RESUMO
Sodium selenite given in drinking water in a 4 ppm solution during the whole experiment was found to significantly inhibit pleural carcinogenesis induced in Wistar rats by intrapleural injection of chrysotile-asbestos powder (20 mg three times, monthly, in 0.5 ml of physiologic saline). Mesothelioma of the pleura was induced in 20.5%. However, chrysotile alone induced tumor in 43.8%. Sodium selenite failed to influence carcinogenesis in other sites. Possible mechanisms of sodium selenite action are discussed.
Assuntos
Asbestos Serpentinas/toxicidade , Neoplasias Pleurais/induzido quimicamente , Neoplasias Pleurais/prevenção & controle , Selenito de Sódio/administração & dosagem , Animais , Asbestos Serpentinas/administração & dosagem , Distribuição de Qui-Quadrado , Avaliação Pré-Clínica de Medicamentos , Poeira/efeitos adversos , Feminino , Masculino , Neoplasias Pleurais/mortalidade , Ratos , Ratos WistarRESUMO
Phillipsite dust was intrapleurally administered to random-bred rats by 20 mg in 0.5 ml of saline three times with an interval of a month. Higher incidence of hemoblastoses has been experimentally found in exposed animals compared to the control ones. One rat developed pleural mesothelioma, two rats lung adenocarcinoma. It was concluded that phillipsite has weak carcinogenic activity.