Reference Data for Diagnosis of Spondylolisthesis and Disc Space Narrowing Based on NHANES-II X-rays.

Robust reference data, representing a large and diverse population, are needed to objectively classify measurements of spondylolisthesis and disc space narrowing as normal or abnormal. The reference data should be open access to drive standardization across technology developers. The large collection of radiographs from the 2nd National Health and Nutrition Examination Survey was used to establish reference data. A pipeline of neural networks and coded logic was used to place landmarks on the corners of all vertebrae, and these landmarks were used to calculate multiple disc space metrics. Descriptive statistics for nine SPO and disc metrics were tabulated and used to identify normal discs, and data for only the normal discs were used to arrive at reference data. A spondylolisthesis index was developed that accounts for important variables. These reference data facilitate simplified and standardized reporting of multiple intervertebral disc metrics.

Definition of Normal Vertebral Morphometry Using NHANES-II Radiographs.

A robust definition of normal vertebral morphometry is required to confidently identify abnormalities such as fractures. The Second National Health and Nutrition Examination Survey (NHANES-II) collected a nationwide probability sample to document the health status of the United States. Over 10,000 lateral cervical spine and 7,000 lateral lumbar spine X-rays were collected. Demographic, anthropometric, health, and medical history data were also collected. The coordinates of the vertebral body corners were obtained for each lumbar and cervical vertebra using previously validated, automated technology consisting of a pipeline of neural networks and coded logic. These landmarks were used to calculate six vertebral body morphometry metrics. Descriptive statistics were generated and used to identify and trim outliers from the data. Descriptive statistics were tabulated using the trimmed data for use in quantifying deviation from average for each metric. The dependency of these metrics on sex, age, race, nation of origin, height, weight, and body mass index (BMI) was also assessed. There was low variation in vertebral morphometry after accounting for vertebrae (eg, L1, L2), and the R 2 was high for ANOVAs. Excluding outliers, age, sex, race, nation of origin, height, weight, and BMI were statistically significant for most of the variables, though the F-statistic was very small compared to that for vertebral level. Excluding all variables except vertebra changed the ANOVA R 2 very little. Reference data were generated that could be used to produce standardized metrics in units of SD from mean. This allows for easy identification of abnormalities resulting from vertebral fractures, atypical vertebral body morphometries, and other congenital or degenerative conditions. Standardized metrics also remove the effect of vertebral level, facilitating easy interpretation and enabling data for all vertebrae to be pooled in research studies. © 2022 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.

Analysis of translation and angular motion in loaded and unloaded positions in the lumbar spine.

BACKGROUND CONTEXT: Abnormalities in intervertebral rotation and translation are important to diagnosis and treatment planning for common spinal disorders. Tests that do not sufficiently load the spine can result in mis-diagnosed motion abnormalities. Upright flexion and extension x-rays are commonly used despite known limitations. Additional evidence is needed in support of preliminary studies suggesting that the change from standing to supine may sufficiently stress the spine to diagnose motion abnormalities. PURPOSE: Compare intervertebral translation between flexion and extension to translation between upright and supine positions in a representative clinical population. STUDY DESIGN/SETTING: Prospective analysis of images retrospectively collected from routine clinical practices. METHODS: After obtaining IRB approval for analysis of previously obtained images, patients were identified via chart reviews where a neutral-lateral x-ray and an MRI or CT exam were obtained for diagnosis of a spinal disorder and where flexion-extension x-rays had been obtained to help diagnose abnormal intervertebral motion. The mid-sagittal slice from the MRI or CT exam was paired with the neutral-lateral radiograph. Intervertebral translation at the L4-L5 and L5-S1 levels between supine and standing and between flexion and extension were measured from the images using previously validated methods. The translations were classified as normal or abnormal with reference to a previously obtained database of intervertebral motion in radiographically normal and asymptomatic volunteers. RESULTS: At the L5-S1 level in particular, there tended to be greater translation between the supine and standing than between upright flexion and extension. On average, translations were below that found in asymptomatic volunteers. No abnormal translations were detected from flexion-extension radiographs whereas approximately 7% of levels had abnormal translations between supine and upright positions. CONCLUSIONS: Intervertebral translations between supine and standing, measured using the mid-sagittal slice from a MRI or CT exam and a lateral x-ray with the patient standing can help to identify abnormal motion. This would be particularly valuable for patients with limited flexion and extension. This study thereby adds to the evidence in support of measuring intervertebral motion between the supine and upright positions to detect abnormal intervertebral motion.

In Vivo Kinematic Comparison of a Bicruciate Stabilized Total Knee Arthroplasty and the Normal Knee Using Fluoroscopy.

