[Health risk assessment of traffic-related air pollution near busy roads]. / Exposition à la pollution atmosphérique de proximité liée au trafic : quelles méthodes pour quels risques sanitaires ?

BACKGROUND: Although ambient urban air pollution has well-established health effects, epidemiology faces many difficulties in estimating the risks due to exposure to traffic pollutants near busy roads. This review aims to summarize how exposure to traffic-related air pollution near busy roads is assessed in epidemiological studies and main findings regarding health effects. METHOD: After presenting the specificity of emissions due to traffic road, this review identifies the key methods and main results found in epidemiologic studies seeking to measure the influence of exposure to nearby traffic on health published over the past decade. RESULTS: The characterization and measurement of population exposure to traffic pollution faces many difficulties. Thus, epidemiological studies have used two broad categories of surrogates to assess exposure: direct measures of traffic itself such as distance of the residence to the nearest road and traffic volume and modeled concentrations of pollutant surrogates. Studies that implemented these methods showed that people living near heavy traffic road or exposed to near-road air pollution tend to report more health outcomes. DISCUSSION: Traffic-related air pollution near busy roads is the subject of increasing attention, and tends to be better characterized. However, its health impacts remain difficult to grasp, especially because of the vast diversity of approaches used in epidemiological studies. Greater consistency in the protocols would be desirable to provide better understanding of the health issue of traffic in urban areas and thus to better implement policies to protect those most at risk.

[Measure of premature mortality: comparison of deaths before age 65 and expected years of life lost]. / La mesure de la mortalité prématurée: comparaison des décès avant 65 ans et des années espérées de vie perdues.

BACKGROUND: For many years in France, premature mortality (i.e., deaths before 65 years old) and avoidable deaths have generally been used to monitor health of the population and help to elaborate policies in this area. This paper aims to examine the utility of another indicator of premature mortality, which makes it possible to take into account the impact of deaths, the expected years of life lost (EYLL). METHODS: Mortality data for France in the years 2000 to 2002 were obtained from the Centre for Epidemiology of the Medical Causes of Death. Premature mortality was defined as death before 65 years of age. For the calculation of EYLL, the mortality norm chosen was French-life expectancy for the years 2001 to 2003. In order to study the spatial distribution of the indicators above defined, standardized ratios were calculated for each administrative area, taking France as the reference population. RESULTS: Irrespective of the gender and indicator considered, ranking of the causes emphasized three major groups of pathological conditions, which are strongly distinguished from the others: cardiovascular diseases, malignant neoplasm and injuries. The ranking of causes varied considerably according to the indicator used. The spatial representation of standardized ratios of expected years of life lost and deaths before 65 showed a strong North-South trend. CONCLUSION: The concept of premature mortality is difficult to define and discussions persist on the age limit to use for its quantification. The choice of an indicator strongly depends on the use which one wishes to make. The simple analysis of deaths before 65 years currently used to describe premature mortality in France makes it possible to describe its frequency. The use of a summary measure as EYLL allows to quantify the impact of premature mortality by giving different weights to deaths depending on the age of occurrence. EYLL, thus, seems to be an indicator, which is particularly adapted to decision-making in public health, depending on choices and values one wishes to give preference to.

[Determinants of condom use and heterosexual multiple sexual partnership in French Antilles and French Guiana]. / Déterminants de l'utilisation du préservatif et multipartenariat hétérosexuel aux Antilles et en Guyane françaises.

