RESUMO
BACKGROUND AND OBJECTIVES: Autoantibodies to CD36, a platelet glycoprotein, have been found in patients with thrombotic thrombocytopenic purpura, and in those with lupus-like anticoagulant with thrombotic complications. MATERIALS AND METHODS: Conventional hematologic and laboratory methods were used. The patient was a pregnant woman, who had had two early fetal losses separated by a normal offspring. Despite severe thrombocytopenia, she was asymptomatic. RESULTS: Serological investigations were strongly suggestive of CD36 autoantibodies. Neither clinical nor laboratory data were typical of those usually associated with cd36 autoantibodies, namely thrombotic thrombocytopenic purpura (TTP), systemic lupus erythematosis (SLE), or prothrombotic compliance. Prophylaxis with salicylates and prednisone was started at the 8th week of gestation, and an offspring with mild thrombocytopenia was delivered by cesarean section at the 32nd week of gestation because of abruptio placentae. CONCLUSIONS: There may be a cause-and-effect relationship between early fetal losses and CD36 autoantibodies.
Assuntos
Aborto Habitual/imunologia , Autoanticorpos/sangue , Antígenos CD36/imunologia , Púrpura Trombocitopênica Trombótica/imunologia , Trombose/imunologia , Adulto , Suscetibilidade a Doenças/imunologia , Feminino , Humanos , Inibidor de Coagulação do Lúpus/imunologia , GravidezRESUMO
Agenesis of the corpus callosum is a central nervous system anomaly that may be associated with other intracranial abnormalities. It is easily diagnosed in the postnatal period by computed tomographic scan and ultrasound. However, its prenatal sonographic diagnosis remains a challenge. This report will evaluate three cases of fetal agenesis of the corpus callosum, review the antenatal sonographic findings and postnatal outcomes, and provide criteria for the antenatal diagnosis.
Assuntos
Agenesia do Corpo Caloso , Diagnóstico Pré-Natal , Ultrassonografia , Adulto , Desenvolvimento Infantil , Corpo Caloso/diagnóstico por imagem , Eletroencefalografia , Feminino , Humanos , Testes Neuropsicológicos , Gravidez , Tomografia Computadorizada por Raios XRESUMO
The Authors review their series of pre- and post-operatory urethrocystographies in SUI and discuss their data according to the interpretative criteria proposed by the leading authors. None of the suggested criteria seems satisfactory at all; however, cystography seems undoubtedly useful in the overall comprehension of SUI pathogenesis; moreover, when it is supported with a complete urodynamic evaluation, it can lead to the most exact diagnosis and permit the most proper therapeutical approach.