1.
J Pediatr Hematol Oncol
; 26(6): 386-8, 2004 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15167354
RESUMO
Methotrexate (MTX) is an antifolate that affects many metabolic pathways. MTX may cause neurologic toxicity, but the biochemical effects of MTX on the central nervous system (CNS) are poorly characterized. The authors studied serial cerebrospinal fluid (CSF) samples from a child during two courses of intraventricular MTX and found a rapid and reproducible depletion in CSF of reduced folates and S-adenosylmethionine that was accompanied by marked increases in homocysteine and adenosine. No sulfur-containing excitatory amino acids were detected. This study demonstrates multiple profound effects of MTX on CNS metabolism and provides insight to the pathogenesis of MTX neurotoxicity.
Assuntos
Aminoácidos/líquido cefalorraquidiano , Antimetabólitos Antineoplásicos/uso terapêutico , Linfoma de Burkitt/tratamento farmacológico , Epinefrina/líquido cefalorraquidiano , Ácido Fólico/líquido cefalorraquidiano , Homocisteína/líquido cefalorraquidiano , Metotrexato/uso terapêutico , Antimetabólitos Antineoplásicos/administração & dosagem , Linfoma de Burkitt/líquido cefalorraquidiano , Linfoma de Burkitt/patologia , Pré-Escolar , Humanos , Injeções Intraventriculares , Masculino , Metotrexato/administração & dosagem , Estadiamento de Neoplasias
2.
Am J Health Syst Pharm
; 60(7): 687-90, 2003 Apr 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12701551