BACKGROUND: After Subsaharan Africa, the Caribbean is the world's region most affected by HIV/AIDS. The French-American departments (Guadeloupe, Martinique, Guiana), FAD, are located in the heart of this region. Although lower than in other states of the Caribbean, AIDS incidence is much more higher than in France (up to 15 times more in Guiana). Transmission is mostly heterosexual. The frequency, particularly among men, of multiple sexual partnerships frequently taking place concurrently, and the persistence of this activity in older age, contribute to the level of the HIV epidemic and its characteristics. The purpose of this article is to identify, in the FAD, the determinants of condom use among persons with multiple sexual partners (either at last intercourse or during a concurrent relationship), taking into account the variety of multiple sexual partnership situations. METHOD: Data are taken from an HIV/AIDS KABP survey, based on a probability sample of men and women aged 18 to 69 years, resident in FAD. In total, 3104 interviews were conducted by telephone in 2004: around 1000 in each department. RESULTS: Among men and women who report two or more partners in the past five years, there is substantial heterogeneity in level of condom use at last intercourse, depending on the duration and type of the relationship: 73% of respondents reported condom use with a casual partner and 14% with a cohabiting partner. Men and women who were engaged in concurrent partnerships in the past five years were at higher risk of infection: 7% reported an STI versus 4% among those who had two or more partners, but not at the same time. Women, older persons, people with a lower level of education and those engaged in concurrent partnerships reported a lower level of condom use, thus increasing their vulnerability to HIV/AIDS. CONCLUSION: Although HIV/AIDS prevention has increased among male and women engaged in multiple sexual partnerships, there is still a lack of consistent condom use in this population. These results highlight the need for more diversified prevention programs, taking into account sociodemographic factors and the diversity of situations involving multiple sexual partnership.

[Contribution of case-crossover design to the analysis of short-term health effects of air pollution: reanalysis of air pollution and health data]. / Apport de la méthode cas-croisé à l'analyse des effets sanitaires à court terme de la pollution atmosphérique: réanalyse de données du programme Erpurs.

BACKGROUND: During the last decades, numerous studies have shown significant links between short-term exposure to air pollution and health. Time series design have been widely used in order to study these associations. In recent years, the case-crossover design has been applied to the analysis of acute effects of environmental exposures, especially air pollution. The aims of this paper are to describe the case-crossover design and to compare this approach with time series design to assess the association between air pollution and health. METHODS: In the case-crossover approach, a case-control study is conducted whereby each person who had a health event (case period) is matched with himself/herself on a nearby time period where he/she did not have the event (control period). Review of the literature shows that the referent selection strategies can be associated to a bias in the estimation of the health effect of air pollution. In comparison with time series design, the case-crossover design is easier to conduct, and individual factors can be taken into account. Nevertheless, it is not possible to take into account the overdispersion in the health indicator with this approach. RESULTS AND CONCLUSION: In conclusion, we suggest to use time series analysis with population data and case-crossover design with individual data.

[Disability-adjusted life years: an instrument for defining public health priorities?]. / Les "Années de vie ajustées sur l'incapacité": un outil d'aide à la définition des priorités de santé publique?

BACKGROUND: The objective of this paper is the study of a health indicator allowing surveillance and evaluation of the overall health of the Paris population, and providing information to help prioritize possible choices among preventive and curative actions. Moreover, comparison between results obtained for Paris with a global health indicator, "Disability-adjusted life years" (DALYs) and available bibliographical data will enable clarifying some points about summary measures of health. METHODS: The method used is that of the Global Burden of Disease. It allows a ranking of diseases using an indicator called DALYs. This indicator integrates mortality and morbidity components by summing expected years of life lost due to premature mortality and calculated years of healthy life lost. DALYs were calculated using local mortality data and published regional disabilities tables from the World Health Organisation (WHO). RESULTS: There were a total of 242 061 DALYs for Paris for the year 1999. The six leading specific causes are: alcoholic psychosis and dependence (accounting for 6.5% of the total), lung cancers (5.7%), ischaemic hearth disease (4.8%), depression (4.4%), dementias (4.2%), and arthritis (3.9%). Men contributed the majority of DALYs for the first three. For four of the six leading causes, the majority of DALYs came from years lived with disability, rather than mortality. Only for lung cancer and ischaemic hearth disease was the majority of DALYs from years of life lost by mortality. CONCLUSION: The results for Paris are used to illustrate how DALYs can illuminate debates about public health priorities. Such data can inform the population about health condition and provide decision makers with global health indicators. The next step will be to estimate the DALYs from local morbidity data when available, and compare these results to those based on the World Health Organisation tables, which are not sensitive to local results other than those due to mortality. Future steps include further evaluation and development of this method for surveillance, assessment and evaluation of public health actions. However, some of the results obtained with this indicator underline the limits of this kind of analysis.

