RESUMO
We evaluated the effect of IV crystalloid administration on hematocrit in 28 healthy, nonbleeding volunteers. Normal saline boluses of 10, 20, and 30 mL/kg were delivered at a mean rate of 115 +/- 4 mL/min, followed by a continuous infusion of either 1 or 5 mL/kg/hr. Hematocrit values determined immediately after bolus infusion declined from baseline a mean +/- SEM of 4.5 +/- 0.6 (P less than .001), 6.1 +/- 0.4 (P less than .001) and 6.3 +/- 0.6 points (P less than .001) in the 10, 20, and 30 mL/kg groups, respectively. Twenty minutes into the maintenance infusion, hematocrits had risen 1.5 +/- 0.8 (P = .03), 2.4 +/- 0.4 (P = .004) and 2.3 +/- 0.7 points (P = .005) when compared with post-bolus hematocrits in the 10, 20, and 30 mL/kg groups, respectively. These data show that in healthy, nonbleeding subjects, crystalloid infusion may cause significant changes in hematocrit. Calculations reveal that approximately 60% of infused saline, when delivered as a bolus, will diffuse from the intravascular space within 20 minutes of administration.
Assuntos
Volume Sanguíneo , Hematócrito , Substitutos do Plasma/farmacologia , Adulto , Soluções Cristaloides , Feminino , Hemorragia/terapia , Humanos , Infusões Intravenosas , Soluções Isotônicas , Masculino , Substitutos do Plasma/administração & dosagem , Fatores de TempoAssuntos
Computadores , Glaucoma/diagnóstico , Sistemas de Informação , Projetos de Pesquisa , HumanosRESUMO
The MISAR data base system was modified for ophthalmic use. Approximately 1,165 subject records from the Glaucoma Center of Washington University were entered into this computerized registry. The system has provided a compact, accurate, and well-organized storage of medical data. Searches of the registry for specific diagnoses or for subjects who meet specific criteria have aided the performance of clinical research.
