"Ranaviruses: an emerging threat to ectothermic vertebrates" report of the First International Symposium on Ranaviruses, Minneapolis MN July 8, 2011.

This is a report of the First International Symposium on Ranaviruses held on July 8, 2011 in conjunction with the annual Joint Meeting of Ichthyologists and Herpetologists (JMIH) in Minneapolis, Minnesota, USA. The emerging threat of ranavirus infectious diseases to the global biodiversity of ectothermic vertebrates was addressed by 23 scientists from nine countries with expertise in ecology, pathology, virology, veterinary medicine and immunology.

Comparative genomic analyses of frog virus 3, type species of the genus Ranavirus (family Iridoviridae).

Frog virus 3 (FV3) is the type species member of the genus Ranavirus (family Iridoviridae). To better understand the molecular mechanisms involved in the replication of FV3, including transcription of its highly methylated DNA genome, we have determined the complete nucleotide sequence of the FV3 genome. The FV3 genome is 105903 bp long excluding the terminal redundancy. The G + C content of FV3 genome is 55% and it encodes 98 nonoverlapping potential open reading frames (ORFs) containing 50-1293 amino acids. Eighty-four ORFs have significant homology to known proteins of other iridoviruses, whereas twelve of these unique FV3 proteins do not share homology to any known protein. A microsatellite containing a stretch of 34 tandemly repeated CA dinucleotide in a noncoding region was detected. To date, no such sequence has been reported in any animal virus.