[What are the epidemiological data concerning parental smoking and breastfeeding?]. / Quelles sont les données épidémiologiques concernant le tabagisme parental et l'allaitement maternel?

Exclusive breastfeeding for 6 months provides important protection against respiratory infections in the newborn's first year of life. But smoking by either parent not only creates excess risk of respiratory illness for the baby, it also plays an important role both in not breastfeeding or in early weaning, thus depriving the infant of the potential protections of receiving mother's milk. Considering this information, three main recommendations can be made: promoting smoking cessation by the mother and also by the father may be a key to successful efforts to encourage breastfeeding; a smoking mother can enhance her chances of successful breastfeeding by avoiding smoking at least 2(1/2) hours prior to each feeding; a smoking father can enhance breastfeeding by avoiding exposing the mother as much as he should avoid exposing the infant to tobacco smoke.

[Adaptive behaviors to HIV risk of transmission in different populations]. / Les comportements d'adaptation aux risques de transmission du VIH dans différentes populations.

Since the beginning of the HIV epidemic in France, surveys aimed at better understanding risk perceptions of HIV infection and preventive sexual behaviors have been implemented in the general population, and in populations such as IVDU and homosexual men, more concerned by risks of HIV transmission. The objective of this article is to describe these surveys, to present their main results and to assess what has been the overall impact of prevention campaigns on the adoption of preventive sexual behaviors in these populations. The results show that very early after the beginning of the AIDS epidemic, both general and homosexual populations have adopted preventive sexual behaviors, mainly increasing condom use and implementing other preventive strategies. However, with the introduction of HAART in 1996, a slackening of these preventive behaviors is noted. The use of condom is less frequent, especially in the youngest generations of both general and homosexual populations. On the opposite, among IVDU, the use of sterile syringes increased dramatically as soon as over-the-counter sales of syringes was authorized in 1987, as well as the adoption of ways other than intravenous to take drugs. Both have contributed to almost stop the HIV epidemic in this specific group. The results of these surveys show that the benefits of prevention campaigns are different between populations and are reversible. It is necessary to renew the messages, campaigns and programs of prevention with the renewal of generations. It is also necessary to adapt these messages to the new scientific data, and to the evolution of social and individual representations of the disease.

Air pollution and respiratory hospital admissions in greater Paris: exploring sex differences.

The subject of sex and gender differences is relevant to the study of health effects of environmental exposures. In this study the authors aim at assessing the differences that may exist between males and females regarding short-term air pollution health effects. They studied the short-term relationships between air pollution levels and respiratory hospital admissions in greater Paris area for patients older than 15 years between 2000 and 2003. They also conducted time series analyses by using generalized additive models. For an increase of 10 microg/m3 in the air pollutant levels, the increase in relative risk of hospitalization was higher for males than for females and was significant only for males. These differences may not result solely from differences in biological susceptibility to air pollution because other factors related to gender (differences in individual exposures, in health care management, and so on) may play a role.

AIDS and contraception. Unanticipated effects of AIDS prevention campaigns.

BACKGROUND: This study addresses the effects of AIDS prevention campaigns on contraceptive practices among the general population in France. Comparisons of contraceptive practices and condom use by women aged 18-49 years were performed in two national population-based surveys (n = 559 in 1994, n = 731 in 1998). RESULTS: A decrease in the proportion of women aged 20-24 with multiple partners reporting the use of contraception was observed between 1994 and 1998. In the same time, there was an increase in the use of condoms to prevent AIDS. CONCLUSION: Findings suggest that single-risk prevention campaigns on AIDS may lead some women to pay less attention to the risk of unwanted pregnancy.

A one-year prospective study (1994-1995) for a first evaluation of tuberculosis transmission in French prisons.

