[Role of selective decontamination in combined treatment of chronic anal fissure].

Effectiveness of selective decontamination in combined treatment of patients with chronic anal fissure and concomitant proctitis was studied in clinical randomized investigation including 103 patients. The etiologically significant flora colonizing the chronic defect of the anoderma does not coincide with the composition of feces microflora and is presented by anaerobic microorganisms or a combination of aerobes and anaerobes. It was established that topical etiotropic antibacterial therapy in combination with medicamentous sphincterotomy in the outpatient treatment resulted in quicker arrest of the pain syndrome, accelerated epithelization of the fissure and made the period of treatment 2 times shorter as compared with control.

[Effects of short-term immunosuppression on the engraftment of skin transplants at syndrome of the diabetic foot].

Effects of a single administration of small doses of 5-fluorouracil on results of skin plasty for syndrome of the diabetic foot were studied in 61 patients who had undergone local operations for pyo-necrotic diseases of the foot against the background of diabetes mellitus. The completion phase of their treatment was free dermal plasty with a split skin graft. Administration of 5-fluorouracil during the plasty operation was found to be accompanied by less marked inflammatory reaction in the transplant bed and in the graft. The frequency and square surface of lysis in the transplanted dermal skin graft were considerably lowered.

[Method for improving results of local operations for pyo-necrotic disease of the foot associated with diabetes mellitus]. / Sposob uluchsheniia rezul'tatov lokal'nykh operatsii po povodu gnoino-nekroticheskikh zabolevanii stopy pri sakharnom diabete.

Under study was the influence of antimetabolite 5-fluoracil with the preferential influence on the lymphocytic link upon the outcomes of local operations in patients with diabetic foot syndrome. The investigation was performed in 95 diabetes mellitus patients who had undergone local operations for pyo-necrotic diseases of the foot. The group of investigation included 55 patients additionally given 5-fluoracil (5 mg/kg) during local operation. The injection of the drug was followed by moderate lympho- and thrombopenia arrested by the 7th day after a single injection, reduced content of the acute phase reactants and a dramatic drop of the content of circulating immune complexes. Clinically it was followed by a rapid disappearance of the inflammation signs in the wound. In the group of patients given 5-fluoracil there were reliably less reamputations, greater number of wounds healing by primary intention after the first local operation and of those successfully closed with the help of plastic operations. No general toxic effects of the used doses of the drug were noted.