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Radiats Biol Radioecol ; 39(2-3): 354-7, 1999.
Artigo em Russo | MEDLINE | ID: mdl-10366970

RESUMO

Radiation activation of angiotensin-converting enzyme (respect to Cbz-Phe-His-Leu as substrate) was obtained at the gamma (137Cs, t(irr) = 10s-2h, D approximately 3 Gy)- and X (plasma foces source, t(irr) = 10(-9)s, Cu-filter, D approximately 2 x 10(-5) Gy)-irradiation. The inactivation of the horseradish peroxidase at the same X-irradiation dose (2 x 10(-5) Gy) took place. Based on the experimental data and on the mathematical model proposed by us we made a conclusion that the special points exist on the dose response curves. Besides, the deduction that an activation is a common process at radiation changes of the different enzymes follows from our model. The activation of tobacco peroxidase (in presence of Ca(2+)-cations and without them) and of recombinant horseradish peroxidase (in presence of H2O2) by gamma-irradiation was really observed (respect to guaiacol as substrate).


Assuntos
Peptidil Dipeptidase A/metabolismo , Animais , Bovinos , Ativação Enzimática , Raios gama , Peroxidase do Rábano Silvestre/metabolismo , Concentração de Íons de Hidrogênio , Técnicas In Vitro , Peptidil Dipeptidase A/efeitos da radiação , Doses de Radiação , Especificidade por Substrato
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