SETTING: Ten correctional facilities in Paris, including suburbs. OBJECTIVE: To prospectively determine the incidence of tuberculosis (TB) in prisons during a one-year period and to trace the transmission of tuberculosis by restriction fragment length polymorphism (RFLP) analysis of Mycobacterium tuberculosis strains from inmates. RESULTS: Of 93 cases of tuberculosis observed, 50 were culture-confirmed. The incidence of tuberculosis in correctional facilities was 215 cases per 100,000 inmates. A high turnover of inmates was observed. All patients were male, and a quarter had been homeless. Seventy-two per cent were diagnosed with pulmonary tuberculosis. Several severe cases of TB were observed, including three of tuberculous meningitis. No multidrug-resistant strains were noted. RFLP analysis (n = 24) revealed 22 distinct patterns which made up two clusters. Epidemiological investigation did not show direct tuberculosis transmission, which was, however, probable for one cluster. CONCLUSION: Independently of incarceration, prison inmates run a higher risk of developing active tuberculosis than the general population, which might be the main reason for the high incidence of tuberculosis observed in prisons. However, some cases of transmission may occur inside prisons.

[Do adolescents of the Parisian suburbs take more drugs than others?]. / Existe-t-il une surconsommation de drogue parmi les jeunes de la région parisienne?

BACKGROUND: Because official statistics (e.g. mortality and morbidity data) report the high prevalence of drug abusers in the Parisian region, we hypothesized that drug use is higher in Parisian suburbs than in other regions of France. METHODS: Two epidemiological surveys were carried out in 1993: one among 12,391 adolescents in secondary schools aged 11 to 19, another among 2,821 youth, aged 16 to 24, in the scholar rehabilitation system. The level of drug use (alcohol, tobacco, cannabis and other illicit drugs) and associated behavior (violent behavior, school absenteeism, suicide attempt and road accidents) was compared between youth living in the Ile-de-France region (IDF) and youth living outside the region (NIDF). RESULTS: 1/Alcohol and tobacco consumption rates were lower in the IDF than in the NIDF; 2/There was no statistical difference between the illicit drug consumption rates in IDF and NIDF; 3/The association between alcohol, tobacco and cannabis was more frequent in IDF than in NIDF; 4/There was an association between drug use and the other behavioral problems among French youth, independent of the region. CONCLUSION: In 1993, there was no difference between Parisian region and the outside of the region, as far as drug consumption is concerned. One can expect, in the future, a more homogeneous pattern of mortality and morbidity statistics between regions.

Low birthweight at term and the timing of fetal exposure to maternal smoking.

OBJECTIVES: This study was undertaken to evaluate the risk of small-for-gestational-age birth for women who stop smoking or begin to smoke during pregnancy. METHODS: Women with term singleton pregnancies from a hospital-based cohort of 11,177 were classified as (1) nonsmokers; (2) smoked throughout pregnancy; (3) smoked during first trimester only; (4) smoked during first and second trimesters only; and (5) smoked during second and third trimesters or during third trimester only. Risk of small-for-gestational-age birth according to smoking category was estimated and adjusted for confounding factors by logistic regression. RESULTS: Women who stopped smoking by the third trimester were not at increased risk of small-for-gestational-age birth compared with nonsmokers. Women who began smoking during the second or third trimester had an elevated risk of small-for-gestational-age birth (odds ratio [OR] = 1.83; 95% confidence interval [CI] = 1.25, 2.67) similar to that for women who smoked throughout pregnancy (OR = 2.20; 95% CI = 1.90, 2.54). Risk of small-for-gestational-age birth increased with the number of cigarettes smoked during the third trimester. CONCLUSIONS: It is during the third trimester that smoking retards fetal growth, presenting a compelling opportunity for smoking cessation interventions. Programs must emphasize the importance of not resuming smoking late in pregnancy.

Mothers of sexually abused children: trauma and repair in longitudinal perspective.

Mothers whose children had been sexually abused reported experiencing serious psychological symptoms following disclosure of the abuse. Over a one-year period, their emotional status improved. Strong relationships between mothers' reports of their own and their children's symptoms were accompanied by persistent discrepancies between maternal and direct assessments of the children's emotional states. Findings suggest that addressing maternal distress is important to the study and treatment of child sexual abuse.