; mean birthweight 1217g, SD 233g; mean gestational age 29.1wks, SD 2.5wks) and 81 comparison individuals (42 males, 39 females; mean birthweight 3707g, SD 433g; mean gestational age 39.7wks, SD 1.2wks) were examined with a standardized IQ test (Wechsler Adult Intelligence Scale III) to assess general cognitive ability. RESULTS: over half (53%) of the VLBW participants achieved a low IQ score (defined as >1SD below the mean in the comparison group; odds ratio 6.4 vs comparison individuals; 95% confidence interval 2.8-14.4; p<0.001). None of the VLBW group, compared with 22% of the comparison individuals, achieved a high IQ score (>1SD above the comparison mean). VLBW participants scored lower than comparison individuals on full, verbal, and performance IQ, as well as on all four indices (p ≤0.001). The subtest profile indicated problems on all subtests, but especially on those related to arithmetic and visual-perceptual tasks. INTERPRETATIONS: few studies have undertaken a comprehensive assessment of general cognitive outcome (IQ) among young adults of VLBW. Our results indicate that VLBW seems to have a global and lasting impact on cognitive ability. Full-scale IQ assessment may reveal important learning problems in young adults of VLBW, and should be performed to inform appropriate assistance to enhance academic achievement and the chances of permanent employment as adults.


Assuntos
Desenvolvimento Infantil/fisiologia , Cognição/fisiologia , Recém-Nascido de muito Baixo Peso , Nascimento Prematuro/fisiopatologia , Logro , Feminino , Idade Gestacional , Humanos , Recém-Nascido , Inteligência , Estudos Longitudinais , Masculino , Testes Neuropsicológicos , Estigma Social , Estatística como Assunto , Estatísticas não Paramétricas , Adulto Jovem
15.
Epilepsy Behav ; 16(1): 172-4, 2009 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-19435586

RESUMO

Mutations in the catalytic subunit of polymerase gamma (POLG1) produce a wide variety of neurological disorders including a progressive ataxic syndrome with epilepsy: mitochondrial spinocerebellar ataxia and epilepsy (MSCAE). Our earlier studies of patients with this syndrome raised the possibility of more prominent right than left hemisphere dysfunction. To investigate this in more detail, eight patients (six women, two men; mean age: 22.3 years) were studied. All completed an intelligence test (Wechsler Adult Intelligence Scale; WAIS), and four were also given memory tests and a comprehensive neuropsychological test battery. Patients with MSCAE showed significant cognitive dysfunction. Mean Verbal IQ (84.3) was significantly better than Performance IQ (71.8) (t=5.23, P=0.001), but memory testing and neuropsychological testing failed to detect a consistent unilateral dysfunction. Further studies are needed to define the profile and development of cognitive symptoms in this disorder.


Assuntos
DNA Polimerase Dirigida por DNA/genética , Epilepsia/genética , Epilepsia/psicologia , Mutação/fisiologia , Ataxias Espinocerebelares/genética , Ataxias Espinocerebelares/psicologia , Adolescente , Adulto , DNA Polimerase gama , Função Executiva/fisiologia , Feminino , Humanos , Testes de Inteligência , Masculino , Memória/fisiologia , Testes Neuropsicológicos , Adulto Jovem
16.
J Neurol ; 256(3): 349-54, 2009 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-19266144

RESUMO

OBJECTIVE: Guillain- Barré syndrome (GBS) and poliomyelitis may cause life-long health problems. We studied fatigue, pain and muscular weakness in both conditions to define possible interactions between these symptoms and their influence on residual disability and daily functioning. METHODS: We studied 50 patients with previous GBS, 89 patients with a history of poliomyelitis and a reference group of 81 people with similar sex and age and no history of poliomyelitis or GBS using the Fatigue Severity Scale, self-reported pain and muscular weakness Disability Rating Index, and Positive and Negative Affect Schedule (PANAS-X). We assessed the quality of life using the SF-36 Health Survey. RESULTS: The mean score on the Fatigue Severity Scale was significantly higher in the GBS and poliomyelitis patients than in the reference group. This was true also in the subgroups of mild disease, i. e., nonparalytic polio and initial Hughes score less than 3 in the GBS group. Thirty-four percent of GBS patients and 63 % of poliomyelitis patients reported pain; 13 % of GBS and 36 % of poliomyelitis patients reported residual muscle weakness. Fatigue, pain, and muscle weakness interacted in both diseases. Perceived health problems influenced all aspects of the quality of life except mental health in both diseases. CONCLUSIONS: Fatigue, pain, and muscle weakness are common sequelae after GBS and poliomyelitis. The symptoms interact with each other and contribute to long-term disability.