BACKGROUND: The bicruciate stabilized (BCS) total knee arthroplasty (TKA) features asymmetrical bearing geometry and dual substitution for the anterior cruciate ligament and posterior cruciate ligament (PCL). Previous TKA designs have not fully replicated normal knee motion, and they are characterized by lower magnitudes of overall rollback and axial rotation than the normal knee. METHODS: In vivo kinematics were derived for 10 normal knees and 40-second generation BCS TKAs all implanted by a single surgeon. Mobile fluoroscopy and three-dimensional-to-two-dimensional registration was used to analyze anterior-posterior motion of the femoral condyles and femorotibial axial rotation during weight-bearing flexion. Statistical analysis was conducted at the 95% confidence level. RESULTS: From 0° to 30° of knee flexion, the BCS subjects exhibited similar patterns of femoral rollback and axial rotation compared to normal knee subjects. From 30° to 60° of knee flexion, BCS subjects experienced negligible anterior-posterior motions and axial rotation while normal knees continued to rollback and externally rotate. Between 60° and 90° the BCS resumed posterior motion and, after 90°, axial rotation increased in a normal-like fashion. CONCLUSION: Similarities in early flexion kinematics suggest that the anterior cam-post is supporting normal-like anterior-posterior motion in the BCS subjects. Likewise, lateral femoral rollback and external rotation of the femur in later flexion provides evidence for appropriate substitution of the PCL via the posterior cam-post. Being discrete in nature, the dual cam-post mechanism does not lend itself to adequate substitution of the cruciate ligaments in mid-flexion during which anterior cruciate ligament tension is decreasing and PCL tension is increasing in the normal knee.

In Vivo Three-Dimensional Patellar Mechanics: Normal Knees Compared with Domed and Anatomic Patellar Components.

BACKGROUND: Patellofemoral complications are a major cause of revision surgery following total knee arthroplasty (TKA). High forces occurring at the patellofemoral articulation coupled with a small patellofemoral contact area pose substantial design challenges. In this study, the three-dimensional (3D) in vivo mechanics of domed and anatomically shaped patellar components were compared with those of native patellae. METHODS: Ten normal knees, 10 treated with an LCS-PS (low contact stress-posterior stabilized) TKA (anatomically shaped patellar component), and 10 treated with a PFC Sigma RP-PS (press-fit condylar Sigma rotating platform-posterior stabilized) TKA (domed patellar component) were analyzed under fluoroscopic surveillance while the patient performed a weight-bearing deep knee bend from full knee extension to maximum knee flexion. Relevant bone geometries were segmented out from computed tomography (CT) scans, and computer-assisted-design (CAD) models of the implanted components were obtained from the manufacturer. Three-dimensional patellofemoral kinematics were obtained using a 3D-to-2D registration process. Contact mechanics were calculated using a distance map between the articulating patellar and femoral surfaces. RESULTS: Both patellar component designs exhibited good rotational kinematics and tracked well within the femoral trochlea when compared with the normal patella. The contact areas in the TKA groups peaked at 60° of knee flexion (mean and standard deviation, 201 ± 63.4 mm for the LCS-PS group and 218 ± 95.4 mm for the Sigma RP-PS group), and the areas were substantially smaller than those previously reported for the normal patella. Contact points in the TKA groups stayed close to the center of the patellar components. CONCLUSIONS: Both designs performed satisfactorily, although patellofemoral contact areas were reduced in comparison with those in the native patella. LEVEL OF EVIDENCE: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.

Single Versus Multiple-Radii Cruciate-Retaining Total Knee Arthroplasty: An In Vivo Mobile Fluoroscopy Study.

BACKGROUND: Previous fluoroscopic studies, using static C-arm systems, have shown nonnormal kinematic patterns in cruciate-retaining (CR) total knee arthroplasty (TKA). This study compares in vivo the kinematic differences in subjects implanted with single sagittal radius (SR) vs multiradii (MR) CR TKA for various activities using a novel mobile fluoroscopic system. METHODS: Using mobile fluoroscopy and 3D to 2D registration, tibiofemoral kinematics were analyzed for 25 subjects with an SR, symmetrical condylar CR TKA and 25 subjects with an MR, asymmetric condylar CR TKA for three dynamic weight-bearing activities: (1) deep knee bend (DKB), (2) walking up a ramp, and (3) walking down a ramp. RESULTS: During DKB, from full extension to maximum knee flexion, the SR (-0.43 ± 3.43 mm) and MR (-1.00 ± 3.23 mm) groups experienced statistically similar anterior/posterior (AP) motion in the lateral condyle. The SR (3.51 ± 2.68 mm) group had significant anterior movement compared to the MR (-0.42 ± 2.20 mm) group in the medial condyle. This resulted in a significantly larger amount of normal axial rotation experienced by the SR (5.20 ± 3.93°) group compared to the MR (0.75 ± 5.12°) group. During ramp activities, the SR TKA consistently exhibited a significantly more posterior position of both condyles compared to the MR TKA. CONCLUSION: Although the SR TKA exhibited larger amounts of axial rotation compared to the MR TKA in DKB, neither design exhibited weight-bearing kinematics as previously reported for the normal knee. Additional research on the normal knee for ramp activities is required to understand the importance of condylar position during these activities.