Effect of polyunsaturated phosphatidyl-choline on lipid transport system in alcoholic liver injury.

The aim of this study was to determine whether serum lipid composition and lipolytic activities in alcoholinduced liver dystrophy were modified by the co-administration of polyunsaturated phosphatidylcholine (PPC). Chronic alcohol intoxication was induced in rats by intragastric ethanol administration of 3.5 g/kg body weight per day over 56 days. Aqueous PPC suspension was given intragastrally in doses of 100 and 300 mg/kg body weight. Chronic alcohol intoxication led to the development of protein and lipid dystrophy of hepatocytes. PPC partially prevented alcoholic injury of the liver cells and had a normalizing effect on cholesterol esterification, lipolysis of lipoproteins and on the fatty acid composition of the main lipoprotein classes.

[Effect of polyunsaturated phosphatidylcholine on the activity of antioxidant and lipolytic enzymes in alimentary hypercholesterolemia in irradiated rats]. / Deistvie polinenasyshchennogo fosfatidylkholina na aktivnost' antioksidantnykh i lipoliticheskikh fermentov pri alimentarnoi giperkholesterinemii u obluchennykh krys.

A high-cholesterol diet containing 3.5% cholesterol, 0.2% methyl thiouracil and 20% of heated sunflower-seed oil caused an increase in the content of cholesterol, triacylglycerols, diene conjugates and in the activity of phospholipase A2 in rat liver and of serum total cholesterol and cholesterol of low density lipoproteins, and a decrease in the activity of hepatic cholesterol esterase, in the fractional activity of lecithin:cholesterol acetyl transferase (LCAT), in the activity of the enzymes involved in the lipolytic transformation of lipoproteins and in the serum levels of very low density lipoprotein cholesterol. The content of malonic dialdehyde in liver tissue and molar activity of LCAT in blood serum were increased after preirradiation (0.5 and 5.0 Gy) of rats kept on the cholesterol diet. The preparation of polyunsaturated phosphatidylcholine was shown to decrease the content of triacylglycerols and diene conjugates in liver tissue of rats with alimentary hypercholesterolemia. In rats irradiated in a dose of 0.5 Gy the phosphatidylcholine preparation decreased the content of cholesterol in liver tissue and blood serum, exhibited the normalizing effect on the content of cholesterol of high density lipoproteins, on the activity of superoxide dismutase and glutathione peroxidase; in a dose of 5.0 Gy this phosphatidylcholine preparation normalized the content of malonic dialdehyde, activity of the enzymes involved in lipolytic transformation of lipoproteins and increased the LCAT activity.