Assuntos
Fadiga/etiologia , Síndrome de Guillain-Barré/complicações , Debilidade Muscular/etiologia , Dor/etiologia , Poliomielite/complicações , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Análise de Variância , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Qualidade de Vida , Índice de Gravidade de Doença , Inquéritos e Questionários , Adulto Jovem
17.
Scand J Psychol ; 47(3): 163-70, 2006 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-16696839

RESUMO

Fifty right-handed patients with focal temporal lobe epilepsy were administered a dichotic listening test with consonant-vowel syllables under non-forced, forced right and forced left attention conditions, and a neuropsychological test battery. Dichotic listening performance was compared in subgroups with and without left hemisphere cognitive dysfunction, measured by the test battery, and in subgroups with left and right temporal epileptic focus. Left hemisphere cognitive dysfunction led to more correct responses to left ear stimuli in all three attention conditions, and fewer correct responses to right ear stimuli in the non-forced attention condition. This was probably caused by basic left hemisphere perceptual dysfunction. Dichotic listening was less affected by a left-sided epileptic focus than by left hemisphere cognitive dysfunction. General cognitive functioning influenced dichotic listening performance stronger in forced than in non-forced attention conditions. Larger cerebral networks were probably involved in the forced attention conditions due to the emphasis on conscious effort.


Assuntos
Transtornos da Percepção Auditiva/fisiopatologia , Epilepsia do Lobo Temporal/fisiopatologia , Lateralidade Funcional , Adulto , Atenção , Testes com Listas de Dissílabos , Feminino , Humanos , Masculino , Testes Neuropsicológicos
18.
Epilepsy Behav ; 8(3): 565-74, 2006 May.
Artigo em Inglês | MEDLINE | ID: mdl-16616647

RESUMO

We hypothesized that brain activation during encoding and retrieval of visual material differed between epilepsy patients with hippocampal sclerosis (HS) and healthy controls. Eleven patients with epilepsy and HS and nine age- and education-matched control subjects were tested during functional MRI recording. A three-block design for visuospatial memory encoding and retrieval and an interference interval longer than 1 minute without memory tasks were used. All subjects revealed parietal, occipital, and prefrontal activation patterns during encoding. Interference revealed parietal more than occipital activation, whereas retrieval revealed asymmetrical frontal and parietal activation. Patients demonstrated a relative increase in occipitoparietal versus frontal cortical activation as compared with controls. Memory performance did not differ between patients and controls. The increased activation in occipitoparietal versus frontal areas in the patients suggests cortical reorganization of visuospatial recognition memory in epilepsy patients with HS. The study is limited by other factors that may contribute to the results, for example, antiepileptic drugs, effects of greater cognitive effort allocated in patients than controls, and possibly subclinical epileptic activity. However, normal visuospatial memory performance in our patients with HS suggests successful network plasticity.


Assuntos
Epilepsia do Lobo Temporal/fisiopatologia , Lobo Frontal/fisiologia , Hipocampo/patologia , Rememoração Mental/fisiologia , Lobo Parietal/fisiologia , Adulto , Epilepsia do Lobo Temporal/psicologia , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Tempo de Reação , Percepção Espacial/fisiologia , Percepção Visual/fisiologia
19.
Int J Neurosci ; 113(9): 1177-96, 2003 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-12959738

RESUMO

This study evaluated the relative effect of left hemisphere dysfunction and side of seizure onset on dichotic listening performance in patients with temporal lobe epilepsy and left hemisphere speech dominance. Seventeen patients were divided into groups based on side of seizure onset and based on scores on a composite measure revealing left hemisphere dysfunction. The group with left hemisphere dysfunction had more correct responses from the left ear, and a left ear advantage, on dichotic listening. The group with normal left hemisphere function showed the expected right ear advantage. Side of seizure onset did not affect dichotic listening performance significantly.


Assuntos
Percepção Auditiva/fisiologia , Testes com Listas de Dissílabos , Epilepsia do Lobo Temporal/fisiopatologia , Lateralidade Funcional/fisiologia , Estimulação Acústica , Adolescente , Adulto , Amobarbital , Mapeamento Encefálico , Epilepsia do Lobo Temporal/diagnóstico , Feminino , Lateralidade Funcional/efeitos dos fármacos , Humanos , Masculino , Pessoa de Meia-Idade , Testes Neuropsicológicos
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